Search Results - "Lee, Amy S.Y."

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling by Kranzusch, Philip J., Wilson, Stephen C., Lee, Amy S.Y., Berger, James M., Doudna, Jennifer A., Vance, Russell E.

“…In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2′,3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed…”
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Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity by Kranzusch, Philip J., Lee, Amy S.Y., Wilson, Stephen C., Solovykh, Mikhail S., Vance, Russell E., Berger, James M., Doudna, Jennifer A.

“…Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic…”
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Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity by Nuñez, James K., Lee, Amy S. Y., Engelman, Alan, Doudna, Jennifer A.

“…Bacteria and archaea insert spacer sequences acquired from foreign DNAs into CRISPR loci to generate immunological memory. The Escherichia coli Cas1–Cas2…”
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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation by Lee, Amy S. Y., Kranzusch, Philip J., Doudna, Jennifer A., Cate, Jamie H. D.

“…The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d…”
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eIF3 targets cell-proliferation messenger RNAs for translational activation or repression by Lee, Amy S. Y., Kranzusch, Philip J., Cate, Jamie H. D.

“…Eukaryotic initiation factor 3 (eIF3)—the deregulation of which has been linked with diverse cancers—is shown to bind to and direct the specialized translation…”
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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy by Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

“…High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed…”
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eIF3d controls the persistent integrated stress response by Mukhopadhyay, Shaoni, Amodeo, Maria E., Lee, Amy S.Y.

“…Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and activating gene programs necessary for survival. Here, we show that…”
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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals by Whiteley, Aaron T., Eaglesham, James B., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Lowey, Brianna, Nieminen, Eric A., Danilchanka, Olga, King, David S., Lee, Amy S. Y., Mekalanos, John J., Kranzusch, Philip J.

“…Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit…”
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cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila by Slavik, Kailey M., Morehouse, Benjamin R., Ragucci, Adelyn E., Zhou, Wen, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Bähre, Heike, König, Martin, Seifert, Roland, Lee, Amy S. Y., Cai, Hua, Imler, Jean-Luc, Kranzusch, Philip J.

“…Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2′–5′]pA[3′–5′]p (2′3′-cGAMP) and controls activation of innate…”
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Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes by Farache, Dorian, Liu, Luochen, Lee, Amy S.Y.

“…[Display omitted] •In the eIF5A family, eIF5A1 regulates mRNA translation, while the molecular function of eIF5A2 is unknown.•We find that eIF5A2 does not…”
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CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection by Lowey, Brianna, Whiteley, Aaron T., Keszei, Alexander F.A., Morehouse, Benjamin R., Mathews, Ian T., Antine, Sadie P., Cabrera, Victor J., Kashin, Dmitry, Niemann, Percy, Jain, Mohit, Schwede, Frank, Mekalanos, John J., Shao, Sichen, Lee, Amy S.Y., Kranzusch, Philip J.

“…cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in…”
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Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation by de Oliveira Mann, Carina C., Orzalli, Megan H., King, David S., Kagan, Jonathan C., Lee, Amy S.Y., Kranzusch, Philip J.

“…Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer…”
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Moonlighting translation factors: multifunctionality drives diverse gene regulation by Farache, Dorian, Antine, Sadie P., Lee, Amy S.Y.

“…Translation factors have traditionally been viewed as proteins that drive ribosome function and ensure accurate mRNA translation. Recent discoveries have…”
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A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress by Lamper, Adam M, Fleming, Rebecca H, Ladd, Kayla M, Lee, Amy S Y

“…Shutoff of global protein synthesis is a conserved response to cellular stresses. This general phenomenon is accompanied by the induction of distinct gene…”
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Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity by Dixit, Evelyn, Boulant, Steeve, Zhang, Yijing, Lee, Amy S.Y., Odendall, Charlotte, Shum, Bennett, Hacohen, Nir, Chen, Zhijian J., Whelan, Sean P., Fransen, Marc, Nibert, Max L., Superti-Furga, Giulio, Kagan, Jonathan C.

“…Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert…”
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A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion by Richmond-Buccola, Desmond, Hobbs, Samuel J, Garcia, Jasmine M, Toyoda, Hunter, Gao, Jingjing, Shao, Sichen, Lee, Amy S Y, Kranzusch, Philip J

“…Cyclic oligonucleotide-based signaling system (CBASS) is an antiviral system that protects bacteria from phage infection and is evolutionarily related to human…”
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A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents by Blower, Tim R, Bandak, Afif, Lee, Amy S Y, Austin, Caroline A, Nitiss, John L, Berger, James M

“…Abstract Type II topoisomerases catalyze essential DNA transactions and are proven drug targets. Drug discrimination by prokaryotic and eukaryotic…”
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eIF3 targets cell proliferation mRNAs for translational activation or repression by Lee, Amy S.Y., Kranzusch, Philip J., Cate, Jamie H.D.

“…Regulation of protein synthesis is fundamental for all aspects of eukaryotic biology by controlling development, homeostasis, and stress responses 1 , 2 . The…”
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A molecular filter for the cnidarian stinging response by Weir, Keiko, Dupre, Christophe, van Giesen, Lena, Lee, Amy S-Y, Bellono, Nicholas W

“…All animals detect and integrate diverse environmental signals to mediate behavior. Cnidarians, including jellyfish and sea anemones, both detect and capture…”
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eIF3d is an mRNA cap-binding protein required for specialized translation initiation by Lee, Amy S.Y., Kranzusch, Philip J., Doudna, Jennifer A., Cate, Jamie H.D.

“…Eukaryotic mRNAs contain a 5' cap structure critical for recruitment of the translation machinery and initiation of protein synthesis. mRNA recognition is…”
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