Search Results - "Leckband, Deborah"

Protein Adsorption on Grafted Zwitterionic Polymers Depends on Chain Density and Molecular Weight by Ahmed, Syeda Tajin, Leckband, Deborah E.

“…This study demonstrates that protein adsorption on end‐grafted, zwitterionic poly(sulfobetaine) (pSBMA) thin films depends on the grafting density, molecular…”
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Protein Folding Stability and Kinetics in Alginate Hydrogels by Chang, Roger, Gruebele, Martin, Leckband, Deborah E.

“…Proteins are commonly encapsulated in alginate gels for drug delivery and tissue-engineering applications. However, there is limited knowledge of how…”
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Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation by Chang, Roger, Gruebele, Martin, Leckband, Deborah E.

“…Polymers designed to stabilize proteins exploit direct interactions or crowding, but mechanisms underlying increased stability or reduced aggregation are…”
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Forces between mica and end-grafted statistical copolymers of sulfobetaine and oligoethylene glycol in aqueous electrolyte solutions by Ahmed, Syeda Tajin, Leckband, Deborah E.

“…[Display omitted] This study quantified the interfacial forces associated with end-grafted, statistical (AB) co-polymers of sulfobetaine methacrylate (SBMA)…”
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Dynamic Visualization of α-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States by Kim, Tae-Jin, Zheng, Shuai, Sun, Jie, Muhamed, Ismaeel, Wu, Jun, Lei, Lei, Kong, Xinyu, Leckband, Deborah E., Wang, Yingxiao

“…The cytosolic protein α-catenin is a postulated force transducer at cadherin complexes [1]. The demonstration of force activation, identification of consequent…”
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Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers by Barry, Adrienne K, Wang, Ning, Leckband, Deborah E

“…In this study, we present results demonstrating that mechanotransduction by vascular endothelial cadherin (VE-cadherin, also known as CDH5) complexes in…”
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Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation by Niessen, Carien M, Leckband, Deborah, Yap, Alpha S

“…This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis. Tissue physiology is profoundly influenced by the…”
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Ionic strength dependent forces between end-grafted Poly(sulfobetaine) films and mica by Ahmed, Syeda Tajin, Madinya, Jason J., Leckband, Deborah E.

“…[Display omitted] The molecular surface properties of zwitterionic polymer coatings are central to their ultra-low fouling properties and effectiveness as…”
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Mechanotransduction at cadherin-mediated adhesions by Leckband, Deborah E, le Duc, Quint, Wang, Ning, de Rooij, Johan

“…Highlights ► The role of force at cell-to-cell junctions in development and disease. ► Recent advances in quantitative measurements of intercellular tension. ►…”
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Stabilization and Kinetics of an Adsorbed Protein Depends on the Poly(N‑isopropylacrylamide) Grafting Density by Mora-Sierra, Zully, Gopan, Gopika, Chang, Roger, Leckband, Deborah E, Gruebele, Martin

“…The solubility transition at the lower critical solution temperature (LCST, 32 °C) of poly­(N-isopropylacrylamide) (PNIPAM) is widely used as a thermal switch…”
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E-cadherin-mediated force transduction signals regulate global cell mechanics by Muhamed, Ismaeel, Wu, Jun, Sehgal, Poonam, Kong, Xinyu, Tajik, Arash, Wang, Ning, Leckband, Deborah E

“…This report elucidates an E-cadherin-based force-transduction pathway that triggers changes in cell mechanics through a mechanism requiring epidermal growth…”
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Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner by le Duc, Quint, Shi, Quanming, Blonk, Iris, Sonnenberg, Arnoud, Wang, Ning, Leckband, Deborah, de Rooij, Johan

“…Cell surface receptors integrate chemical and mechanical cues to regulate a wide range of biological processes. Integrin complexes are the mechanotransducers…”
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Extracellular matrix regulates force transduction at VE-cadherin junctions by Kong, Xinyu, Kapustka, Adrian, Sullivan, Brendan, Schwarz, Gregory J, Leckband, Deborah E

“…Increased tension on VE-cadherin complexes activates adaptive cell stiffening and local cytoskeletal reinforcement-two key signatures of intercellular…”
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Cadherin cis and trans interactions are mutually cooperative by Thompson, Connor J., Vu, Vinh H., Leckband, Deborah E., Schwartz, Daniel K.

“…Cadherin transmembrane proteins are responsible for intercellular adhesion in all biological tissues and modulate tissue morphogenesis, cell motility, force…”
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Mechanical activation of epidermal growth factor receptor at intercellular adhesions by Leckband, Deborah E., Vu, Vinh H., Zou, Yubo, Sullivan, Brendan G.

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Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions by Ishiyama, Noboru, Sarpal, Ritu, Wood, Megan N., Barrick, Samantha K., Nishikawa, Tadateru, Hayashi, Hanako, Kobb, Anna B., Flozak, Annette S., Yemelyanov, Alex, Fernandez-Gonzalez, Rodrigo, Yonemura, Shigenobu, Leckband, Deborah E., Gottardi, Cara J., Tepass, Ulrich, Ikura, Mitsuhiko

“…α-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton…”
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Protein Adsorption on Poly(N-isopropylacrylamide) Brushes: Dependence on Grafting Density and Chain Collapse by Xue, Changying, Yonet-Tanyeri, Nihan, Brouette, Nicolas, Sferrazza, Michele, Braun, Paul V, Leckband, Deborah E

“…The protein resistance of poly(N-isopropylacrylamide) brushes grafted from silicon wafers was investigated as a function of the chain molecular weight,…”
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Comparative effects of N-cadherin protein and peptide fragments on mesenchymal stem cell mechanotransduction and paracrine function by Qin, Ellen C., Ahmed, Syeda T., Sehgal, Poonam, Vu, Vinh H., Kong, Hyunjoon, Leckband, Deborah E.

“…The recent interest in exploiting cadherin-derived fragments to mimic intercellular adhesion in engineered hybrid biomaterials raises questions about which…”
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Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity by Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Underhill, Gregory H, Leckband, Deborah E

“…Abstract The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing…”
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A computational study for understanding the impact of p120-catenin on the cis-dimerization of cadherin by Su, Zhaoqian, Vu, Vinh H, Leckband, Deborah E, Wu, Yinghao

“…Abstract A prototype of cross-membrane signal transduction is that extracellular binding of cell surface receptors to their ligands induces intracellular…”
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