Search Results - "Lee, David K"

CRAFT-A Proposed Framework for Decentralized Clinical Trials Participation in Canada by Sundquist, Stephen, Batist, Gerald, Brodeur-Robb, Kathy, Dyck, Kathryn, Eigl, Bernhard J, Lee, David K, Limoges, Jaqueline, Longstaff, Holly, Pankovich, Jim, Sadura, Anna, Sullivan, Patrick, Dancey, Janet E

“…Canada's vast geography, and centralized delivery of cancer care and clinical trials create barriers for trial participation for patients in remote and rural…”
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Novel Coronavirus-Induced Right Ventricular Failure and Point of Care Echocardiography: A Case Report by Chen, Lu, Upadhya, Gautham, Guo, Uta S, Belligund, Pooja, Lee, David K, Shalom, Isaac, Dubey, Gangacharan R, Al-Ajam, Mohammad R, Mitre, Cristina A

“…Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury,…”
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The Novel Angiotensin-Converting Enzyme (ACE) Homolog, ACE2, Is Selectively Expressed by Adult Leydig Cells of the Testis by Douglas, Gabrielle C, O’Bryan, Moira K, Hedger, Mark P, Lee, David K. L, Yarski, Michael A, Smith, A. Ian, Lew, Rebecca A

“…The metallopeptidase angiotensin-converting enzyme (ACE) plays a pivotal role in the cardiovascular system by generating the vasoconstrictor peptide…”
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Discovery of N-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain by Annedi, Subhash C, Maddaford, Shawn P, Mladenova, Gabriela, Ramnauth, Jailall, Rakhit, Suman, Andrews, John S, Lee, David K. H, Zhang, Dongqin, Porreca, Frank, Bunton, David, Christie, Lee

“…3,6-Disubstituted indole derivatives were designed, synthesized, and evaluated as inhibitors of human nitric oxide synthase (NOS). Bulky amine containing…”
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1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: Lead Optimization Studies Resulting in the Identification of N-(1-(2-(Methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a Preclinical Development Candidate by Ramnauth, Jailall, Renton, Paul, Dove, Peter, Annedi, Subhash C, Speed, Joanne, Silverman, Sarah, Mladenova, Gabriela, Maddaford, Shawn P, Zinghini, Salvatore, Rakhit, Suman, Andrews, John, Lee, David K. H, Zhang, Dongqin, Porreca, Frank

“…Numerous studies have shown that selective nNOS inhibitors could be therapeutic in many neurological disorders. Previously, we reported a series of…”
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In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2) by Labrie, Philippe, Maddaford, Shawn P., Lacroix, Jacques, Catalano, Concettina, Lee, David K.H., Rakhit, Suman, Gaudreault, René C.

“…Synthesis and in vitro cytotoxicity assays of new anthranilamide MDR modulators have been performed to assess their potency of inhibition of P-glycoprotein…”
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In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450 by Labrie, Philippe, Maddaford, Shawn. P., Lacroix, Jacques, Catalano, Concettina, Lee, David K.H., Rakhit, Suman, Gaudreault, René C.

“…Synthesis and in vitro cytotoxicity assays of new anthranilamide MDR modulators were performed to assess their potency to inhibit P-glycoprotein and CYP450…”
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The role of synaptotagmin I C2A calcium-binding domain in synaptic vesicle clustering during synapse formation by Gardzinski, Peter, Lee, David W. K., Fei, Guang‐He, Hui, Kwokyin, Huang, Guan J., Sun, Hong‐Shuo, Feng, Zhong‐Ping

“…Synaptic vesicles aggregate at the presynaptic terminal during synapse formation via mechanisms that are poorly understood. Here we have investigated the role…”
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An Orphan Drug Framework (ODF) for Canada by Lee, David K, Wong, Barbara

“…An orphan drug is a pharmaceutical or biological drug that is used to treat a rare disease. The development of a Canadian orphan drug framework is intended to…”
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Recognizing that Evidence is Made, not Born by Lim, Robyn, Lee, David K., Sabourin, Pierre, Ferguson, John, Metcalf, Marilyn, Smith, Meredith, Corriol‐Rohou, Solange, Eichler, Hans‐Georg, Lumpkin, Murray, Hirsch, Gigi, Chen, Inhua Muijrers, O'Rourke, Brian, Schiel, Anja, Crabb, Nick, Aronson, Naomi, Pezalla, Edmund, Boutin, Marc, Binder, Louise, Wilhelm, Linda

