Search Results - "Lee, Andrew Chak Yiu"

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters by Yuan, Shuofeng, Wang, Runming, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Cheng, Tianfan, Chik, Kenn Ka-Heng, Ye, Zi-Wei, Wang, Suyu, Lee, Andrew Chak-Yiu, Jin, Lijian, Li, Hongyan, Jin, Dong-Yan, Yuen, Kwok-Yung, Sun, Hongzhe

“…SARS-CoV-2 is causing a pandemic of COVID-19, with high infectivity and significant mortality 1 . Currently, therapeutic options for COVID-19 are limited…”
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Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein by Wang, Pui, Lau, Siu-Ying, Deng, Shaofeng, Chen, Pin, Mok, Bobo Wing-Yee, Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chan, Kwok-Hung, Tam, Rachel Chun-Yee, Xu, Haoran, Zhou, Runhong, Song, Wenjun, Liu, Li, To, Kelvin Kai-Wang, Chan, Jasper Fuk-Woo, Chen, Zhiwei, Yuen, Kwok-Yung, Chen, Honglin

“…SARS-CoV-2 is of zoonotic origin and contains a PRRA polybasic cleavage motif which is considered critical for efficient infection and transmission in humans…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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SARS-CoV-2 infects human neural progenitor cells and brain organoids by Zhang, Bao-Zhong, Chu, Hin, Han, Shuo, Shuai, Huiping, Deng, Jian, Hu, Ye-fan, Gong, Hua-rui, Lee, Andrew Chak-Yiu, Zou, Zijiao, Yau, Thomas, Wu, Wutian, Hung, Ivan Fan-Ngai, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung, Huang, Jian-Dong

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Attenuated Interferon and Proinflammatory Response in SARS-CoV-2–Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation by Yang, Dong, Chu, Hin, Hou, Yuxin, Chai, Yue, Shuai, Huiping, Lee, Andrew Chak-Yiu, Zhang, Xi, Wang, Yixin, Hu, Bingjie, Huang, Xiner, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Zhou, Jie, Yuan, Shuofeng, Zhang, Anna Jinxia, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

“…Abstract Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with…”
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Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19) by Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Zhang, Anna Jinxia, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Fan, Zhimeng, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Luo, Cuiting, Cheng, Vincent Chi-Chung, Cai, Jian-Piao, Chu, Hin, Chan, Kwok-Hung, To, Kelvin Kai-Wang, Sridhar, Siddharth, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be mostly…”
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Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 by Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung

“…The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chu, Hin, Chan, Jasper Fuk-Woo, Fan, Zhimeng, Li, Can, Liu, Feifei, Chen, Yanxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Wu, Kenneth Lap-Kei, Sridhar, Siddharth, Chan, Ying-Shing, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) is primarily an acute respiratory tract infection. Distinctively, a substantial proportion of COVID-19…”
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Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chan, Jasper Fuk-Woo, Liu, Feifei, Li, Can, Chen, Yanxia, Chu, Hin, Lau, Siu-Ying, Wang, Pui, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung

“…Abstract Background Clinical outcomes of the interaction between the co-circulating pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and…”
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Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction by Lau, Siu-Ying, Wang, Pui, Mok, Bobo Wing-Yee, Zhang, Anna Jinxia, Chu, Hin, Lee, Andrew Chak-Yiu, Deng, Shaofeng, Chen, Pin, Chan, Kwok-Hung, Song, Wenjun, Chen, Zhiwei, To, Kelvin Kai-Wang, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung, Chen, Honglin

“…The emergence of SARS-CoV-2 has led to the current global coronavirus pandemic and more than one million infections since December 2019. The exact origin of…”
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Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges by Lee, Andrew Chak-Yiu, Zhang, Anna Jinxia, Li, Can, Chen, Yanxia, Liu, Feifei, Zhao, Yan, Chu, Hin, Fong, Carol Ho-Yan, Wang, Pui, Lau, Siu-Ying, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung

“…We previously developed a temperature-sensitive, and NS1 gene deleted live attenuated influenza vaccine (DelNS1-LAIV) and demonstrated its potent protective…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage by Li, Can, Ye, Zhanhong, Zhang, Anna Jin Xia, Chan, Jasper Fuk Woo, Song, Wenchen, Liu, Feifei, Chen, Yanxia, Kwan, Mike Yat Wah, Lee, Andrew Chak Yiu, Zhao, Yan, Wong, Bosco Ho Yin, Yip, Cyril Chik Yan, Cai, Jian Piao, Lung, David Christopher, Sridhar, Siddharth, Jin, Dongyan, Chu, Hin, To, Kelvin Kai Wang, Yuen, Kwok Yung

“…Abstract Background The role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathogenesis of testicular damage is uncertain. Methods We…”
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An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models by Yuen, Chun-Kit, Wong, Wan-Man, Mak, Long-Fung, Lam, Joy-Yan, Cheung, Lok-Yi, Cheung, Derek Tsz-Yin, Ng, Yau-Yee, Lee, Andrew Chak-Yiu, Zhong, Nanshan, Yuen, Kwok-Yung, Kok, Kin-Hang

