Search Results - "Lechner, Matt"

Signatures of copy number alterations in human cancer by Steele, Christopher D., Abbasi, Ammal, Islam, S. M. Ashiqul, Bowes, Amy L., Khandekar, Azhar, Haase, Kerstin, Hames-Fathi, Shadi, Ajayi, Dolapo, Verfaillie, Annelien, Dhami, Pawan, McLatchie, Alex, Lechner, Matt, Light, Nicholas, Shlien, Adam, Malkin, David, Feber, Andrew, Proszek, Paula, Lesluyes, Tom, Mertens, Fredrik, Flanagan, Adrienne M., Tarabichi, Maxime, Van Loo, Peter, Alexandrov, Ludmil B., Pillay, Nischalan

“…Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle…”
Get full text

Pan-cancer deconvolution of tumour composition using DNA methylation by Chakravarthy, Ankur, Furness, Andrew, Joshi, Kroopa, Ghorani, Ehsan, Ford, Kirsty, Ward, Matthew J., King, Emma V., Lechner, Matt, Marafioti, Teresa, Quezada, Sergio A., Thomas, Gareth J., Feber, Andrew, Fenton, Tim R.

“…The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach…”
Get full text

Deregulation of SYCP2 predicts early stage human papillomavirus‐positive oropharyngeal carcinoma: A prospective whole transcriptome analysis by Masterson, Liam, Sorgeloos, Frederic, Winder, David, Lechner, Matt, Marker, Alison, Malhotra, Shalini, Sudhoff, Holger, Jani, Piyush, Goon, Peter, Sterling, Jane

“…This study was designed to identify significant differences in gene expression profiles of human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal…”
Get full text

Snoring and breathing pauses during sleep: interview survey of a United Kingdom population sample reveals a significant increase in the rates of sleep apnoea and obesity over the last 20 years - data from the UK sleep survey by Lechner, Matt, Breeze, Charles E., Ohayon, Maurice M., Kotecha, Bhik

“…(1) To determine the prevalence of snoring, breathing pauses during sleep and obstructive sleep apnoea syndrome in the United Kingdom (UK) and determine the…”
Get full text

Distorted chemosensory perception and female sex associate with persistent smell and/or taste loss in people with SARS-CoV-2 antibodies: a community based cohort study investigating clinical course and resolution of acute smell and/or taste loss in people with and without SARS-CoV-2 antibodies in London, UK by Makaronidis, Janine, Firman, Chloe, Magee, Cormac G, Mok, Jessica, Balogun, Nyaladzi, Lechner, Matt, Carnemolla, Alisia, Batterham, Rachel L

“…Loss of smell and/or taste are cardinal symptoms of COVID-19. 'Long-COVID', persistence of symptoms, affects around one fifth of people. However, data…”
Get full text

Intratympanic Steroid Use for Sudden Sensorineural Hearing Loss: Current Otolaryngology Practice by Lechner, Matt, Sutton, Liam, Ferguson, Mark, Abbas, Yasmin, Sandhu, Jaswinder, Shaida, Azhar

“…Objective: To investigate the current practice of intratympanic steroid (ITS) injection for sudden sensorineural hearing loss (SSNHL) in the United Kingdom and…”
Get full text

Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis by Basyuni, Shadi, Nugent, Gareth, Ferro, Ashley, Barker, Eleanor, Reddin, Ian, Jones, Oliver, Lechner, Matt, O’Leary, Ben, Jones, Terry, Masterson, Liam, Fenton, Tim, Schache, Andrew

“…This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of…”
Get full text

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance by Chakravarthy, Ankur, Reddin, Ian, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, Rodriguez, Daniela Rothschild, Martinez, Natalia Gonzalez, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S., Skingen, Vilde Eide, Lyng, Heidi, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lechner, Matt, Ellis, Peter J. I., Wass, Mark, Michaelis, Martin, Fiegl, Heidi, Salvesen, Helga, Thomas, Gareth J., Doorbar, John, Chester, Kerry, Feber, Andrew, Fenton, Tim R.

“…Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643…”
Get full text

Universal penalized regression (Elastic-net) model with differentially methylated promoters for oral cancer prediction by Das, Shantanab, Karuri, Saikat, Chakraborty, Joyeeta, Basu, Baidehi, Chandra, Aditi, Aravindan, S, Chakraborty, Anirvan, Paul, Debashis, Ray, Jay Gopal, Lechner, Matt, Beck, Stephan, Teschendorff, E Andrew, Chatterjee, Raghunath

“…DNA methylation showed notable potential to act as a diagnostic marker in many cancers. Many studies proposed DNA methylation biomarker in OSCC detection,…”
Get full text

Association of subjective olfactory dysfunction and 12‐item odor identification testing in ambulatory COVID‐19 patients by Prajapati, Divya P., Shahrvini, Bita, MacDonald, Bridget V., Crawford, Kayva L., Lechner, Matt, DeConde, Adam S., Yan, Carol H.

