Search Results - "Lee, Amy S."

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential by Lee, Amy S.

“…Key Points The glucose-regulated proteins (GRPs) GRP78, GRP94, GRP170 and GRP75, are members of the heat shock protein family. They primarily reside in the…”
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Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis by Zhu, Genyuan, Lee, Amy S.

“…The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane proteins, as well as lipids, are synthesized and modified. When cells are…”
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GRP78 induction in cancer : Therapeutic and prognostic implications by LEE, Amy S

“…Cancer cells adapt to chronic stress in the tumor microenvironment by inducing the expression of GRP78/BiP, a major endoplasmic reticulum chaperone with…”
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Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting by Ni, Min, Zhang, Yi, Lee, Amy S

“…GRP78 (glucose-regulated protein of 78 kDa) is traditionally regarded as a major ER (endoplasmic reticulum) chaperone facilitating protein folding and…”
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ER chaperones in mammalian development and human diseases by Ni, Min, Lee, Amy S.

“…The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly during the past decade, contributing to understanding of the molecular…”
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The critical role of GRP78 in physiologic and pathologic stress by Pfaffenbach, Kyle T, Lee, Amy S

“…GRP78 is a major endoplasmic reticulum chaperone as well as a master regulator of the unfolded protein response. In addition to playing an essential role in…”
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The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection by Carlos, Anthony J., Ha, Dat P., Yeh, Da-Wei, Van Krieken, Richard, Tseng, Chun-Chih, Zhang, Pu, Gill, Parkash, Machida, Keigo, Lee, Amy S.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 global pandemic, utilizes the host receptor…”
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Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity by Dixit, Evelyn, Boulant, Steeve, Zhang, Yijing, Lee, Amy S.Y., Odendall, Charlotte, Shum, Bennett, Hacohen, Nir, Chen, Zhijian J., Whelan, Sean P., Fransen, Marc, Nibert, Max L., Superti-Furga, Giulio, Kagan, Jonathan C.

“…Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert…”
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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation by Lee, Amy S. Y., Kranzusch, Philip J., Doudna, Jennifer A., Cate, Jamie H. D.

“…The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d…”
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Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis by Borok, Zea, Horie, Masafumi, Flodby, Per, Wang, Hongjun, Liu, Yixin, Ganesh, Sivagini, Firth, Amy L, Minoo, Parviz, Li, Changgong, Beers, Michael F, Lee, Amy S, Zhou, Beiyun

“…Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the pathogenesis of pulmonary fibrosis. Endoplasmic reticulum (ER) stress in…”
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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress by Lee, Amy S.

“…The multiple implications of ER stress and the unfolded protein response in health and disease highlight the importance of identifying convenient monitoring…”
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The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein by Shin, Woo-Jin, Ha, Dat P., Machida, Keigo, Lee, Amy S.

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GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation by Poirier, Steve, Mamarbachi, Maya, Chen, Wan-Ting, Lee, Amy S., Mayer, Gaetan

“…Clearance of circulating low-density lipoprotein cholesterol (LDLc) by hepatic LDL receptors (LDLR) is central for vascular health. Secreted by hepatocytes,…”
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Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP by Zhang, Yi, Liu, Ren, Ni, Min, Gill, Parkash, Lee, Amy S.

“…The recent discovery that GRP78/BiP, a typical endoplasmic reticulum (ER) lumenal chaperone, can be expressed on the cell surface, interacting with an…”
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Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface by Tsai, Yuan-Li, Zhang, Yi, Tseng, Chun-Chih, Stanciauskas, Ramunas, Pinaud, Fabien, Lee, Amy S.

“…Glucose-regulated protein (GRP78)/BiP, a major chaperone in the endoplasmic reticulum, is recently discovered to be preferably expressed on the surface of…”
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Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders by Wang, Miao, Wey, Shiuan, Zhang, Yi, Ye, Risheng, Lee, Amy S

“…GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER, as well as controlling the activation of the…”
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GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis by YONG FU, JIANZE LI, LEE, Amy S

“…The recent development of hormonal therapy that blocks estrogen synthesis represents a major advance in the treatment of estrogen receptor-positive breast…”
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Ortholog of autism candidate gene RBM27 regulates mitoribosomal assembly factor MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment by Chowdhury, Tamjid A, Luy, David A, Scapellato, Garrett, Farache, Dorian, Lee, Amy S Y, Quinn, Christopher C

“…Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and attention-deficit…”
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The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells by Tseng, Chun-Chih, Zhang, Pu, Lee, Amy S.

“…Translocation of 78-kDa glucose-regulated protein (GRP78) from endoplasmic reticulum (ER) to plasma membrane represents a paradigm shift beyond its traditional…”
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The glucose-regulated proteins: stress induction and clinical applications by Lee, Amy S

“…A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp)…”
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