Early-life Upper Airway Microbiota are Associated with Decreased Lower Respiratory Tract Infections

Microbial interactions mediating colonization resistance play key roles within the human microbiome, shaping susceptibility to infection from birth. To gain insight into microbiome-mediated defenses and respiratory pathogen colonization dynamics, we sequenced and analyzed nasal (n=229) and oral (n=2...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology
Main Authors:	Zelasko, Susan, Swaney, Mary Hannah, Sandstrom, Shelby, Lee, Kristine E., Dixon, Jonah, Riley, Colleen, Watson, Lauren, Godfrey, Jared J., Ledrowski, Naomi, Rey, Federico, Safdar, Nasia, Seroogy, Christine M., Gern, James E., Kalan, Lindsay, Currie, Cameron
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 13-11-2024
Subjects:	asthma children Moraxella catarrhalis Nasal microbiome oral microbiome pediatric pneumonia Prevotella respiratory tract infection wheezing Nasal microbiome pneumonia children oral microbiome Moraxella catarrhalis Prevotella asthma respiratory tract infection wheezing pediatric
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Summary:	Microbial interactions mediating colonization resistance play key roles within the human microbiome, shaping susceptibility to infection from birth. To gain insight into microbiome-mediated defenses and respiratory pathogen colonization dynamics, we sequenced and analyzed nasal (n=229) and oral (n=210) microbiomes with associated health/environmental data from our Wisconsin Infant Study Cohort at age 24-months. Participants with early-life lower respiratory tract infection (LRTI) were more likely to be formula-fed, attend daycare, and experience wheezing. Shotgun metagenomic sequencing with detection of viral and bacterial respiratory pathogens revealed nasal microbiome composition to associate with prior LRTI – namely lower alpha diversity, depletion of Prevotella, and enrichment of Moraxella catarrhalis including drug-resistant strains. Prevotella originating from healthy microbiomes had higher biosynthetic gene cluster abundance and exhibited contact-independent inhibition of M. catarrhalis, suggesting interbacterial competition impacts nasal pathogen colonization. This work advances understanding of protective host-microbial interactions occurring in airway microbiomes that alter infection susceptibility in early-life.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2024.11.008