Search Results - "Lee, Catherine A.A."

Accelerated Aging and Microsatellite Instability in Recessive Dystrophic Epidermolysis Bullosa-Associated Cutaneous Squamous Cell Carcinoma by Lee, Catherine A A, Wu, Siyuan, Chow, Yuen Ting, Kofman, Eric, Williams, Valencia, Riddle, Megan, Eide, Cindy, Ebens, Christen L, Frank, Markus H, Tolar, Jakub, Hook, Kristen P, AlDubayan, Saud H, Frank, Natasha Y

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a severely debilitating disorder caused by pathogenic variants in COL7A1 and is characterized by extreme…”
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Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism by Lee, Catherine A.A., Banerjee, Pallavi, Wilson, Brian J., Wu, Siyuan, Guo, Qin, Berg, Gretchen, Karpova, Svetlana, Mishra, Ananda, Lian, John W., Tran, Johnathan, Emmerich, Max, Murphy, George F., Frank, Markus H., Frank, Natasha Y.

“…Glioblastoma multiforme (GBM) is a malignant brain tumor with a poor prognosis resulting from tumor resistance to anticancer therapy and a high recurrence…”
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Insights from immunoproteomic profiling of a rejected full-face transplant by Lee, Catherine A.A., Wang, Diana, Kauke-Navarro, Martin, Russell-Goldman, Eleanor, Xu, Shuyun, Mucciarone, Kyla N., Sohrabi, Sadaf, Lian, Christine G., Pomahac, Bohdan, Murphy, George F.

“…Vascularized composite allografts (VCAs) of faces and extremities are subject to chronic rejection that is incompletely understood. Here we report on…”
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Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice by Collier, Jenna L, Pauken, Kristen E, Lee, Catherine A A, Patterson, Dillon G, Markson, Samuel C, Conway, Thomas S, Fung, Megan E, France, Joshua A, Mucciarone, Kyla N, Lian, Christine G, Murphy, George F, Sharpe, Arlene H

“…Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer immunotherapy. A better understanding of how these iatrogenic diseases compare…”
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Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation by Li, Feng, Yuan, Christine W., Xu, Shuyun, Zu, Tingjian, Woappi, Yvon, Lee, Catherine A.A., Abarzua, Phammela, Wells, Michael, Ramsey, Matthew R., Frank, Natasha Y., Wu, Xunwei, Mandinova, Anna, Frank, Markus H., Lian, Christine G., Murphy, George F.

“…Epigenetic regulation has a profound influence on stem cell fate during normal development in maintenance of physiologic tissue homeostasis. Here we report…”
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3D-Printed ABCB5-Positive Stem Cells for the Treatment of Corneal Blindness by Lee, Catherine A.A., Karpova, Catherine S., Rozbu, Mahtabin R., Lee, Wonhye, Kunes, Jennifer A., Ksander, Bruce R., Frank, Markus H., Yoo, Seung-Schik S., Frank, Natasha Y.

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ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways by Zu, Tingjian, Wang, Diana, Xu, Shuyun, Lee, Catherine A.A., Zhen, Ellen, Yoon, Charles H., Abarzua, Phammela, Wang, Shuangshuang, Frank, Natasha Y., Wu, Xunwei, Lian, Christine G., Murphy, George F.

“…Activating transcription factor 3 (ATF-3), a cyclic AMP-dependent transcription factor, has been shown to play a regulatory role in melanoma, although its…”
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Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation by Kauke-Navarro, Martin, Sadigh, Sam, Lee, Catherine A.A., Panayi, Adriana C., Knoedler, Leonard, Knoedler, Samuel, Stoegner, Viola, Huelsboemer, Lioba, Jamil, Azzi, Ko, Christine, Lian, Christine G., Murphy, George F., Pomahac, Bohdan

“…Apart from the skin, little is known about the immunological processes in deeper tissues, which are typically not accessible to biopsy and inspection, of…”
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Epigenetic Regulation of Corneal Epithelial Differentiation by TET2 by Sasamoto, Yuzuru, Wu, Siyuan, Lee, Catherine A A, Jiang, Jason Y, Ksander, Bruce R, Frank, Markus H, Frank, Natasha Y

“…Epigenetic DNA modification by 5-hydroxymethylcytosine (5hmC), generated by the Ten-eleven translocation (TET) dioxygenases, regulates diverse biological…”
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A multitask clustering approach for single-cell RNA-seq analysis in Recessive Dystrophic Epidermolysis Bullosa by Zhang, Huanan, Lee, Catherine A A, Li, Zhuliu, Garbe, John R, Eide, Cindy R, Petegrosso, Raphael, Kuang, Rui, Tolar, Jakub

“…Single-cell RNA sequencing (scRNA-seq) has been widely applied to discover new cell types by detecting sub-populations in a heterogeneous group of cells. Since…”
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Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation by Sasamoto, Yuzuru, Lee, Catherine A.A., Wilson, Brian J., Buerger, Florian, Martin, Gabrielle, Mishra, Ananda, Kiritoshi, Shoko, Tran, Johnathan, Gonzalez, Gabriel, Hildebrandt, Friedhelm, Jo, Vickie Y., Lian, Christine G., Murphy, George F., Ksander, Bruce R., Frank, Markus H., Frank, Natasha Y.

“…The corneal epithelium is renowned for high regenerative potential, which is dependent on the coordinated function of its diverse progenitor subpopulations…”
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Cellular activation pathways and interaction networks in vascularized composite allotransplantation by Knoedler, Leonard, Knoedler, Samuel, Panayi, Adriana C, Lee, Catherine A A, Sadigh, Sam, Huelsboemer, Lioba, Stoegner, Viola A, Schroeter, Andreas, Kern, Barbara, Mookerjee, Vikram, Lian, Christine G, Tullius, Stefan G, Murphy, George F, Pomahac, Bohdan, Kauke-Navarro, Martin

“…Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with…”
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High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells by Sasamoto, Yuzuru, Lee, Catherine A.A., Yoshihara, Masahito, Martin, Gabrielle, Ksander, Bruce R., Frank, Markus H., Frank, Natasha Y.

“…Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). While the ocular surface is considered one of the…”
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Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients by Lee, Catherine A A, Seo, Hannah S, Armien, Anibal G, Bates, Frank S, Tolar, Jakub, Azarin, Samira M

“…X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene. 40% of X-ALD patients will convert to the deadly childhood cerebral form…”
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Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells by Gerton, Thomas J, Green, Allen, Campisi, Marco, Chen, Minyue, Gjeci, Iliana, Mahadevan, Navin, Lee, Catherine A A, Mishra, Ranjan, Vo, Ha V, Haratani, Koji, Li, Ze-Hua, Hasselblatt, Kathleen T, Testino, Bryanna, Connor, Trevor, Lian, Christine G, Elias, Kevin M, Lizotte, Patrick, Ivanova, Elena V, Barbie, David A, Dinulescu, Daniela M

“…High-grade serous ovarian cancer (HGSOC) is responsible for the majority of gynecology cancer-related deaths. Patients in remission often relapse with more…”
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