Search Results - "Ledoussal, B"

Quinolone Resistance in Staphylococci: Activities of New Nonfluorinated Quinolones against Molecular Targets in Whole Cells and Clinical Isolates by ROYCHOUDHURY, Siddhartha, CATRENICH, Carl E, MCINTOSH, Eric J, MCKEEVER, Helana D, MAKIN, Kelly M, KOENIGS, Paula M, LEDOUSSAL, Benoit

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Staphylococcus aureus Mutants Isolated via Exposure to Nonfluorinated Quinolones: Detection of Known and Unique Mutations by ROYCHOUDHURY, Siddhartha, TWINEM, Tracy L, MAKIN, Kelly M, NIENABER, Mark A, CHUIYING LI, MORRIS, Timothy W, LEDOUSSAL, Benoit, CATRENICH, Carl E

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Activity of non-fluorinated quinolones (NFQs) against quinolone-resistant Escherichia coli and Streptococcus pneumoniae by Roychoudhury, Siddhartha, Twinem, Tracy L., Makin, Kelly M., McIntosh, Eric J., Ledoussal, Benoit, Catrenich, Carl E.

“…The newly developed 8-methoxy, non-fluorinated quinolones (NFQs) were studied to elucidate their enzyme inhibitory activity against wild-type and mutant GyrA…”
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Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids by Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Ledoussal, B, Remuzon, P, Kessler, R. E, Fung-Tomc, J

“…A series of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acids have been prepared and tested for their in vitro…”
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Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives by Remuzon, P, Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Kiechel, J. R, Ledoussal, B, Kessler, R. E, Fung-Tomc, J

“…A series of novel N-1-(mono-,-(di- and -(trifluoro-tert-butyl)quinolones and -naphthyridines has been prepared. Structure-activity relationship (SAR) studies…”
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Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones by Di Cesare, P, Bouzard, D, Essiz, M, Jacquet, J. P, Ledoussal, B, Kiechel, J. R, Remuzon, P, Kessler, R. E, Fung-Tomc, J, Desiderio, J

“…A series of novel 7-substituted-1-tert-butyl-6-fluoronaphthyridone-3- carboxylic acids has been prepared. These derivatives are characterized by chiral…”
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Non-fluorinated quinolones (NFQs): new antibacterials with unique properties against quinolone-resistant gram-positive pathogens by Roychoudhury, Siddhartha, Ledoussal, Benoit

“…Wide variations in the antibacterial potency and spectrum of quinolones are presumably attributable, in part, to their variable potency against the molecular…”
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Synthesis of trans-(3S)-Amino-(4R)-alkyl- and -(4S)-Aryl-piperidines via Ring-Closing Metathesis Reaction by Hu, X. Eric, Kim, Nick K, Ledoussal, Benoit

“…trans-(3S)-Amino piperidines bearing various alkyl and aryl substituents at the C-4 position were synthesized via a ring-closing metathesis reaction. The…”
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Discovery of (3S)-Amino-(4R)-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens by Hu, X. Eric, Kim, Nick K, Gray, Jeffrey L, Almstead, Ji-In K, Seibel, William L, Ledoussal, Benoit

“…Novel quinolone antibacterial agents bearing (3S)-amino-(4R)-ethylpiperidines were designed by using low energy conformation analysis and synthesized by…”
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Regio- and stereo-controlled copper organometallic addition to a piperidinyl aziridine: synthesis of trans 3-amino-4-alkyl-piperidines by Hu, X.Eric, Kim, Nick K, Ledoussal, Benoit, Colson, Anny-Odile

“…3,4-Piperidinyl aziridine N-phosphonate underwent ring opening in Grignard addition catalyzed by a copper reagent to yield trans 3-amino-4-alkyl-piperidines…”
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Synthesis and biological testing of non-Fluorinated analogues of levofloxacin by Gray, Jeffrey L., Almstead, Ji-In K., Gallagher, Corey P., Hu, X.Eric, Kim, Nick K., Taylor, Cynthia J., Twinem, Tracy L., Wallace, Cynthia D., Ledoussal, Benoit

“…Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the…”
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Potent non-6-fluoro-substituted quinolone antibacterials: synthesis and biological activity by Ledoussal, Benoit, Bouzard, Daniel, Coroneos, Evangelos

“…In this communication we describe the synthesis and biological activity of a series of 7-(aminopyrrolidinyl)-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinec…”
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Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones by Macinga, David R, Renick, Paul J, Makin, Kelly M, Ellis, David H, Kreiner, Allison A, Li, Min, Rupnik, Kirk J, Kincaid, Erica M, Wallace, Cynthia D, Ledoussal, Benoit, Morris, Timothy W

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An investigation into the total synthesis of clerocidin: stereoselective synthesis of a clerodane intermediate by Almstead, Ji-In Kim, Demuth, Thomas P., Ledoussal, Benoit

“…A key clerodane intermediate was prepared during the investigation of the total synthesis of clerocidin. The diterpene backbone was synthesized by an…”
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Fluoronaphthyridines and -quinolones as antibacterial agents. V: Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones by DI CESARE, P, BOUZARD, D, ESSIZ, M, JACQUET, J. P, LEDOUSSAL, B, KIECHEL, J. R, REMUZON, P, KESSLER, R. E, FUNG-TOMC, J, DESIDERIO, J

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Fluoronaphthyridines as antibacterial agents. IV: Synthesis and structure-activity relationships of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids by BOUZARD, D, DI CESARE, P, ESSIZ, M, JACQUET, J. P, LEDOUSSAL, B, REMUZON, P, KESSLER, R. E, FUNG-TOMC, J

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Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1(1-methyl-1-(fluoromethyl)-2-fluoroethyl), and 1-(1,1-(difluoromethyl)-2-fluoroethyl) substituted derivatives by Remuzon, P, Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J P, Kiechel, J R, Ledoussal, B, Kessler, R E, Fung-Tomc, J

“…A series of novel N-1-(mono-, -(di- and -(trifluoro-tert-butyl)quinolones and -naphthyridines has been prepared. Structure-activity relationship (SAR) studies…”
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Fluoronaphthyridines and -quinolones as antibacterial agents. III, Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluorethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives by REMUZON, P, BOUZARD, D, DI CESARE, P, ESSIZ, M, JACQUET, J. P, KIECHEL, J. R, LEDOUSSAL, B, KESSLER, R. E, FUNG-TOMC, J

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