Search Results - "Lee, Cindy J"

Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets by Tang, Fanying, Xu, Duo, Wang, Shangqian, Wong, Chen Khuan, Martinez-Fundichely, Alexander, Lee, Cindy J, Cohen, Sandra, Park, Jane, Hill, Corinne E, Eng, Kenneth, Bareja, Rohan, Han, Teng, Liu, Eric Minwei, Palladino, Ann, Di, Wei, Gao, Dong, Abida, Wassim, Beg, Shaham, Puca, Loredana, Meneses, Maximiliano, de Stanchina, Elisa, Berger, Michael F, Gopalan, Anuradha, Dow, Lukas E, Mosquera, Juan Miguel, Beltran, Himisha, Sternberg, Cora N, Chi, Ping, Scher, Howard I, Sboner, Andrea, Chen, Yu, Khurana, Ekta

“…In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic…”
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d-Alanine: Distribution, origin, physiological relevance, and implications in disease by Lee, Cindy J., Qiu, Tian A., Sweedler, Jonathan V.

“…d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is…”
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Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses by Yan, Juan, Chen, Yuedan, Patel, Amish J, Warda, Sarah, Lee, Cindy J, Nixon, Briana G, Wong, Elissa Wp, Miranda-Román, Miguel A, Yang, Ning, Wang, Yi, Pachai, Mohini R, Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Jr, Phillip M, Maag, Jesper Lv, Koche, Richard P, Zheng, Deyou, Antonescu, Cristina R, Deng, Liang, Li, Ming O, Chen, Yu, Chi, Ping

“…Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert…”
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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry by Patel, Amish J, Warda, Sarah, Maag, Jesper L V, Misra, Rohan, Miranda-Román, Miguel A, Pachai, Mohini R, Lee, Cindy J, Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W P, Yan, Juan, Giff, Emily, Pappalardi, Melissa B, McCabe, Michael T, Fletcher, Jonathan A, Rudin, Charles M, Chandarlapaty, Sarat, Scandura, Joseph M, Koche, Richard P, Glass, Jacob L, Antonescu, Cristina R, Zheng, Deyou, Chen, Yu, Chi, Ping

“…Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent…”
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Physiopathological Relevance of D-Serine in the Mammalian Cochlea by Wang, Jing, Serratrice, Nicolas, Lee, Cindy J, François, Florence, Sweedler, Jonathan V, Puel, Jean-Luc, Mothet, Jean-Pierre, Ruel, Jérôme

“…NMDA receptors (NMDARs) populate the complex between inner hair cell (IHC) and spiral ganglion neurons (SGNs) in the developing and mature cochlea. However, in…”
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Relations between Glucose and d‑Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans by Lee, Cindy J., Lee, Dong-Kyu, Wei, I-An, Qiu, Tian A., Rubakhin, Stanislav S., Roper, Michael G., Sweedler, Jonathan V.

“…The cell-to-cell signaling role of d-amino acids (d-AAs) in the mammalian endocrine system, particularly in the islets of Langerhans, has drawn growing…”
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d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans by Lee, Cindy J, Schnieders, Jack H, Rubakhin, Stanislav S, Patel, Amit V, Liu, Chengyang, Naji, Ali, Sweedler, Jonathan V

“…The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide…”
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Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice by Qiu, Tian (Autumn), Lee, Cindy J., Huang, Chen, Lee, Dong-Kyu, Rubakhin, Stanislav S., Romanova, Elena V., Sweedler, Jonathan V.

“…Microbiome-derived metabolites are important for the microbiome-gut-brain axis and the discovery of new disease treatments. d -Alanine ( d -Ala) is found in…”
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Profiling of d‐alanine production by the microbial isolates of rat gut microbiota by Lee, Cindy J., Qiu, Tian A., Hong, Zhilai, Zhang, Zhenkun, Min, Yuhao, Zhang, Linzixuan, Dai, Lei, Zhao, Huimin, Si, Tong, Sweedler, Jonathan V.

“…d‐alanine (d‐Ala) and several other d‐amino acids (d‐AAs) act as hormones and neuromodulators in nervous and endocrine systems. Unlike the endogenously…”
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MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST) by Miranda-Román, Miguel A, Lee, Cindy J, Fishinevich, Eve, Ran, Leili, Patel, Amish J, Yan, Juan, Khudoynazarova, Makhzuna N, Warda, Sarah, Pachai, Mohini R, Chen, Yu, Chi, Ping

“…Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft tissue sarcoma with a high propensity to metastasize and extremely…”
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Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor by Chi, Ping, Qin, Li-Xuan, Nguyen, Bastien, Kelly, Ciara M, D'Angelo, Sandra P, Dickson, Mark A, Gounder, Mrinal M, Keohan, Mary L, Movva, Sujana, Nacev, Benjamin A, Rosenbaum, Evan, Thornton, Katherine A, Crago, Aimee M, Yoon, Sam, Ulaner, Gary, Yeh, Randy, Martindale, Moriah, Phelan, Haley T, Biniakewitz, Matthew D, Warda, Sarah, Lee, Cindy J, Berger, Michael F, Schultz, Nikolaus D, Singer, Samuel, Hwang, Sinchun, Chen, Yu, Antonescu, Cristina R, Tap, William D