“…Therapeutic product development, licensing and reimbursement may seem a well‐oiled machine, but continuing high attrition rates, regulatory refusals, and…”
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Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery by Rosenberg, Yvonne J., Adams, Robert J., Hernandez-Abanto, Segundo, Jiang, Xiaoming, Sun, Wei, Mao, Lingjun, Lee, K. David

“…Recombinant (r) and native butyrylcholinesterse (BChE) are potent bioscavengers of organophosphates (OPs) such as nerve agents and pesticides and are…”
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Pharmacogenomic testing: Enhancing personalized medication use for patients by Loucks, Catrina M, Groeneweg, Gabriella, Roy, Carl, Lee, David K, Rieder, Michael J, Lebel, Denis, Ito, Shinya, Ross, Colin J, Carleton, Bruce C

“…Pharmacogenomics, the determination of the genomic predisposition to a certain response to medication, is a key component in understanding how to use…”
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Characterization of Water in Proton-Conducting Membranes by Deuterium NMR T 1 Relaxation by Lee, David K, Saito, Tomonori, Benesi, Alan J, Hickner, Michael A, Allcock, Harry R

“…2H T 1 NMR relaxation was used to characterize the molecular motion of deuterated water (2H2O) in Aquivion E87-05, Nafion 117, and sulfonated-Radel…”
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Training on a Lower Body Positive Pressure Treadmill With Body Weight Support does not Improve Aerobic Capacity by Lee, David K, Maltz, Natalie A, Becker, James, Cotter, Joshua A

“…This study examined the physiological changes resulting from training on a lower body positive pressure treadmill (LBPPT) at three different levels of body…”
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Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors by Ramnauth, Jailall, Speed, Joanne, Maddaford, Shawn P, Dove, Peter, Annedi, Subhash C, Renton, Paul, Rakhit, Suman, Andrews, John, Silverman, Sarah, Mladenova, Gabriela, Zinghini, Salvatore, Nair, Sheela, Catalano, Concettina, Lee, David K.H, De Felice, Milena, Porreca, Frank

“…Neuronal nitric oxide synthase (nNOS) inhibitors are effective in preclinical models of many neurological disorders. In this study, two related series of…”
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Phase changes of poly(alkoxyphosphazenes), and their behavior in the presence of oligoisobutylene by Weikel, Arlin L., Lee, David K., Krogman, Nicholas R., Allcock, Harry R.

“…A series of closely related polyphosphazenes with propoxy, pentoxy, hexoxy, octoxy, isostearyloxy, and 2‐(2‐methoxyethoxy)ethoxy (MEE) side groups, together…”
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Synthesis and inclusion behavior of cyclotriphosphazene molecules with asymmetric spiro rings by Lee, David K Y, Jackson, Anne-Martine S, Fushimi, Toshiki, Yennawar, Hemant, Allcock, Harry R

“…Two novel cyclic phosphazenes with asymmetric spiro rings were synthesized via reactions of hexachlorocyclotriphosphazene with chiral amino alcohol residues…”
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Characterization of water in proton-conducting membranes by deuterium NMR T1 relaxation by Lee, David K, Saito, Tomonori, Benesi, Alan J, Hickner, Michael A, Allcock, Harry R

“…(2)H T(1) NMR relaxation was used to characterize the molecular motion of deuterated water ((2)H(2)O) in Aquivion E87-05, Nafion 117, and sulfonated-Radel…”
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Health Canada's Progressive Licensing Framework by Yeates, Neil, Lee, David K, Maher, Maurica

“…Health Canada is modernizing the regulatory process for pharmaceutical and biologic products through a project called the Progressive Licensing Framework.1…”
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2-Substituted Tryptamines:  Agents with Selectivity for 5-HT6 Serotonin Receptors by Glennon, Richard A, Lee, Mase, Rangisetty, Jagadeesh B, Dukat, Malgorzata, Roth, Bryan L, Savage, Jason E, McBride, Ace, Rauser, Laura, Hufeisen, Sandy, Lee, David K. H

“…Several 2-alkyl-5-methoxytryptamine analogues were designed and prepared as potential 5-HT6 serotonin agonists. It was found that 5-HT6 receptors accommodate…”
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