Search Results - "Ledbetter, A. D."

Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats by Bass, V., Gordon, C.J., Jarema, K.A., MacPhail, R.C., Cascio, W.E., Phillips, P.M., Ledbetter, A.D., Schladweiler, M.C., Andrews, D., Miller, D., Doerfler, D.L., Kodavanti, U.P.

“…Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin…”
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Acute Pulmonary Toxicity of Particulate Matter Filter Extracts in Rats: Coherence with Epidemiologic Studies in Utah Valley Residents by Dye, Janice A., Lehmann, James R., McGee, John K., Winsett, Darrell W., Ledbetter, Allen D., Everitt, Jeffrey I., Ghio, Andrew J., Costa, Daniel L.

“…Epidemiologic reports by C.A. Pope III et. al. demonstrated that in the Utah Valley, closure of an open-hearth steel mill over the winter of 1987 was…”
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The Spontaneously Hypertensive Rat as a Model of Human Cardiovascular Disease: Evidence of Exacerbated Cardiopulmonary Injury and Oxidative Stress from Inhaled Emission Particulate Matter by Kodavanti, Urmila P., Schladweiler, Mette C., Ledbetter, Allen D., Watkinson, William P., Campen, Matthew J., Winsett, Darrell W., Richards, Judy R., Crissman, Kay M., Hatch, Gary E., Costa, Daniel L.

“…Cardiovascular disease is considered a probable risk factor of particulate matter (PM)-related mortality and morbidity. It was hypothesized that rats with…”
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Systemic Translocation of Particulate Matter–Associated Metals Following a Single Intratracheal Instillation in Rats by Wallenborn, J. Grace, McGee, John K., Schladweiler, Mette C., Ledbetter, Allen D., Kodavanti, Urmila P.

“…Respirable ambient particulate matter (PM) exposure has been associated with an increased risk of cardiovascular disease. Direct translocation of PM-associated…”
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Effect of high-fructose and high-fat diets on pulmonary sensitivity, motor activity, and body composition of brown Norway rats exposed to ozone by Gordon, C. J., Phillips, P. M., Johnstone, A. F. M., Beasley, T. E., Ledbetter, A. D., Schladweiler, M. C., Snow, S. J., Kodavanti, U. P.

“…Diet-induced obesity has been suggested to lead to increased susceptibility to air pollutants such as ozone (O 3 ); however, there is little experimental…”
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Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity by Gordon, C. J., Johnstone, A. F., Aydin, C., Phillips, P. M., MacPhail, R. C., Kodavanti, U. P., Ledbetter, A. D., Jarema, K. A.

“…Abstract Setting exposure standards for environmental pollutants may consider the aged as a susceptible population but the few published studies assessing…”
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Effects of Instilled Combustion-Derived Particles in Spontaneously Hypertensive Rats. Part I: Cardiovascular Responses by Wichers, L. B., Nolan, J. P., Winsett, D. W., Ledbetter, A. D., Kodavanti, U. P., Schladweiler, M. C. J., Costa, D. L., Watkinson, W. P.

“…Epidemiological studies have reported statistically significant associations between the levels of ambient particulate matter (PM) and the incidence of…”
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Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function by Gordon, C. J., Jarema, K. A., Lehmann, J. R., Ledbetter, A. D., Schladweiler, M. C., Schmid, J. E., Ward, W. O., Kodavanti, U. P., Nyska, A., MacPhail, R. C.

“…Ozone (O 3 ) is a pervasive air pollutant that produces pulmonary and cardiovascular dysfunction and possible neurological dysfunction. Young and old…”
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Effects of Instilled Combustion-Derived Particles in Spontaneously Hypertensive Rats. Part II: Pulmonary Responses by Wichers, L. B., Nolan, J. P., Winsett, D. W., Ledbetter, A. D., Kodavanti, U. P., Schladweiler, M. C. J., Costa, D. L., Watkinson, W. P.