“…A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential future beta-coronavirus infections is important for fighting possible…”
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Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters by Lee, Andrew Chak-Yiu, Zhang, Anna Jinxia, Chan, Jasper Fuk-Woo, Li, Can, Fan, Zhimeng, Liu, Feifei, Chen, Yanxia, Liang, Ronghui, Sridhar, Siddharth, Cai, Jian-Piao, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, To, Kelvin Kai-Wang, Yuan, Shuofeng, Zhou, Jie, Chu, Hin, Yuen, Kwok-Yung

“…Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is transmitted largely by respiratory droplets or airborne aerosols. Despite being frequently…”
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Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review by Chung, Tom Wai-Hin, Sridhar, Siddharth, Zhang, Anna Jinxia, Chan, Kwok-Hung, Li, Hang-Long, Wong, Fergus Kai-Chuen, Ng, Ming-Yen, Tsang, Raymond King-Yin, Lee, Andrew Chak-Yiu, Fan, Zhimeng, Ho, Ronnie Siu-Lun, Luk, Shiobhon Yiu, Kan, Wai-Kuen, Lam, Sonia Hiu-Yin, Wu, Alan Ka-Lun, Leung, Sau-Man, Chan, Wai-Ming, Ng, Pauline Yeung, To, Kelvin Kai-Wang, Cheng, Vincent Chi-Chung, Lung, Kwok-Cheung, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung

“…Abstract Background Olfactory dysfunction (OD) has been reported in coronavirus disease 2019 (COVID-19). However, there are knowledge gaps about the severity,…”
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Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters by Li, Can, Song, Wenchen, Chan, Jasper Fuk-Woo, Chen, Yanxia, Liu, Feifei, Ye, Zhanhong, Lam, Alvin Hiu-Chung, Cai, Jianpiao, Lee, Andrew Chak-Yiu, Wong, Bosco Ho-Yin, Chu, Hin, Lung, David Christopher, Sridhar, Siddharth, Chen, Honglin, Zhang, Anna Jin-Xia, Yuen, Kwok-Yung

“…Children infected by SARS-CoV-2 Omicron variant may develop neurological complications. To study the pathogenesis in the growing brain, we intranasally…”
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STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells by Yang, Dong, Chu, Hin, Lu, Gang, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Zhang, Xi, Huang, Xiner, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Zhao, Xiaoyu, Lee, Andrew Chak-Yiu, Ye, Ziwei, Li, Cun, Chik, Kenn Ka-Heng, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Chan, Jasper Fuk-Woo

“…Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that poses significant threats to global public health. Macrophages and dendritic cells are both key…”
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Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine by Lu, Lu, Fong, Carol Ho-Yan, Zhang, Anna Jinxia, Wu, Wai-Lan, Li, Iris Can, Lee, Andrew Chak-Yiu, Dissanayake, Thrimendra Kaushika, Chen, Linlei, Hung, Ivan Fan-Ngai, Chan, Kwok-Hung, Chu, Hin, Kok, Kin-Hang, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…We previously reported that topical imiquimod can improve the immunogenicity of the influenza vaccine. This study investigated another FDA-approved drug,…”
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Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways by Chu, Hin, Zhou, Jie, Wong, Bosco Ho-Yin, Li, Cun, Chan, Jasper Fuk-Woo, Cheng, Zhong-Shan, Yang, Dong, Wang, Dong, Lee, Andrew Chak-Yiu, Li, Chuangen, Yeung, Man-Lung, Cai, Jian-Piao, Chan, Ivy Hau-Yee, Ho, Wai-Kuen, To, Kelvin Kai-Wang, Zheng, Bo-Jian, Yao, Yanfeng, Qin, Chuan, Yuen, Kwok-Yung

“…Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human…”
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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation by Ho, Jessica Sook Yuin, Mok, Bobo Wing-Yee, Campisi, Laura, Jordan, Tristan, Yildiz, Soner, Parameswaran, Sreeja, Wayman, Joseph A., Gaudreault, Natasha N., Meekins, David A., Indran, Sabarish V., Morozov, Igor, Trujillo, Jessie D., Fstkchyan, Yesai S., Rathnasinghe, Raveen, Zhu, Zeyu, Zheng, Simin, Zhao, Nan, White, Kris, Ray-Jones, Helen, Malysheva, Valeriya, Thiecke, Michiel J., Lau, Siu-Ying, Liu, Honglian, Zhang, Anna Junxia, Lee, Andrew Chak-Yiu, Liu, Wen-Chun, Jangra, Sonia, Escalera, Alba, Aydillo, Teresa, Melo, Betsaida Salom, Guccione, Ernesto, Sebra, Robert, Shum, Elaine, Bakker, Jan, Kaufman, David A., Moreira, Andre L., Carossino, Mariano, Balasuriya, Udeni B.R., Byun, Minji, Albrecht, Randy A., Schotsaert, Michael, Garcia-Sastre, Adolfo, Chanda, Sumit K., Miraldi, Emily R., Jeyasekharan, Anand D., TenOever, Benjamin R., Spivakov, Mikhail, Weirauch, Matthew T., Heinz, Sven, Chen, Honglin, Benner, Christopher, Richt, Juergen A., Marazzi, Ivan

“…The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large…”
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