Search Results - "Lee, Chang Jie Mick"

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity by Tan, Chia Yee, Chan, Pui Shi, Tan, Hansen, Tan, Sung Wei, Lee, Chang Jie Mick, Wang, Jiong-Wei, Ye, Shu, Werner, Hendrikje, Loh, Ying Jie, Lee, Yin Loon, Ackers-Johnson, Matthew, Foo, Roger S. Y, Jiang, Jianming

“…Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have…”
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Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells by Autio, Matias I, Motakis, Efthymios, Perrin, Arnaud, Bin Amin, Talal, Tiang, Zenia, Do, Dang Vinh, Wang, Jiaxu, Tan, Joanna, Ding, Shirley Suet Lee, Tan, Wei Xuan, Lee, Chang Jie Mick, Teo, Adrian Kee Keong, Foo, Roger S Y

“…Selection of the target site is an inherent question for any project aiming for directed transgene integration. Genomic safe harbour (GSH) loci have been…”
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BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation by Wong, Darren Chen Pei, Xiao, Jingwei, Chew, Ti Weng, Pan, Meng, Lee, Chang Jie Mick, Ang, Jing Wen, Yow, Ivan, Thivakar, T., Ackers‐Johnson, Matthew, Lee, Nicole Jia Wen, Foo, Roger Sik‐Yin, Kanchanawong, Pakorn, Low, Boon Chuan

“…Rho GTPases and Hippo kinases are key regulators of cardiomyoblast differentiation. However, how these signaling axes are coordinated spatiotemporally remains…”
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Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress–Gene Response by Lee, Dominic Paul, Tan, Wilson Lek Wen, Anene-Nzelu, Chukwuemeka George, Lee, Chang Jie Mick, Li, Peter Yiqing, Luu, Tuan Danh Anh, Chan, Cheryl Xueli, Tiang, Zenia, Ng, Shi Ling, Huang, Xingfan, Efthymios, Motakis, Autio, Matias I, Jiang, Jianming, Fullwood, Melissa Jane, Prabhakar, Shyam, Lieberman Aiden, Erez, Foo, Roger Sik-Yin

“…BACKGROUND:The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and cis-regulatory elements for…”
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BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) by Wong, Darren Chen Pei, Xiao, Jingwei, Chew, Ti Weng, Pan, Meng, Lee, Chang Jie Mick, Ang, Jing Wen, Yow, Ivan, Thivakar, T., Ackers‐Johnson, Matthew, Lee, Nicole Jia Wen, Foo, Roger Sik‐Yin, Kanchanawong, Pakorn, Low, Boon Chuan

“…BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the…”
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Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses by Leblanc, Francis J.A., Jin, Xuexin, Kang, Kai, Lee, Chang Jie Mick, Xu, Juan, Xuan, Lina, Ma, Wenbo, Belhaj, Hicham, Benzaki, Marouane, Mehta, Neelam, Foo, Roger Sik Yin, Reilly, Svetlana, Anene-Nzelu, Chukwuemeka George, Pan, Zhenwei, Nattel, Stanley, Yang, Baofeng, Lettre, Guillaume

“…Atrial fibrillation (AF) is the most common arrhythmia in the world. Human genetics can provide strong AF therapeutic candidates, but the identification of the…”
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TRIM35: A Proposed Gateway to p53-Induced Heart Failure Pathogenesis by Lee, Chang Jie Mick, Foo, Roger S-Y

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Ultra-Tough Graphene Oxide/DNA 2D Hydrogel with Intrinsic Sensing and Actuation Functions by Chen, Siyu, Lee, Chang Jie Mick, Tan, Gladys Shi Xuan, Ng, Pei Rou, Zhang, Pengxiang, Zhao, Jinpei, Novoselov, Kostya S, Andreeva, Daria V

“…Hydrogel devices with mechanical toughness and tunable functionalities are highly desirable for practical long-term applications such as sensing and actuation…”
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Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage by Lee, Chang Jie Mick, Autio, Matias I, Zheng, Wenhao, Song, Yoohyun, Wang, Shyi Chyi, Wong, Darren Chen Pei, Xiao, Jingwei, Zhu, Yike, Yusoff, Permeen, Yei, Xi, Chock, Wan Kee, Low, Boon Chuan, Sudol, Marius, Foo, Roger S-Y

“…Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic…”
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Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype by Tan, Wilson Lek Wen, Anene-Nzelu, Chukwuemeka George, Wong, Eleanor, Lee, Chang Jie Mick, Tan, Hui San, Tang, Sze Jing, Perrin, Arnaud, Wu, Kan Xing, Zheng, Wenhao, Ashburn, Robert John, Pan, Bangfen, Lee, May Yin, Autio, Matias Ilmari, Morley, Michael P., Tam, Wai Leong, Cheung, Christine, Margulies, Kenneth B., Chen, Leilei, Cappola, Thomas P., Loh, Marie, Chambers, John, Prabhakar, Shyam, Foo, Roger S.Y.

“…RATIONALEIdentifying genetic markers for heterogeneous complex diseases such as heart failure is challenging, and requires prohibitively large cohort sizes in…”
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Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation by Zhu, Yike, Ackers-Johnson, Matthew, Shanmugam, Muthu K, Pakkiri, Leroy Sivappiragasam, Drum, Chester Lee, Chen, Yanpu, Kim, Johnny, Paltzer, Wyatt G, Mahmoud, Ahmed I, Tan, Wilson Lek Wen, Lee, Mick Chang Jie, Jiang, Jianming, Luu, Danh Anh Tuan, Ng, Shi Ling, Li, Peter Yi Qing, Wang, Anhui, Qi, Rong, Ong, Gabriel Jing Xiang, Ng, Timothy Yu, Haigh, Jody J, Tiang, Zenia, Richards, A Mark, Foo, Roger S Y

“…Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the…”
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Assigning Distal Genomic Enhancers to Cardiac Disease–Causing Genes by Anene-Nzelu, Chukwuemeka George, Tan, Wilson Lek Wen, Lee, Chang Jie Mick, Wenhao, Zheng, Perrin, Arnaud, Dashi, Albert, Tiang, Zenia, Autio, Matias Ilmari, Lim, Bram, Wong, Eleanor, Tan, Hui San, Pan, Bangfen, Morley, Michael P., Margulies, Kenneth B., Cappola, Thomas P., Foo, Roger S-Y.

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