Search Results - "Lectka, Thomas"

Photocatalyzed Benzylic Fluorination: Shedding “Light” on the Involvement of Electron Transfer by Bloom, Steven, McCann, Michael, Lectka, Thomas

“…The photocatalyzed oxidation of benzylic compounds by 1,2,4,5-tetracyanobenzene (TCB) in the presence of Selectfluor provides a synthetically efficient route…”
Get full text

A photocatalyzed aliphatic fluorination by Bloom, Steven, Knippel, James Levi, Lectka, Thomas

“…We disclose a new approach to the catalysis of alkane fluorination employing ultraviolet light and a photosensitizer, 1,2,4,5-tetracyanobenzene (TCB). The…”
Get full text

Aminofluorination of Cyclopropanes: A Multifold Approach through a Common, Catalytically Generated Intermediate by Pitts, Cody Ross, Ling, Bill, Snyder, Joshua A, Bragg, Arthur E, Lectka, Thomas

“…We have discovered a highly regioselective aminofluorination of cyclopropanes. Remarkably, four unique sets of conditionstwo photochemical, two purely…”
Get full text

Fluorine in a C−F Bond as the Key to Cage Formation by Holl, Maxwell Gargiulo, Pitts, Cody Ross, Lectka, Thomas

“…Cage molecules have long been employed to trap reactive or transient species, as their rigid nature allows them to enforce situations that otherwise would not…”
Get full text

Fluorine: A Very Special Element and Its Very Special Impacts on Chemistry by Dehnen, Stefanie, Schafer, Laurel L, Lectka, Thomas, Togni, Antonio

Get full text

A Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination by Bloom, Steven, Pitts, Cody Ross, Miller, David Curtin, Haselton, Nathan, Holl, Maxwell Gargiulo, Urheim, Ellen, Lectka, Thomas

“…A group effort: Reported is the title reaction using a polycomponent catalytic system involving commercially available Selectfluor, a putative radical…”
Get full text

Site-Selective Photochemical Fluorination of Ketals: Unanticipated Outcomes in Selectivity and Stability by Capilato, Joseph N, Pitts, Cody Ross, Rowshanpour, Rozhin, Dudding, Travis, Lectka, Thomas

“…We report a method for the regioselective photochemical sp3 C–H fluorination of acetonide ketals that presents interesting problems in chemical reactivity. The…”
Get full text

Catalyzed and Promoted Aliphatic Fluorination by Bume, Desta Doro, Harry, Stefan Andrew, Lectka, Thomas, Pitts, Cody Ross

“…In the last six years, the direct functionalization of aliphatic C–H (and C–C) bonds through user-friendly, radical-based fluorination reactions has emerged as…”
Get full text

Spectroscopic Characterization of a [C−F−C]+ Fluoronium Ion in Solution by Pitts, Cody Ross, Holl, Maxwell Gargiulo, Lectka, Thomas

“…We report the first spectroscopic evidence for a [C−F−C]+ fluoronium ion in solution. Extensive NMR studies (19F, 1H, 13C) characterize a symmetric cage‐like…”
Get full text

Catalytic, asymmetric reactions of ketenes and ketene enolates by Paull, Daniel H., Weatherwax, Anthony, Lectka, Thomas

“…[Display omitted]…”
Get full text

Asymmetric Cycloadditions of o-Quinone Methides Employing Chiral Ammonium Fluoride Precatalysts by Alden-Danforth, Ethan, Scerba, Michael T, Lectka, Thomas

“…The catalytic, enantioselective, [4 + 2] cycloaddition reaction of ortho-quinone methides with silyl ketene acetals is described. This mechanistically…”
Get full text

Direct, visible light-sensitized benzylic C H fluorination of peptides using dibenzosuberenone: selectivity for phenylalanine-like residues by Bume, Desta Doro, Pitts, Cody Ross, Jokhai, Rayyan Trebonias, Lectka, Thomas

“…A visible light-sensitized benzylic sp super(3) C--H fluorination protocol using dibenzosuberenone (5 mol %) and Selectfluor super( registered ) is optimized…”
Get full text

Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives by Pitts, Cody Ross, Bume, Desta Doro, Harry, Stefan Andrew, Siegler, Maxime A, Lectka, Thomas

“…In the realm of aliphatic fluorination, the problem of reactivity has been very successfully addressed in recent years. In contrast, the associated problem of…”
Get full text

Tandem C-C Bond Cleavage of ­Cyclopropanols and Oxidative Aromatization by Manganese(IV) Oxide in a Direct C-H to C-C Functionalization of Heteroaromatics by Bume, Desta Doro, Pitts, Cody Ross, Lectka, Thomas

“…We report a direct C–H to C–C bond functionalization of electron‐deficient heteroaromatics enabled by mild C–C bond cleavage of cyclopropanols as a new route…”
Get full text

Triethylborane-Initiated Radical Chain Fluorination: A Synthetic Method Derived from Mechanistic Insight by Pitts, Cody Ross, Ling, Bill, Woltornist, Ryan, Liu, Ran, Lectka, Thomas

“…We offer a mild, metal-free sp3 C–H fluorination alternative using Selectfluor and a substoichiometric amount of triethylboranean established radical…”
Get full text

Sensitized Aliphatic Fluorination Directed by Terpenoidal Enones: A “Visible Light” Approach by Bume, Desta Doro, Harry, Stefan Andrew, Pitts, Cody Ross, Lectka, Thomas

“…In our continued effort to address the challenges of selective sp3 C–H fluorination on complex molecules, we report a sensitized aliphatic fluorination…”
Get full text

Carbonyl-Directed Aliphatic Fluorination: A Special Type of Hydrogen Atom Transfer Beats Out Norrish II by Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N, Pitts, Cody Ross, Joram, Jacob, Peters, Garvin N, Tovar, John D, Smajlagic, Ivor, Siegler, Maxime A, Dudding, Travis, Lectka, Thomas

“…Recently, our group reported that enone and ketone functional groups, upon photoexcitation, can direct site-selective sp3 C–H fluorination in terpenoid…”
Get full text

Fluorine: A Very Special Element and Its Very Special Impacts on Chemistry by Dehnen, Stefanie, Schafer, Laurel L, Lectka, Thomas, Togni, Antonio

Get full text

Evidence for a Symmetrical Fluoronium Ion in Solution by Struble, Mark D., Scerba, Michael T., Siegler, Maxime, Lectka, Thomas

“…Halonium ions, in which formally positively charged halogens (chlorine, bromine, and iodine) are equivalently attached to two carbon atoms through three-center…”
Get full text

Intermolecular Aliphatic C–F···H–C Interaction in the Presence of “Stronger” Hydrogen Bond Acceptors: Crystallographic, Computational, and IR Studies by Pitts, Cody Ross, Siegler, Maxime A, Lectka, Thomas

“…An unprecedented intermolecular aliphatic C–F···H–C interaction was observed in the X-ray crystal structure of a fluorinated triterpenoid. Despite the notion…”
Get full text