Search Results - "Ledder, O"

Exogenous interleukin‐2 can rescue in‐vitro T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation by Shamriz, O., Simon, A. J., Lev, A., Megged, O., Ledder, O., Picard, E., Joseph, L., Molho-Pessach, V., Tal, Y., Millman, P., Slae, M., Somech, R., Toker, O., Berger, M.

“…Summary Capping protein regulator and myosin 1 linker 2 (CARMIL2) deficiency is characterized by impaired T cell activation, which is attributed to defective…”
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Eosinophilic esophagitis in children with esophageal atresia by Dhaliwal, J., Tobias, V., Sugo, E., Varjavandi, V., Lemberg, D., Day, A., Bohane, T., Ledder, O., Jiwane, A., Adams, S., Henry, G., Dilley, A., Shi, E., Krishnan, U.

“…Summaryy Eosinophilic esophagitis (EoE) has only rarely been reported in esophageal atresia (EA) patients. A retrospective case analysis of all EA patients…”
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Recurrence of primary sclerosing cholangitis after liver transplantation in children: data from the Pediatric PSC Consortium by Bazerbachi, F, Furuya, K.N, Abdou, R, Alqoaer, K, Amin, M, Amir, A, Auth, M, Broderick, A, Chan, A, Cotter, J, Doan, S, El-Matary, W, El-Youssef, M, Ferrari, F, Gottrand, M, Gottrand, F, Gupta, N, Homan, M, Jensen, M.K, Kamath, B.M, Kim, K.M, Kolho, K.-L, Konidari, A, Koot, B, Iorio, R, Ledder, O, Mack, C, Martinez, M, Miloh, T, Mohan, P, O’Cathain, N, Papadopoulou, A, Ricciuto, A, Sathya, P, Shteyer, E, Tanaka, A, Varier, R, Valentino, P.L, Venkat, V, Vitola, B, Vos, M, Vratislav, S, Woynarowski, M, Yap, J, Deneau, M.R

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P616 Fatigue in pediatric inflammatory bowel diseases – systematic review and rates in a prospective cohort by Focht, G, Turner, S, Carmon, N, Lev-Tzion, R, Orlanski-Meyer, E, Ledder, O, Yogev, D, Assa, A, Turner, D

“…Abstract Background Studies in adults suggest that fatigue is amongst the most commonly reported symptoms, reaching ~50% of patients, often even while the…”
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P1224 Predicting response to nutritional therapy in newly diagnosed children with Crohn’s Disease (CD) using multi-omics approach by Azulay, A, Aharoni Frutkoff, Y, Shimhlash, Y, Borenstein, E, Reshef, L, Plotkin, L, Focht, G, Maslov, T, Orlanski-Meyer, E, Lev-Tzion, R, Ledder, O, Yogev, D, Assa, A, Turner, D

“…Abstract Background Background. One third of children with Crohn's disease (CD) will fail treatment with exclusive enteral nutrition (EEN) but predictors of…”
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P244 The first step to IBD prevention exploring rate of pre-clinical inflammation in subset of asymptomatic subjects at risk of IBD: screening stage of the PIONIR trial by Kenigsberg, S, Turpin, W, Lee, S H, Ledder, O, Shimhlash, Y, Griffiths, A, Huynh, H Q, El-Matary, W, Otley, A, Avni-Biron, I, Jacobson, K, Panaccione, R, Bitton, A, Croitoru, K, Turner, D

“…Abstract Background With the increasing prevalence of inflammatory bowel diseases (IBD) globally, it is necessary to start focusing efforts on prevention of…”
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DOP65 Development and validation of the TUMMY-UC, a patient-reported outcome in pediatric Ulcerative Colitis: A multicenter prospective study by Turner, D, Marcovitch, L, Focht, G, Carmon, N, Tersigni, C, Ledder, O, Lev Tzion, R, Frost, K, Church, P C, Baldassano, R, Otley, A, Kappelman, M, Griffiths, A

“…Abstract Background In developing a patient-reported outcome (PRO) for pediatric ulcerative colitis (UC) with guidance from FDA and EMA, 8 items were…”
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P635 Risankizumab - real world Israeli data in severe refractory IBD patients by Bar-Gil Shitrit, A, Gil, Y, Israeli, E, Koslowsky, B, Mazuz, B, Israel, I, Goldenberg, R, Ben-Bassat, O, Weisbrud, A, Ledder, O, Zinger, A, Ben Horin, S, Goldin, E, Lahat, A