“…Background Acute loss of smell and taste are well‐recognized symptoms of coronavirus disease 2019 (COVID‐19), yet the correlation between self‐reported and…”
Get full text

Olfactory Nomenclature: An Orchestrated Effort to Clarify Terms and Definitions of Dysosmia, Anosmia, Hyposmia, Normosmia, Hyperosmia, Olfactory Intolerance, Parosmia, and Phantosmia/Olfactory Hallucination by Hernandez, Anna Kristina, Landis, Basile N, Altundag, Aytug, Fjaeldstad, Alexander Wieck, Gane, Simon, Holbrook, Eric H, Huart, Caroline, Konstantinidis, Iordanis, Lechner, Matt, Macchi, Alberto, Portillo Mazal, Patricia, Miwa, Takaki, Philpott, Carl M, Pinto, Jayant M, Poletti, Sophia C, Vodicka, Jan, Welge-Luessen, Antje, Whitcroft, Katherine L, Hummel, Thomas

“…Definitions are essential for effective communication and discourse, particularly in science. They allow the shared understanding of a thought or idea,…”
Get more information

Course of symptoms for loss of sense of smell and taste over time in one thousand forty‐one healthcare workers during the Covid‐19 pandemic: Our experience by Lechner, Matt, Liu, Jacklyn, Counsell, Nicholas, Ta, Ngan Hong, Rocke, John, Anmolsingh, Rajesh, Eynon‐Lewis, Nicholas, Paun, Santdeep, Hopkins, Claire, Khwaja, Sadie, Kumar, B. Nirmal, Jayaraj, Samuel, Lund, Valerie J., Philpott, Carl

Get full text

Letter to the Editor Regarding Comparison of 2 and 4 Intratympanic Steroid Injections in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss by Suzuki et al by Sutton, Liam, McElveen, John T., Brookes, Gerald, Shaida, Azhar, Lechner, Matt

Get full text

Molecular Basis and Rationale for the Use of Targeted Agents and Immunotherapy in Sinonasal Cancers by Esposito, Andrea, Stucchi, Erika, Baronchelli, Maria, Di Mauro, Pierluigi, Ferrari, Marco, Lorini, Luigi, Gurizzan, Cristina, London, Nyall Robert Jr, Hermsen, Mario, Lechner, Matt, Bossi, Paolo

“…Despite the progress of surgery, radiotherapy, and neoadjuvant chemotherapy, the prognosis for advanced sinonasal cancers (SNCs) remains poor. In the era of…”
Get full text

Author Correction: Pan-cancer deconvolution of tumour composition using DNA methylation by Chakravarthy, Ankur, Furness, Andrew, Joshi, Kroopa, Ghorani, Ehsan, Ford, Kirsty, Ward, Matthew J., King, Emma V., Lechner, Matt, Marafioti, Teresa, Quezada, Sergio A., Thomas, Gareth J., Feber, Andrew, Fenton, Tim R.

“…The original version of this Article contained an error in Figure 4. In panel a, the colour code for hot and cold clusters was inadvertently inverted. In the…”
Get full text

Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review by Turri-Zanoni, Mario, Dalfino, Gianluca, Lechner, Matt, Dallan, Iacopo, Battaglia, Paolo, Facco, Carla, Franzi, Francesca, Gravante, Giacomo, Ferrari, Marco, Terzakis, Dimitrios, Jay, Amrita, Forster, Martin D, Ambrosoli, Andrea Luigi, Bignami, Maurizio, Georgalas, Christos, Herman, Philippe, Nicolai, Piero, Lund, Valerie J, Castelnuovo, Paolo

“…Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade cancer that was included from the 4th edition of WHO classification of head and neck tumours. The…”
Get full text

Telemedicine and Telementoring in Rhinology, Otology, and Laryngology: A Scoping Review by Yang, Angela, Kim, Dayoung, Hwang, Peter H., Lechner, Matt

“…Objective Telemedicine and telementoring have had a significant boost across all medical and surgical specialties over the last decade and especially during…”
Get full text

The genomics and epigenetics of olfactory neuroblastoma: A systematic review by Kaur, Raman Preet, Izumchenko, Evgeny, Blakaj, Dukagjin M., Mladkova, Nikol, Lechner, Matt, Beaumont, Thomas L., Floudas, Charalampos S., Gallia, Gary L., London, Nyall R.

“…Background Olfactory neuroblastoma (ONB) or esthesioneuroblastoma (ENB) is a rare malignancy of the nasal cavity believed to arise from the olfactory…”
Get full text

Anosmia and hyposmia in health-care workers with undiagnosed SARS-CoV-2 infection by Lechner, Matt, Counsell, Nicholas, Liu, Jacklyn, Eynon-Lewis, Nicholas, Paun, Santdeep, Lund, Valerie J, Jayaraj, Sam, Philpott, Carl

Get full text

Preoperative and postoperative optimisation of patients undergoing thyroid surgery: a multicentre quality improvement project at Barts Health NHS Trust by Lechner, Matt, Moghul, Gulwish, Chandrasekharan, Deepak, Ashraf, Salman, Emanuel, Oscar, Magos, Tiarnan, Liu, Zi Wei, Crutchlow, Margaret, Kinghorn, Stephen, McDonnell, Gayle, McArdle, Harry, Salem, Amr, Papesch, Mike, Majumdar, Kalpita, Lakhdar, Abdulfattah, Ali, Safina, Ahmed, Jahangir, Alusi, Ghassan, Stimpson, Paul, Waterhouse, Mona, Ghufoor, Khalid

“…Hypocalcaemia following thyroid surgery can occur in up to 38% of patients. With over 7100 thyroid surgeries performed in 2018 in the UK, this is a common…”
Get full text