Search Results - "Lee, Choongil"
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Site-directed mutagenesis in Petunia × hybrida protoplast system using direct delivery of purified recombinant Cas9 ribonucleoproteins
Published in Plant cell reports (01-07-2016)“…Key message Site-directed mutagenesis of nitrate reductase genes using direct delivery of purified Cas9 protein preassembled with guide RNA produces mutations…”
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A library of TAL effector nucleases spanning the human genome
Published in Nature biotechnology (01-03-2013)“…A collection of TALENs targeted to 18,740 human protein-coding genes will facilitate genetic engineering of human cells. Transcription activator–like (TAL)…”
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Production of Mutated Porcine Embryos Using Zinc Finger Nucleases and a Reporter-based Cell Enrichment System
Published in Animal bioscience (01-03-2014)“…To facilitate the construction of genetically-modified pigs, we produced cloned embryos derived from porcine fibroblasts transfected with a pair of engineered…”
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4
Production of CMAH Knockout Preimplantation Embryos Derived From Immortalized Porcine Cells Via TALE Nucleases
Published in Molecular therapy. Nucleic acids (01-05-2014)“…Although noncancerous immortalized cell lines have been developed by introducing genes into human and murine somatic cells, such cell lines have not been…”
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CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
Published in Molecular therapy (07-08-2019)“…A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins,…”
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Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification
Published in Nucleic acids research (10-06-2022)“…Abstract MicroRNA-dependent mRNA decay plays an important role in gene silencing by facilitating posttranscriptional and translational repression. Inspired by…”
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Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells
Published in Prion (04-07-2015)“…Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study…”
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Production of Mutated Porcine Embryos Using Zinc Finger Nucleases and a Reporter-based Cell Enrichment System
Published in Asian-australasian journal of animal sciences (2014)“…To facilitate the construction of genetically-modified pigs, we produced cloned embryos derived from porcine fibroblasts transfected with a pair of engineered…”
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