“…Abstract Background The landscape of inflammatory bowel disease (IBD) treatment is rapidly expanding with the development of new therapeutic options…”
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DOP61 Ethnic disparities in the management of Inflammatory Bowel Disease in Israel and impact on outcomes by Boaz, E, Ledder, O, Dagan, A, Lujan, R, Koslowsky, B, Friss, C, Greenfeld, S, Kariv, R, Loewenberg Weisband, Y, Lederman, N, Matz, E, Dotan, I, Yellinek, S, Turner, D

“…Abstract Background In this nationwide study, we aimed to explore health services utilization, medical management, and disease outcomes of inflammatory bowel…”
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P383 Chronic Recurrent Multifocal Osteomyelitis associated with Paediatric Inflammatory Bowel disease: A Multi-Center Retrospective Study from the Paediatric IBD Porto Group of ESPGHAN by Matar, M, Cebecauerova, D, Kolho, K L, Scarallo, L, Hussey, S, Yerushalmy-Feler, A, Pujol-Muncunill, G, Rolandsdotter, H, Distante, M, Granot, M, Olbjørn, C, Zetterström, C K, Velasco Rodríguez-Belvís, M, de Laffolie, J, Ledder, O, Van Biervliet, S, Navas-López, V M, Van Limbergen, J, Konidar, A, Shamir, R, Shouval, D S

“…Abstract Background Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a rare, autoinflammatory bone disorder. CRMO was linked with inflammatory bowel…”
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P609 Impact of accessibility of medical care and socioeconomic class on outcomes of IBD – a nationwide population study by Ledder, O, Harel, S, Orlanski-Meyer, E, Yogev, D, Loewenberg Weisband, Y, Greenfeld, S, Kariv, R, Lederman, N, Matz, E, Schwartz, D, Focht, G, Dotan, I, Turner, D

“…Abstract Background Despite ongoing improvements in Inflammatory Bowel Disease (IBD) therapeutics, timely access to quality medical care likely impacts patient…”
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P628 Tofacitinib in pediatric ulcerative colitis: a retrospective multi-center experience from the Paediatric IBD Porto group of ESPGHAN by Ledder, O, Dubinsky, M, Dolinger, M, Fatima, A, Suskind, D, Scarlett, J, Röeser, D, Shouval, D, Meyer, G, Molle Rios, Z, Pujol, G, Lozano, A, Kolho, K L, Rohani, P, Hussey, S, de Mejj, T, Ayers, T, Navas López, V M, Turner, D, Tzivinikos, C, Stein, R, Savla, , S

“…Abstract Background Tofacitinib, a Janus kinase (JAK) inhibitor, has recently been approved for treatment of moderate to severe active ulcerative colitis (UC)…”
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DOP50 Recommencement of Inflammatory Bowel Disease medications following colectomy for Ulcerative Colitis by Ledder, O, Lujan, R, Orlanski-Meyer, E, Friss, C, Loewenberg Weisband, Y, Greenfeld, S, Kariv, R, Lederman, N, Matz, E, Focht, G, Yanai, H, Ollech, Y, Dotan, I, Turner, D

“…Abstract Background Total colectomy (TC) is often considered a curative procedure for patients with chronic refractory ulcerative colitis (UC) or acute severe…”
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P170 Diagnostic criteria for IBD subtype classification: a multi-centre validation cohort by Sonnino, M, Matar, M, Assa, A, Lev Zion, R, Shteyer, E, Griffiths, A, Turner, D, Ledder, O

“…Abstract Background IBD-unclassified (IBD-U) is a diagnosis on the spectrum between Crohn's disease (CD) and ulcerative colitis (UC) with very low agreement…”
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P280 Prediction factors for low bone mineral density in children with Crohn’s disease by Ronel, N, Guz-Mark, A, Assa, A, Lev Zion, R, Shteyer, E, Strich, D, Turner, D, Ledder, O

“…Abstract Background Since bone mass is almost exclusively accrued during childhood, early recognition and treatment of osteopenia is paramount in paediatric…”
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P370 Endoscopic balloon dilatation in paediatric stricturing Crohn’s disease: A retrospective collaborative study of the paediatric IBD Porto group of ESPGHAN by Ledder, O, Viala, J, Urlep, D, Serban, D, De Ridder, L, Martinelli, M, Romano, C, Oliva, S, Sharma, S, Thomson, M, Turner, D

