Search Results - "Lederer, JA"

The immunologic response to injury by Mannick, John A, Rodrick, Mary L, Lederer, James A

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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis by Rao, Deepak A., Gurish, Michael F., Marshall, Jennifer L., Slowikowski, Kamil, Fonseka, Chamith Y., Liu, Yanyan, Donlin, Laura T., Henderson, Lauren A., Wei, Kevin, Mizoguchi, Fumitaka, Teslovich, Nikola C., Weinblatt, Michael E., Massarotti, Elena M., Coblyn, Jonathan S., Helfgott, Simon M., Lee, Yvonne C., Todd, Derrick J., Bykerk, Vivian P., Goodman, Susan M., Pernis, Alessandra B., Ivashkiv, Lionel B., Karlson, Elizabeth W., Nigrovic, Peter A., Filer, Andrew, Buckley, Christopher D., Lederer, James A., Raychaudhuri, Soumya, Brenner, Michael B.

“…The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues…”
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Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance by Naeem, Aishath, Utro, Filippo, Wang, Qing, Cha, Justin, Vihinen, Mauno, Martindale, Stephen, Zhou, Yinglu, Ren, Yue, Tyekucheva, Svitlana, Kim, Annette S., Fernandes, Stacey M., Saksena, Gordon, Rhrissorrakrai, Kahn, Levovitz, Chaya, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Davids, Matthew S., Lederer, James A., Zain, Rula, Smith, C. I. Edvard, Leshchiner, Ignaty, Parida, Laxmi, Getz, Gad, Brown, Jennifer R.

“…•BCR signaling is inhibited by pirtobrutinib in vitro and in vivo regardless of BTK C481S mutation but is reactivated in vivo at progression.•BTK mutations at…”
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CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury by Murphy, Thomas J, Choileain, Niamh Ni, Zang, Yan, Mannick, John A, Lederer, James A

“…Major injury initiates a systemic inflammatory response that can be detrimental to the host. We have recently reported that burn injury primes innate immune…”
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Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity by Paterson, Hugh M, Murphy, Thomas J, Purcell, Elizabeth J, Shelley, Odhran, Kriynovich, Sara J, Lien, Egil, Mannick, John A, Lederer, James A

“…Severe injury causes a dramatic host response that disrupts immune homeostasis and predisposes the injured host to opportunistic infections. Because Toll-like…”
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Enhanced Regulatory T Cell Activity Is an Element of the Host Response to Injury by Choileain, Niamh Ni, MacConmara, Malcolm, Zang, Yan, Murphy, Thomas J, Mannick, John A, Lederer, James A

“…CD4+CD25+ regulatory T cells (Tregs) play a critical role in suppressing the development of autoimmune disease, in controlling potentially harmful inflammatory…”
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Injury, sepsis, and the regulation of Toll-like receptor responses by Murphy, Thomas J., Paterson, Hugh M., Mannick, John A., Lederer, James A.

“…Although we tend to think that the immune system has evolved to protect the host from invading pathogens and to discriminate between self and nonself, there…”
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Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury by SHELLEY, Odhran, MURPHY, Thomas, PATERSON, Hugh, MANNICK, John A, LEDERER, James A

“…Substantial clinical and laboratory research has revealed that major injury causes abnormalities in both the innate and adaptive immune systems. However, the…”
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Enhanced TLR4 reactivity following injury is mediated by increased p38 activation by Maung, Adrian A., Fujimi, Satoshi, Miller, Marissa L., MacConmara, Malcolm P., Mannick, John A., Lederer, James A.

“…Severe injury primes the innate‐immune system for increased Toll‐like receptor 4 (TLR4)‐induced proinflammatory cytokine production by macrophages. In this…”
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The effects of injury on the adaptive immune response by Lederer, J A, Rodrick, M L, Mannick, J A

“…For more than thirty years it has been apparent that serious injury in humans and experimental animals is associated with a decrease in immune functions…”
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Linking the “two-hit” response following injury to enhanced TLR4 reactivity by Murphy, Thomas J., Paterson, Hugh M., Kriynovich, Sara, Zang, Yan, Kurt‐Jones, Evelyn A., Mannick, John A., Lederer, James A.

“…Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, “second hit”,…”
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Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection by O'Sullivan, S T, Lederer, J A, Horgan, A F, Chin, D H, Mannick, J A, Rodrick, M L

“…Patients with serious traumatic injury and major burns and an animal model of burn injury were studied to determine the effect of injury on the production of…”
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Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection by Lyons, A, Kelly, J L, Rodrick, M L, Mannick, J A, Lederer, J A

“…The purpose of this study was to compare the production of interleukin-10 (IL-10) by peripheral blood mononuclear cells (PBMC) from injured patients and…”
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Does nitric oxide control the counter-inflammatory response in endotoxic shock? by Lederer, James A

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B cells by MacConmara, Malcolm, Lederer, James A

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Murine dendritic cell antigen-presenting cell function is not altered by burn injury by Fujimi, Satoshi, Lapchak, Peter H., Zang, Yan, MacConmara, Malcolm P., Maung, Adrian A., Delisle, Adam J., Mannick, John A., Lederer, James A.

“…Severe injury disrupts normal immune regulation causing a transient hyperinflammatory reaction and suppressed adaptive immune function. This report addresses…”
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Burn Injury Promotes Antigen-Driven Th2-Type Responses In Vivo by Guo, Zhijun, Kavanagh, Eamon, Zang, Yan, Dolan, Sinead M, Kriynovich, Sara J, Mannick, John A, Lederer, James A

“…Severe injury induces detrimental changes in immune function, often leaving the host highly susceptible to developing life-threatening opportunistic…”
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Burn injury induces an early activation response by lymph node CD4+ T cells by PURCELL, Elizabeth M, DOLAN, Sinead M, KRIYNOVICH, Sara, MANNICK, John A, LEDERER, James A

“…Several reports have shown that burn injury primes the immune system for an early and vigorous proinflammatory CD4 T cell response, suggesting that injury…”
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Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection by GÖEBEL, A, KAVANAGH, E, LYONS, A, SAPOROSCHETZ, I. B, SOBERG, C, LEDERER, J. A, MANNICK, J. A, RODRICK, M. L

“…To assess at serial intervals the production of interleukin-12 (IL-12) by monocytes/macrophages from the peripheral blood of injured patients and control…”
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Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients by Murphy, Thomas, Paterson, Hugh, Rogers, Selwyn, Mannick, John A, Lederer, James A

“…To determine the percentages of major T lymphocyte subsets in the circulating peripheral blood mononuclear cell population in patients with major traumatic…”
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