Search Results - "Lee, Brian R."
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Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections
Published in Neuron (Cambridge, Mass.) (17-09-2014)“…Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent…”
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Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
Published in Journal of visualized experiments (26-02-2018)“…This protocol is a practical guide to the N-methyl-D-glucamine (NMDG) protective recovery method of brain slice preparation. Numerous recent studies have…”
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3
Alternating sources of perisomatic inhibition during behavior
Published in Neuron (Cambridge, Mass.) (17-03-2021)“…Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the…”
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Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine
Published in Proceedings of the National Academy of Sciences - PNAS (08-01-2013)“…The nucleus accumbens (NAc) regulates motivated behavior by, in part, processing excitatory synaptic projections from several brain regions. Among these…”
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Antimicrobial stewardship programs in freestanding children's hospitals
Published in Pediatrics (Evanston) (01-01-2015)“…Single-center evaluations of pediatric antimicrobial stewardship programs (ASPs) suggest that ASPs are effective in reducing and improving antibiotic…”
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Assessing environmental injustice in Kansas City by linking paediatric asthma to local sources of pollution: a cross-sectional study
Published in BMJ open (17-07-2024)“…ObjectiveA grassroots environmental-justice organisation in Kansas City has been examining the disproportionate exposure to air pollution experienced by…”
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In Vivo Cocaine Experience Generates Silent Synapses
Published in Neuron (Cambridge, Mass.) (16-07-2009)“…Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little…”
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The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker
Published in Clinical and translational science (01-03-2024)“…The phenotypical manifestations of asthma among children are diverse and exhibit varying responses to therapeutic interventions. There is a need to develop…”
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A silent synapse-based mechanism for cocaine-induced locomotor sensitization
Published in The Journal of neuroscience (01-06-2011)“…Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes…”
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A pilot intervention combining assessment and feedback with communication training and behavioral nudges to increase HPV vaccine uptake
Published in Human vaccines & immunotherapeutics (31-12-2022)“…Human papillomavirus (HPV) causes >40,000 cancer diagnoses each year, yet vaccination rates remain low because widespread implementation of strategies to…”
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Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types
Published in Nature communications (13-07-2023)“…GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap…”
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Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
Published in eLife (30-05-2023)“…Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these…”
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Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization
Published in eLife (13-08-2021)“…The Patch-seq approach is a powerful variation of the patch-clamp technique that allows for the combined electrophysiological, morphological, and…”
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Morpho-electric diversity of human hippocampal CA1 pyramidal neurons
Published in Cell reports (Cambridge) (23-04-2024)“…Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known…”
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Variability in Antibiotic Use Across PICUs
Published in Pediatric critical care medicine (01-06-2018)“…To characterize and compare antibiotic prescribing across PICUs to evaluate the degree of variability. Retrospective analysis from 2010 through 2014 of the…”
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Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons
Published in Cell reports (Cambridge) (24-09-2024)“…Large-scale analysis of single-cell gene expression has revealed transcriptomically defined cell subclasses present throughout the primate neocortex with gene…”
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Let’s Talk About Antibiotics: a randomised trial of two interventions to reduce antibiotic misuse
Published in BMJ open (21-11-2022)“…BackgroundChildren with acute respiratory tract infections (ARTIs) receive ≈11.4 million unnecessary antibiotic prescriptions annually. A noted contributor is…”
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School knowledge of infectious diseases in schools: conducting surveillance and on-demand, symptomatic respiratory viral testing in a large pre-kindergarten-12th grade school district
Published in Frontiers in public health (23-07-2024)“…Limited data about acute respiratory illness (ARI) and respiratory virus circulation are available in congregate community settings, specifically schools. To…”
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Variation in ampicillin dosing for lower respiratory tract infections and neonatal bacterial infections in US children's hospitals
Published in Antimicrobial stewardship & healthcare epidemiology : ASHE (2022)“…We examined ampicillin dosing in pediatric patients across 3 conditions: (1) bacterial lower respiratory tract infections (LRTIs) in infants and children >3…”
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Characteristics of antifungal utilization for hospitalized children in the United States
Published in Antimicrobial stewardship & healthcare epidemiology : ASHE (2022)“…To characterize antifungal prescribing patterns, including the indication for antifungal use, in hospitalized children across the United States. We analyzed…”
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