“…Abstract Background Endoscopic balloon dilatation (EBD) is an effective management strategy in stricturing Crohn’s disease (CD). While adult studies showed a…”
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OP05 Outcome of induction therapy with vedolizumab in children: Results from the prospective, multi-centre VEDOKIDS study by Shavit, Z, Stein, R, Aloi, M, Ledder, O, Focht, G, Urlep, D, Hyams, J, Broide, E, Vais, B, Levine, J, Shouval, D, Matar, M, Assa, A, Rosh, J, Hussey, S, Markowitz, J, Yerushalmy-Feler, A, Miele, E, Shaoul, R, Russell, R K, Turner, D

“…Abstract Background Limited data are available on the use of Vedolizumab (VDZ) in paediatric Crohn’s Disease (CD) and Ulcerative Colitis (UC). We evaluated the…”
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P150 Identification of features associated with poor outcomes in pediatric patients with ulcerative proctitis: A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN by Tal-Shifman, N, Tzivinikos, C, Gasparetto, M, Serban, D E, Zifman, E, Hojsak, I, Ledder, O, Yerushalmy Feler, A, Rolandsdotter, H, Aloi, M, Bramuzzo, M, Buderus, S, Lionetti, P, Norsa, L, Norden, C, Urlep, D, Romano, C, Shaoul, R, Martinez-Vinson, C, Karoliny, A, Veereman, G, Kang, B, Vlčková, E, Alvisi, P, Kori, M, Tavares, M, Weiss, B, Hussey, S, Essen Qamhawi, M, Palomino Pérez, L M, Henderson, P, Parmar, R, Miele, E, Firas Rinawi, F, Lonzano-Ruf, A, Zamvar, V, Kolho, K L, Shouval, D

“…Abstract Background Ulcerative proctitis (UP) is an uncommon presentation in paediatric patients with ulcerative colitis, accounting for <10% of cases. Here we…”
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Clinical Features and Natural History of Paediatric Patients with Ulcerative Proctitis: A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN by Tal, Noa, Tzivinikos, Christos, Gasparetto, Marco, Serban, Daniela E, Zifman, Eyal, Hojsak, Iva, Ledder, Oren, Yerushalmy Feler, Anat, Rolandsdotter, Helena, Aloi, Marina, Bramuzzo, Matteo, Buderus, Stephan, Lionetti, Paolo, Norsa, Lorenzo, Norden, Christoph, Urlep, Darja, Romano, Claudio, Shaoul, Ron, Martinez-Vinson, Christine, Karoliny, Anna, De Greef, Elisabeth, Kang, Ben, VIčková, Eva, Alvisi, Patrizia, Kori, Michal, Tavares, Marta, Weiss, Batia, Hussey, Seamus, Qamhawi, Maria E, Palomino Pérez, Laura M, Henderson, Paul, Parmar, Raj, Miele, Erasmo, Rinawi, Firas, Lozano-Ruf, Ana, Zamvar, Veena, Kolho, Kaija-Leena, Shouval, Dror S

“…Abstract Background and Aims Ulcerative proctitis [UP] is an uncommon presentation in paediatric patients with ulcerative colitis. We aimed to characterize the…”
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OP16 Characterization of the Clinical Features and Outcomes of Paediatric Patients with Isolated Colonic Crohn’s Disease: A Multi-center Study from the Porto Group of ESPGHAN by Berger, T, Miin Lee, H, Ramasamy Padmanaban, L, Wine, E, Yerushalmi, A, Hojsak, I, Bronski, J, Serban, D, Yogev, D, Ledder, O, Lionetti, P, Scarrallo, L, Gasparetto, M, Croft, N, Miele, E, Staiano, A, Meredith, J, Aloi, M, Alvisi, P, Urlep, D, Weiss, B, Knudsen, M, Matar, M, Manuel Navas-López, V, Romano, C, Dipasquale, V, Norsa, L, Kolho, K L, Shamir, R, Shouval, D

“…Abstract Background Isolated colonic (L2) Crohn’s disease (CD) in adults is thought to have unique clinical and genetic features compared with ileal (L1) CD…”
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