“…Dual targeting of the gastrointestinal stromal tumor (GIST) lineage-specific master regulators, ETV1 and KIT, by MEK and KIT inhibitors were synergistic…”
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Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors by Chi, Ping, Qin, Li-Xuan, Camacho, Niedzica, Kelly, Ciara M, D'Angelo, Sandra P, Dickson, Mark A, Gounder, Mrinal M, Keohan, Mary L, Movva, Sujana, Nacev, Benjamin A, Rosenbaum, Evan, Thornton, Katherine A, Crago, Aimee M, Francis, Jasmine H, Martindale, Moriah, Phelan, Haley T, Biniakewitz, Matthew D, Lee, Cindy J, Singer, Samuel, Hwang, Sinchun, Berger, Michael F, Chen, Yu, Antonescu, Cristina R, Tap, William D

“…This phase Ib trial was designed to evaluate the safety and early efficacy signal of the combination of imatinib and binimetinib in patients with…”
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ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer by Li, Dan, Zhan, Yu, Wang, Naitao, Tang, Fanying, Lee, Cindy J, Bayshtok, Gabriella, Moore, Amanda R, Wong, Elissa W P, Pachai, Mohini R, Xie, Yuanyuan, Sher, Jessica, Zhao, Jimmy L, Khudoynazarova, Makhzuna, Gopalan, Anuradha, Chan, Joseph, Khurana, Ekta, Shepherd, Peter, Navone, Nora M, Chi, Ping, Chen, Yu

“…The mechanisms underlying -driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this…”
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2083-P: Dynamics of D-Amino Acids in Mammalian Pancreatic Islets by LEE, CINDY J., PATEL, AMIT, LEE, DONGKYU, RUBAKHIN, STANISLAV, SWEEDLER, JONATHAN V.

“…Evidence has shown the presence of D-amino acids (D-AAs), unusual cell-to-cell signaling molecules, in the pancreatic islets of rodents and humans. In…”
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Tumor-intrinsic PRC2 inactivation drives a contextdependent immune-desert microenvironment and is sensitized by immunogenic viruses by Yan, Juan, Chen, Yuedan, Warda, Amish J. Pate Sarah, Lee, Cindy J, Nixon, Briana G, Wong, Elissa W.P, Miranda-Roman, Miguel A, Yang, Ning, Wang, Yi, Pachai, Mohini R, Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Phillip M., Jr, Maag, Jesper L.V, Koche, Richard P, Zheng, Deyou, Antonescu, Cristina R, Deng, Liang, Li, Ming O, Chen, Yu, Chi, Ping

“…Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert…”
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Abstract PR005: PRC2 inactivating mutations amplify cell death in response to DNMT1-targeted therapy through enhanced viral mimicry in malignant peripheral nerve sheath tumor by Chi, Ping, Patel, Amish J., Warda, Sarah, Maag, Jesper L.V., Misra, Rohan, Miranda-Román, Miguel A., Pachai, Mohini R., Lee, Cindy J., Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W.P., Yan, Juan, Giff, Emily, Fletcher, Jonathan, Scandura, Joseph M., Koche, Richard, Glass, Jacob L., Antonescu, Cristina R., Zheng, Deyou, Chen, Yu

“…Abstract Polycomb Repressive Complex 2 (PRC2) establishes and maintains di- and tri-methylation at histone 3 at lysine 27 (H3K27me2/3) in the genome and plays…”
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Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets by Tang, Fanying, Xu, Duo, Wang, Shangqian, Wong, Chen Khuan, Martinez-Fundichely, Alexander, Lee, Cindy J., Cohen, Sandra, Park, Jane, Hill, Corinne E., Eng, Kenneth, Bareja, Rohan, Han, Teng, Liu, Eric Minwei, Palladino, Ann, Di, Wei, Gao, Dong, Abida, Wassim, Beg, Shaham, Puca, Loredana, Meneses, Maximiliano, de Stanchina, Elisa, Berger, Michael F., Gopalan, Anuradha, Dow, Lukas E., Mosquera, Juan Miguel, Beltran, Himisha, Sternberg, Cora N., Chi, Ping, Scher, Howard I., Sboner, Andrea, Chen, Yu, Khurana, Ekta

“…Abstract Untreated prostate cancers rely on androgen receptor (AR) signaling for growth and survival, forming the basis for the initial efficacy of androgen…”
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Abstract 6164: Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment by Yan, Juan, Chen, Yuedan, Patel, Amish J., Lee, Cindy J., Warda, Sarah, Nixon, Briana G., Wong, Elissa W. P., Miranda-Román, Miguel A., Yang, Ning, Wang, Yi, Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Phillip M., Maag, Jesper L., Koche, Richard P., Zheng, Deyou, Antonescu, Cristina R., Li, Ming, Deng, Liang, Chen, Yu, Chi, Ping

“…Abstract Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with significant T-cell infiltrates, but tumors with an…”
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