Search Results - "Leckey, Claire"

Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia by Arber, Charles, Alatza, Argyro, Leckey, Claire A., Paterson, Ross W., Zetterberg, Henrik, Wray, Selina

“…Induced pluripotent stem cell (iPSC) technology enables the generation of human neurons in vitro, which contain the precise genome of the cell donor, therefore…”
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Neurofilament light chain: defining the analyte by Leckey, Claire A., Zetterberg, Henrik

“…This scientific commentary refers to ‘A map of neurofilament light chain species in brain and cerebrospinal fluid and alterations in Alzheimer’s disease’ by…”
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A Multiplexed Urinary Biomarker Panel Has Potential for Alzheimer’s Disease Diagnosis Using Targeted Proteomics and Machine Learning by Hällqvist, Jenny, Pinto, Rui C, Heywood, Wendy E, Cordey, Jonjo, Foulkes, Alexander J. M, Slattery, Catherine F, Leckey, Claire A, Murphy, Eimear C, Zetterberg, Henrik, Schott, Jonathan M, Mills, Kevin, Paterson, Ross W

“…As disease-modifying therapies are now available for Alzheimer’s disease (AD), accessible, accurate and affordable biomarkers to support diagnosis are urgently…”
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SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases by Paterson, Ross W., Gabelle, Audrey, Lucey, Brendan P., Barthélemy, Nicolas R., Leckey, Claire A., Hirtz, Christophe, Lehmann, Sylvain, Sato, Chihiro, Patterson, Bruce W., West, Tim, Yarasheski, Kevin, Rohrer, Jonathan D., Wildburger, Norelle C., Schott, Jonathan M., Karch, Celeste M., Wray, Selina, Miller, Timothy M., Elbert, Donald L., Zetterberg, Henrik, Fox, Nick C., Bateman, Randall J.

“…Alzheimer disease (AD) is one of several neurodegenerative diseases characterized by dysregulation, misfolding and accumulation of specific proteins in the…”
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice by Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Daniela Ruiz, Eva, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A, Simmons, Camilla, Cash, Diana, Richardson, Jill, Jones, Declan N C, Lovestone, Simon, Gómez-Nicola, Diego, Perry, V Hugh

“…Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted…”
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Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes by Paterson, Ross W, Benjamin, Laura A, Mehta, Puja R, Brown, Rachel L, Athauda, Dilan, Ashton, Nicholas J, Leckey, Claire A, Ziff, Oliver J, Heaney, Judith, Heslegrave, Amanda J, Benedet, Andrea L, Blennow, Kaj, Checkley, Anna M, Houlihan, Catherine F, Mummery, Catherine J, Lunn, Michael P, Manji, Hadi, Zandi, Michael S, Keddie, Stephen, Chou, Michael, Vinayan Changaradil, Deepthi, Solomon, Tom, Keshavan, Ashvini, Barker, Suzanne, Jäger, Hans Rolf, Carletti, Francesco, Simister, Robert, Werring, David J, Spyer, Moira J, Nastouli, Eleni, Gauthier, Serge, Rosa-Neto, Pedro, Zetterberg, Henrik, Schott, Jonathan M

“…Abstract Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage…”
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CSF neurofilament light chain profiling and quantitation in neurological diseases by Leckey, Claire A, Coulton, John B, Giovannucci, Tatiana A, He, Yingxin, Aslanyan, Aram, Laban, Rhiannon, Heslegrave, Amanda, Doykov, Ivan, Ammoscato, Francesca, Chataway, Jeremy, De Angelis, Floriana, Gnanapavan, Sharmilee, Byrne, Lauren M, Schott, Jonathan M, Wild, Edward J, Barthelémy, Nicolas R, Zetterberg, Henrik, Wray, Selina, Bateman, Randall J, Mills, Kevin, Paterson, Ross W

“…Neurofilament light chain is an established marker of neuroaxonal injury that is elevated in CSF and blood across various neurological diseases. It is…”
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Stable Isotope Labeling Kinetics (SILK) tracing of neurofilament light in stem cell‐derived neurons by Giovannucci, Tatiana A., Leckey, Claire A., Bateman, Randall J., Zetterberg, Henrik, Mills, Kevin, Wray, Selina, Paterson, Ross W.

“…Background Neurofilament light polypeptide (NfL) is a basic component of intermediate filaments in neurons that is released from damaged and/or degenerated…”
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Stable Isotope Labelling Kinetics tracing of Neurofilament Light in stem cell‐derived neurons and humans by Giovannucci, Tatiana A., Leckey, Claire A., Coulton, John, Zetterberg, Henrik, Elbert, Donald L, Bateman, Randall J., Mills, Kevin, Wray, Selina, Paterson, Ross W.

