Search Results - "Leco, Kevin J"

TIMP-3 deficiency leads to dilated cardiomyopathy by FEDAK, Paul W. M, SMOOKLER, David S, WEISEL, Richard D, LI, Ren-Ke, KHOKHA, Rama, KASSIRI, Zamaneh, OHNO, Nobuhisa, LECO, Kevin J, VERMA, Subodh, MICKLE, Donald A. G, WATSON, Katrina L, HOJILLA, Carlo V, CRUZ, William

“…Despite the mounting clinical burden of heart failure, the biomolecules that control myocardial tissue remodeling are poorly understood. TIMP-3 is an…”
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Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix—Cell signaling during bronchiole branching morphogenesis by Gill, Sean E., Pape, M. Cynthia, Leco, Kevin J.

“…Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs) throughout embryogenesis…”
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A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis by Gill, Sean E, Pape, M Cynthia, Khokha, Rama, Watson, Andrew J, Leco, Kevin J

“…Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs). We have examined the role…”
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Absence of tissue inhibitor of metalloproteinases 3 disrupts alveologenesis in the mouse by Gill, Sean E., Pape, M. Cynthia, Leco, Kevin J.

“…Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs) throughout lung…”
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Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene by Young, David A, Phillips, Blaine W, Lundy, Caroline, Nuttall, Robert K, Hogan, Aileen, Schultz, Gilbert A, Leco, Kevin J, Clark, Ian M, Edwards, Dylan R

“…We have used real-time quantitative reverse transcriptase PCR (TaqMan) to quantify the expression of the four tissue inhibitor of metalloproteinases (Timp)…”
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Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone‐induced tail resorption by Jung, Jae‐Chang, Leco, Kevin J., Edwards, Dylan R., Fini, M. Elizabeth

“…It has been suggested that a family of tissue remodelling enzymes called matrix metalloproteinases (MMPs) play a causal role in the process of tail resorption…”
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LUNG MECHANICS IN THE TIMP3 NULL MOUSE AND ITS RESPONSE TO MECHANICAL VENTILATION by Martin, Erica L., Truscott, Emily A., Bailey, Timothy C., Leco, Kevin J., McCaig, Lynda A., Lewis, James F., Veldhuizen, Ruud A. W.

“…Tissue inhibitor of metalloproteinase-3 (TIMP3) null mice develop emphysema-like airspace enlargement due to an enzymatic imbalance. This study investigates…”
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Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3) by Leco, K J, Waterhouse, P, Sanchez, O H, Gowing, K L, Poole, A R, Wakeham, A, Mak, T W, Khokha, R

“…Tissue inhibitors of metalloproteinases regulate ECM degradation by matrix metalloproteinases (MMPs). We have developed a mouse line deficient for tissue…”
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Accelerated apoptosis in the Timp-3-deficient mammary gland by Fata, J E, Leco, K J, Voura, E B, Yu, H Y, Waterhouse, P, Murphy, G, Moorehead, R A, Khokha, R

“…The proapoptotic proteinase inhibitor TIMP-3 is the only molecule of this family thought to influence cell death. We examined epithelial apoptosis in…”
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Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult by Martin, Erica L, Sheikh, Tanya A, Leco, Kevin J, Lewis, James F, Veldhuizen, Ruud A W

“…Mice deficient in tissue inhibitor of metalloproteinase-3 (TIMP-3) develop an emphysema-like phenotype involving increased pulmonary compliance, tissue…”
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Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development by Fata, Jimmie E., Leco, Kevin J., Moorehead, Roger A., Martin, David C., Khokha, Rama

“…The dynamic process of mammary ductal morphogenesis depends on regulated epithelial proliferation and extracellular matrix (ECM) turnover. Epithelial…”
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Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis by Martin, Erica L, Moyer, Brent Z, Pape, M Cynthia, Starcher, Barry, Leco, Kevin J, Veldhuizen, Ruud A W

“…Matrix metalloproteinases (MMPs) are degradative enzymes, which act to remodel tissue. Their activity is regulated by the tissue inhibitors of…”
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Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia by Martin, Erica L, McCaig, Lynda A, Moyer, Brent Z, Pape, M Cynthia, Leco, Kevin J, Lewis, James F, Veldhuizen, Ruud A W

“…An imbalance in matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) leads to excessive or insufficient tissue breakdown,…”
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Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues by LECO, K. J, KHOKHA, R, PAVLOFF, N, HAWKES, S. P, EDWARDS, D. R

“…We have isolated cDNA clones corresponding to a novel mouse metalloproteinase inhibitor. Five overlapping cDNA clones contain most of the information for a…”
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A protective role for TIMP3 in acute lung injury by Gill, Sean E., Huizar, Isham, Bench, Eli M., Nazarian, Negin, Leco, Kevin J., Khokha, Rama, Parks, Bill C.

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Murine tissue inhibitor of metalloproteinases-4 ( Timp-4): cDNA isolation and expression in adult mouse tissues by Leco, Kevin J., Apte, Suneel S., Taniguchi, Gary T., Hawkes, Susan P., Khokha, Rama, Schultz, Gilbert A., Edwards, Dylan R.

“…We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide…”
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Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts by Edwards, Dylan R., Leco, Kevin J., Beaudry, Paul P., Atadja, Peter W., Veillette, Claude, Riabowol, Karl T.

“…The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point in…”
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Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene by Rennie, P S, Bruchovsky, N, Leco, K J, Sheppard, P C, McQueen, S A, Cheng, H, Snoek, R, Hamel, A, Bock, M E, MacDonald, B S

“…The location and sequence of androgen responsive elements (AREs) in the 5'-flanking DNA of the androgen-regulated rat probasin (PB) gene were determined. The…”
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A null mutation for TissueInhibitor ofMetalloproteinases-3 ( Timp-3) impairs murine bronchiole branching morphogenesis by Gill, Sean E, Pape, M.Cynthia, Khokha, Rama, Watson, Andrew J, Leco, Kevin J

“…Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs). We have examined the role…”
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Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus by Leco, Kevin J., Edwards, Dylan R., Schultz, Gilbert A.

“…Embryo implantation in the mouse is a highly orchestrated process, a key aspect of which is the invasion of trophoblast cells of the blastocyst into the…”
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