Search Results - "Lecker, S. H."

Atrogin-1, A Muscle-Specific F-Box Protein Highly Expressed during Muscle Atrophy by Gomes, Marcelo D., Lecker, Stewart H., Jagoe, R. Thomas, Navon, Ami, Goldberg, Alfred L.

“…Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein…”
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Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states by Lecker, S H, Solomon, V, Mitch, W E, Goldberg, A L

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Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway by Kwon, Yong Tae, Xia, Zanxian, Davydov, Ilia V., Lecker, Stewart H., Varshavsky, Alexander

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats by Lecker, S. H., Solomon, V., Price, S. R., Kwon, Y. T., Mitch, W. E., Goldberg, A. L.

“…Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because…”
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Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia by Martinelli, G B, Olivari, D, Re Cecconi, A D, Talamini, L, Ottoboni, L, Lecker, S H, Stretch, C, Baracos, V E, Bathe, O F, Resovi, A, Giavazzi, R, Cervo, L, Piccirillo, R

“…Cancer cachexia is a life-threatening syndrome that affects most patients with advanced cancers and causes severe body weight loss, with rapid depletion of…”
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The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle by Solomon, Vered, Lecker, Stewart H., Goldberg, Alfred L.

“…In skeletal muscle, overall protein degradation involves the ubiquitin-proteasome system. One property of a protein that leads to rapid ubiquitin-dependent…”
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ProOmpA contains secondary and tertiary structure prior to translocation and is shielded from aggregation by association with SecB protein by Lecker, S. H., Driessen, A. J., Wickner, W.

“…Escherichia coli protein export involves cytosolic components termed molecular chaperones which function to stabilize precursors for membrane translocation. It…”
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Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy by Sandri, Marco, Sandri, Claudia, Gilbert, Alex, Skurk, Carsten, Calabria, Elisa, Picard, Anne, Walsh, Kenneth, Schiaffino, Stefano, Lecker, Stewart H, Goldberg, Alfred L

“…Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. In atrophying muscles, the ubiquitin ligase,…”
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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression by Lecker, Stewart H., Jagoe, R. Thomas, Gilbert, Alexander, Gomes, Marcelo, Baracos, Vickie, Bailey, James, Price, S. Russ, Mitch, William E., Goldberg, Alfred L.

“…ABSTRACT Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases including diabetes, cancer, and renal failure. We had…”
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Cobalt-catalyzed one-step assembly of B-ring aromatic steroids from acyclic precursors by Lecker, Stewart H, Nguyen, Nhan H, Vollhardt, K. Peter C

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Ubiquitin–protein ligases in muscle wasting by Cao, Pei Rang, Kim, Hannah J., Lecker, Stewart H.

“…Muscle wasting occurs when rates of protein degradation outstrip rates of protein synthesis. Accelerated rates of protein degradation develop in atrophying…”
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Patterns of gene expression in atrophying skeletal muscles: response to food deprivation by Jagoe, R. Thomas, Lecker, Stewart H., Gomes, Marcelo, Goldberg, Alfred L.

“…During fasting and many systemic diseases, muscle undergoes rapid loss of protein and functional capacity. To define the transcriptional changes triggering…”
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Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways? by Lecker, Stewart H., Goldberg, A. L.

“…PURPOSE OF REVIEW: Studies in a wide variety of animal models of muscle wasting have led to the concept that increased protein breakdown via the…”
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Slowing muscle atrophy: putting the brakes on protein breakdown by Lecker, Stewart H., Goldberg, Alfred L.

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ProOmpA contains secondary and tertiary stucture prior to translocation and is shielded from aggregation by association with SecB protein by LECKER, S. H, DRIESSEN, A. J. M, WICKNER, W

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