Search Results - "Lecureur, V"
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Alterations of intracellular pH homeostasis in apoptosis: origins and roles
Published in Cell death and differentiation (01-09-2004)“…Intracellular pH (pHi) has an important role in the maintenance of normal cell function, and hence this parameter has to be tightly controlled within a narrow…”
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Toward a better understanding of the etiology of systemic autoimmune diseases : should a systemic disease still be defined as a "diffuse inflammatory disease of unknown origin" in 2021? Example of crystalline silica exposure
Published in La revue de medecine interne (01-04-2021)Get full text
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Drug‐induced granulomatosis: is dupilumab the new kid on the block?
Published in Journal of the European Academy of Dermatology and Venereology (01-07-2020)“…Dupilumab is an IgG4 antibody directed toward IL-4 and IL-13, two major effectors of the Th2 immunity response. It was originally developed for severe and/or…”
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Vers une meilleure compréhension de l’étiologie des maladies auto-immunes systémiques : une maladie systémique doit-elle toujours être définie comme une « maladie inflammatoire diffuse d’origine inconnue » en 2021 ? Exemple de l’exposition à la silice cristalline
Published in La revue de medecine interne (01-04-2021)Get full text
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Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells
Published in Toxicology letters (30-10-2011)“…► 1-Nitropyrene increases apoptosis and lipid accumulation in hepatoma cells. ► 1-NP modifies cholesterol and fatty acids content. ► 1-NP alters the expression…”
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WS17.3 Alteration of human macrophage functions in cystic fibrosis
Published in Journal of cystic fibrosis (01-06-2012)Get full text
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Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells
Published in Biochemical pharmacology (11-05-1995)“…Rifampicin, a semi-synthetic antibiotic used in the treatment of tuberculosis and belonging to the chemical class of rifamycins, was examined for its effect on…”
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Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats
Published in Environmental pollution (1987) (01-04-2018)“…The contribution of diesel exhaust to atmospheric pollution is a major concern for public health, especially in terms of occurrence of lung cancers. The…”
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Vers une meilleure compréhension de l’étiologie des maladies auto-immunes systémiques : une maladie systémique doit-elle toujours être définie comme une « maladie inflammatoire diffuse d’origine inconnue » en 2021 ? Exemple de l’exposition à la silice cristalline
Published in La revue de medecine interne (2021)Get full text
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Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
Published in Toxicology letters (15-03-2008)“…Benzo(a)pyrene (BP) is an environmental contaminant known to favor airway inflammation likely through up-regulation of pro-inflammatory cytokines. The present…”
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Altération des capacités d’efferocytose des macrophages dérivés de monocytes différenciés par CXCL4 et implications dans la sclérodermie systémique
Published in La revue de medecine interne (01-06-2022)“…La sclérodermie systémique (SSc) est une maladie auto-immune caractérisée par l’existence d’anticorps antinucléaires. Leur production peut être liée à un excès…”
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L’amélioration de la fibrose pulmonaire et cutanée dans le modèle murin de bléomycine SSC-ILD par le ruxolitinib n’est pas liée à la capacité d’efferocytose des macrophages
Published in La revue de medecine interne (01-06-2022)“…La sclérodermie systémique (SSc) est caractérisée par la production d’anticorps antinucléaires (ANA) qui pourraient être liés à un excès de cellules…”
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Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450
Published in The Journal of biological chemistry (19-10-2001)“…Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP). BSEP/SPGP expression varies dramatically among human livers. The potency and…”
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Impact thérapeutique des cellules stromales mésenchymateuses adipocytaires sur les sous-populations myéloïdes dans des modèles murins de sclérodermie
Published in La revue de medecine interne (01-06-2023)“…La sclérodermie systémique (SSc) est une maladie auto-immune rare, caractérisée par des manifestations fibrosantes notamment cutanées et pulmonaires. L’arsenal…”
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NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons
Published in Cardiovascular research (01-05-2009)“…Aims Aryl hydrocarbons (AHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BP), are environmental contaminants promoting the…”
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Induction of IL-11 by formaldehyde in human bronchial epithelial cells via MAPK and CREB
Published in Toxicology letters (01-08-2011)Get full text
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La silice cristalline altère les capacités d’efferocytose des macrophages murins et humains : un mécanisme physiopathologique participant à expliquer l’auto-immunité systémique induite par cet aéro-contaminant
Published in La revue de medecine interne (01-12-2019)“…L’inhalation de silice cristalline (SiO2) est un facteur reconnu de survenue de maladies auto-immunes systémiques, et en particulier de connectivites telles…”
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Inhibition of human mesenchymal stem cell-derived adipogenesis by the environmental contaminant benzo(a)pyrene
Published in Toxicology in vitro (01-09-2009)“…Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are environmental contaminants exerting various toxic effects. PAHs have notably been found…”
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Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells
Published in Toxicology letters (30-10-2011)“…1-Nitropyrene (1-NP) is a nitro-polycyclic aromatic hydrocarbon (nitro-PAH) present in diesel exhaust and bound to particular matter in urban air. We show that…”
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