“…Background Neurofilament light (NfL) is a neuronal cytoskeletal protein that is released into the extracellular environment from degenerated axons. As such,…”
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Inflammatory biomarkers in Alzheimer's disease plasma by Morgan, Angharad R., Touchard, Samuel, Barkhof, Frederik, Bertram, Lars, Bos, Isabelle, Dobricic, Valerija, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Kettunen, Petronella, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Scheltens, Philip, Soininen, Hikka, Tsolaki, Magda, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, Lovestone, Simon, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Crofts, Anna L., Foster, Andrew C., Kitzbichler, Manfred G., Lynall, Mary-Ellen, Maurice, Christina, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Cavanagh, Jonathan, Deith, Catherine, McColl, Alison, Scouller, Paul, Sutherland, Murray, Khan, Shahid, Murphy, Phil, Patel, Jai, de Boer, Peter, Drevets, Wayne C., Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Cash, Diana, Mondelli, Valeria, Nikkheslat, Naghmeh, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Worrell, Courtney, Plath, Niels, Egebjerg, Jan, Gastambide, Francois, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Jones, Helen, Lovestone, Simon, Mada, Francisca, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Sporn, Jonathan, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Murray, Rosemary, Wlazly, Dominika, Mount, Howard

“…Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there are no…”
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Choroid plexus protein turnover in human choroid plexus organoids recapitulates turnover in humans measured using stable isotope labeling kinetics (SILK) by Giovannucci, Tatiana A., Leckey, Claire A., Moncur, Eleanor, Tariq, Kanza, Thorne, Lewis, Watkins, Laurence, Toma, Ahmed, Fox, Nick C, Bateman, Randall J., Mills, Kevin, Pellegrini, Laura, Paterson, Ross W.

“…Background The choroid plexus secretes protein‐rich cerebrospinal fluid (CSF). CSF turnover is a key mechanism for protein clearance. Neurodegenerative…”
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Investigating changes in the proteostasis capabilities of iPSC‐neurons during development and in FTD using iPSC‐neurons with MAPT mutations by Lines, Georgie, Arber, Charles, Preza, Elisavet, Leckey, Claire Alexandra, Myeku, Natura, Casey, Jackie M., Perkinton, Michael, Wray, Selina

“…Background Mutations in microtubule‐associated protein tau (MAPT) gene are causative of Frontotemporal Dementia (FTD). Many of the features associated with the…”
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Development of a targeted proteomic assay for the quantitation of neurofilament light in cerebrospinal fluid: Correlation with Simoa‐based quantitation across neurodegenerative diseases and centres by Leckey, Claire A., Coulton, John, Barthélemy, Nicolas R., He, Yingxin, Laban, Rhiannon, Heslegrave, Amanda, Giovannucci, Tatiana A., Byrne, Lauren M, Swift, Imogen J, Esteve, Aitana Sogorb, Rohrer, Jonathan D., Schott, Jonathan M, Wild, Edward J, Zetterberg, Henrik, Wray, Selina, Mills, Kevin, Bateman, Randall J., Paterson, Ross W.

“…Background Cerebrospinal fluid (CSF) neurofilament light (NfL) is a dynamic biomarker of neurodegeneration that is used for supporting clinical diagnosis and…”
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Complement biomarkers in Alzheimer's disease by Morgan, Angharad R., O’Hagan, Caroline, Leckey, Claire, Touchard, Samuel, Morgan, B. Paul

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P1‐261: DEVELOPMENT OF A UNIFIED ‐OMIC PREPARATION METHODOLOGY: AN ALTERNATIVE, NON‐IP APPROACH TO TARGETED LC‐MS/MS DETECTION OF SECRETED AMYLOID‐β PEPTIDES IN CEREBROSPINAL FLUID AND IPSC‐DERIVED FAMILIAL ALZHEIMER'S DISEASE MODELS by Leckey, Claire Alexandra, Hällqvist, Jenny, Doykov, Ivan Dimitrov, Mills, Kevin, Wray, Selina, Fox, Nick C., Zetterberg, Henrik, Paterson, Ross W.

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NEUROFILAMENT LIGHT IN ISOPOTENTIAL STEM CELL-DERIVED NEURONS WITH FAMILIAL AD MUTATIONS AS A MARKER OF NEURODEGENERATION by Esteve, Aitana Sogorb, Leckey, Claire Alexandra, Arber, Charles, Toombs, Jamie, Wray, Selina, Heslegrave, Amanda J., De Strooper, Bart, Zetterberg, Henrik

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DEVELOPMENT OF A UNIFIED -OMIC PREPARATION METHODOLOGY: AN ALTERNATIVE, NON-IP APPROACH TO TARGETED LC-MS/MS DETECTION OF SECRETED AMYLOID-β PEPTIDES IN CEREBROSPINAL FLUID AND IPSC-DERIVED FAMILIAL ALZHEIMER’S DISEASE MODELS by Leckey, Claire Alexandra, Hällqvist, Jenny, Doykov, Ivan Dimitrov, Mills, Kevin, Wray, Selina, Fox, Nick C., Zetterberg, Henrik, Paterson, Ross W.

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P2‐244: NEUROFILAMENT LIGHT IN ISOPOTENTIAL STEM CELL‐DERIVED NEURONS WITH FAMILIAL AD MUTATIONS AS A MARKER OF NEURODEGENERATION by Esteve, Aitana Sogorb, Leckey, Claire Alexandra, Arber, Charles, Toombs, Jamie, Wray, Selina, Heslegrave, Amanda J., De Strooper, Bart, Zetterberg, Henrik

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EX-VIVO VALIDATION OF PLASMA PROTEIN FIBRINOGEN GAMMA by Ashton, Nicholas J., Westwood, Sarah, Leckey, Claire, Aarsland, Dag, Hye, Abdul

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Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease by Vicente-Rodríguez, Marta, Mancuso, Renzo, Peris-Yague, Alba, Simmons, Camilla, Gómez-Nicola, Diego, Perry, V Hugh, Turkheimer, Federico, Lovestone, Simon, Parker, Christine A, Cash, Diana

“…Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as…”
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