“…A consistent association between exposure to high concentrations of ambient particulate matter (PM) and excess cardiopulmonary-related morbidity and mortality…”
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LUNG INJURY FROM INTRATRACHEAL AND INHALATION EXPOSURES TO RESIDUAL OIL FLY ASH IN A RAT MODEL OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION by Kodavanti, U P, Jackson, M C, Ledbetter, A D, Richards, J R, Gardner, S Y, Watkinson, W P, Campen, M J, Costa, D L

“…A rat model of monocrotaline (MCT)-induced pulmonary injury/hypertension has been recently used in particulate matter (PM) health effects studies, however,…”
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Societal savings by “fast tracking” lower acuity patients in an urban pediatric emergency department by Simon, Harold K, Ledbetter, Debra A, Wright, Jean

“…To evaluate the cost-effectiveness of a “fast track” system for diverting lower acuity patients away from the pediatric emergency department (ED), 4,060…”
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The Spontaneously Hypertensive Rat: An Experimental Model of Sulfur Dioxide–Induced Airways Disease by Kodavanti, Urmila P., Schladweiler, Mette C., Ledbetter, Allen D., Ortuno, Roselia Villalobos, Suffia, Marie, Evansky, Paul, Richards, Judy H., Jaskot, Richard H., Thomas, Ronald, Karoly, Edward, Huang, Yuh-Chin T., Costa, Daniel L., Gilmour, Peter S., Pinkerton, Kent E.

“…Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction, inflammation, and mucus hypersecretion, features that are common in…”
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C103 OUTDOOR AIR POLLUTION: EPIDEMIOLOGY AND MECHANISMS: Adrenergic And Steroid Hormone Modulation Of Ozone-Induced Pulmonary Injury And Inflammation by Henriquez, A R, Snow, S J, Schladweiler, M C, Ledbetter, A D, Miller, C N, McGee, M, Williams, W, Richards, J E, Kodavanti, U P

“…[...]we hypothesized that stress hormones receptor agonists will rescue ADREX phenotype restoring sensitivity to ozone-induced lung injury and inflammation in…”
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Residual oil fly ash inhalation in guinea pigs : Influence of absorbate and glutathione depletion by NORWOOD, Joel JR, LEDBETTER, Alan D, DOERFLER, Donald L, HATCH, Gary E

“…Inhaled urban particulate matter (PM) often contains metals that appear to contribute to its toxicity. These particles first make contact with a thin layer of…”
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A49 AIR POLLUTION: CARDIOVASCULAR AND PULMONARY EFFECTS: Ozone-Induced Metabolic Impairment Is Attenuated In Adrenalectomized Wistar Kyoto Rats by Miller, D B, Bass, V L, Andrews, D, Richards, J E, Snowe, S J, Schladweiler, M J, Ledbetter, A D, Kodavanti, U P

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A49 AIR POLLUTION: CARDIOVASCULAR AND PULMONARY EFFECTS: The Role Of Underlying Type 2 Diabetes Mellitus And Obesity In Ozone-Induced Pulmonary Injury And Metabolic Impairment by Snow, S J, Miller, D B, Bass, V L, Schladweiler, M C, Ledbetter, A D, Richards, J E, Andrews, D, Gordon, C J, Kodavanti, U P

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A49 AIR POLLUTION: CARDIOVASCULAR AND PULMONARY EFFECTS: Influence Of High Carbohydrate Versus High Fat Diet In Ozone Induced Pulmonary Injury And Systemic Metabolic Impairment In A Brown Norway (bn) Rat Model Of Healthy Aging by Kodavanti, U P, Bass, V L, Schladweiler, M C, Gordon, C J, Jarema, K A, Phillips, P, Ledbetter, A D, Miller, D B, Snow, S, Richards, J E

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Neurotrophin Mediation of Allergic Airways Responses to Inhaled Diesel Particles in Mice by Farraj, Aimen K., Haykal-Coates, Najwa, Ledbetter, Allen D., Evansky, Paul A., Gavett, Stephen H.

“…Neurotrophins, including nerve growth factor (NGF), partially mediate many features of allergic airways disease including airway hyperresponsiveness. Diesel…”
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Comparative Pulmonary Toxicological Assessment of Oil Combustion Particles Following Inhalation or Instillation Exposure by Costa, Daniel L., Lehmann, James R., Winsett, Darrell, Richards, Judy, Ledbetter, Allen D., Dreher, Kevin L.

“…Controversy persists regarding the validity of intratracheal instillation (IT) of particulate matter (PM) as a surrogate for inhalation exposure (IH) in…”
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The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats by Kodavanti, Urmila P., Schladweiler, Mette C., Gilmour, Peter S., J. Grace Wallenborn, Bhaskar S. Mandavilli, Ledbetter, Allen D., Christiani, David C., Runge, Marschall S., Edward D. Karoly, Costa, Daniel L., Peddada, Shyamal, Richard Jaskot, Richards, Judy H., Thomas, Ronald, Madamanchi, Nageswara R., Nyska, Abraham

“…Background: Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is…”
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