Search Results - "Ledesma, Maria D."

New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy by Schuchman, Edward H, Ledesma, Maria D, Simonaro, Calogera M

“…Over the past three decades the lysosomal storage diseases have served as model for rare disease treatment development. While these efforts have led to…”
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Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease by Pascua-Maestro, Raquel, Corraliza-Gomez, Miriam, Fadrique-Rojo, Cristian, Ledesma, Maria D., Schuchman, Edward H., Sanchez, Diego, Ganfornina, Maria D.

“…Lysosomal Storage Diseases (LSD) are genetic diseases causing systemic and nervous system dysfunction. The glia-derived lipid binding protein Apolipoprotein D…”
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Pharmacological reversion of sphingomyelin‐induced dendritic spine anomalies in a Niemann Pick disease type A mouse model by Arroyo, Ana I, Camoletto, Paola G, Morando, Laura, Sassoe‐Pognetto, Marco, Giustetto, Maurizio, Van Veldhoven, Paul P, Schuchman, Edward H, Ledesma, Maria D

“…Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary…”
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Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation by Bulloj, Ayelén, Leal, María C, Surace, Ezequiel I, Zhang, Xue, Xu, Huaxi, Ledesma, Maria D, Castaño, Eduardo M, Morelli, Laura

“…Abstract Background Insulin degrading enzyme (IDE) is implicated in the regulation of amyloid β (Aβ) steady-state levels in the brain, and its deficient…”
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Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke by Hernández-Jiménez, Macarena, Martínez-López, Diego, Gabandé-Rodríguez, Enrique, Martín-Segura, Adrian, Lizasoain, Ignacio, Ledesma, María D, Dotti, Carlos G, Moro, María A

“…BACKGROUND AND PURPOSE—3β-Hydroxysteroid-Δ24 reductase (DHCR24) or selective alzheimer disease indicator 1 (seladin-1), an enzyme of cholesterol biosynthetic…”
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Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice by Kuehnle, Katrin, Ledesma, Maria D, Kalvodova, Lucie, Smith, Alicia E, Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M, Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L, Nitsch, Roger M, Mohajeri, M Hasan

“…Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain…”
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Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice by Kuehnle, Katrin, Ledesma, Maria D., Kalvodova, Lucie, Smith, Alicia E., Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M., Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L., Nitsch, Roger M., Mohajeri, M. Hasan

“…The online version of the original article can be found under doi: 10.1007/s11064-008-9893-4…”
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RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice by Kuehnle, Katrin, Ledesma, Maria D., Kalvodova, Lucie, Smith, Alicia E., Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M., Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L., Nitsch, Roger M., Mohajeri, M. Hasan

“…Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain…”
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P1-121: Seladin-1 expression affects APP processing in a cholesterol dependent manner by Kuehnle, Katrin, Crameri, Arames, Lutjohann, Dieter, Dotti, Carlos G., Nitsch, Roger M., Ledesma, Maria D., Mohajeri, Hasan M.

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Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation by Bulloj, Ayelén, Leal, María C, Surace, Ezequiel I, Zhang, Xue, Xu, Huaxi, Ledesma, Maria D, Castaño, Eduardo M, Morelli, Laura

“…Insulin degrading enzyme (IDE) is implicated in the regulation of amyloid beta (Abeta) steady-state levels in the brain, and its deficient expression and/or…”
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Effect of Elevated Pulmonary Vascular Resistance on Outcomes After Percutaneous Mitral Valvuloplasty by Cruz-Gonzalez, Ignacio, MD, PhD, Semigram, Marc J., MD, Inglessis-Azuaje, Ignacio, MD, Sanchez-Ledesma, Maria, MD, Martin-Moreiras, Javier, MD, Jneid, Hani, MD, Rengifo-Moreno, Pablo, MD, Cubeddu, Roberto J., MD, Maree, Andrew O., MD, Sanchez, Pedro L., MD, PhD, Palacios, Igor F., MD

“…Patients with mitral stenosis with severe pulmonary hypertension constitute a high-risk subset for surgical commissurotomy or valve replacement. The aim of the…”
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Predicting Success and Long-Term Outcomes of Percutaneous Mitral Valvuloplasty: A Multifactorial Score by Cruz-Gonzalez, Ignacio, MD, PhD, Sanchez-Ledesma, Maria, MD, Sanchez, Pedro L., MD, PhD, Martin-Moreiras, Javier, MD, Jneid, Hani, MD, Rengifo-Moreno, Pablo, MD, Inglessis-Azuaje, Ignacio, MD, Maree, Andrew O., MD, Palacios, Igor F., MD

“…Abstract Background Percutaneous mitral valvuloplasty (PMV) success depends on appropriate patient selection. A multifactorial score derived from clinical,…”
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Dephosphorylation of tau protein from Alzheimer's disease patients by Szücs, K, Ledesma, M D, Dombrádi, V, Gergely, P, Avila, J, Friedrich, P

“…Tau protein-prepared post-mortem from brains of Alzheimer's disease patients was treated with protein phosphatase 1 catalytic subunit, 2A catalytic subunit,…”
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Impact of concomitant aortic regurgitation on percutaneous mitral valvuloplasty: Immediate results, short-term, and long-term outcome by Sanchez-Ledesma, Maria, MD, Cruz-Gonzalez, Ignacio, MD, PhD, Sanchez, Pedro L., MD, PhD, Martin-Moreiras, Javier, MD, Jneid, Hani, MD, Rengifo-Moreno, Pablo, MD, Cubeddu, Roberto J., MD, Inglessis, Ignacio, MD, Maree, Andrew O., MD, Palacios, Igor F., MD

“…Background The aim of the study is to examine the effect of concomitant aortic regurgitation (AR) on percutaneous mitral valvuloplasty (PMV) procedural…”
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Impact of Pre- and Postprocedural Mitral Regurgitation on Outcomes After Percutaneous Mitral Valvuloplasty for Mitral Stenosis by Jneid, Hani, MD, Cruz-Gonzalez, Ignacio, MD, Sanchez-Ledesma, María, MD, Maree, Andrew O., MD, Cubeddu, Roberto J., MD, Leon, Milton L., MD, Rengifo-Moreno, Pablo, MD, Otero, Juan Pal, MD, Inglessis, Ignacio, MD, Sanchez, Pedro L., MD, Palacios, Igor F., MD

“…Percutaneous mitral valvuloplasty (PMV) is an effective therapy in patients with significant mitral stenosis. Few studies have examined the effect of mitral…”
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