Search Results - "Lechner, M. C."

Atypical ductal hyperplasia diagnosed at stereotactic breast biopsy: improved reliability with 14-gauge, directional, vacuum-assisted biopsy by Jackman, R J, Burbank, F, Parker, S H, Evans, 3rd, W P, Lechner, M C, Richardson, T R, Tocino, I, Wray, A B

“…To compare histologic findings of atypical ductal hyperplasia (ADH) at 14-gauge, directional, vacuum-assisted breast biopsy (hereafter, vacuum-assisted biopsy)…”
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Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT24 homozygotes in Portuguese patients with colorectal cancer by GIL, J. P, LECHNER, M. C

“…Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population…”
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Nonpalpable breast lesions: correlation of stereotaxic large-core needle biopsy and surgical biopsy results by Elvecrog, E L, Lechner, M C, Nelson, M T

“…One hundred women, each with a single nonpalpable breast lesion evident at mammography, underwent computer-guided sterotaxic 14-gauge needle biopsy followed by…”
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Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study by Smits, K. M., Gaspari, L., Weijenberg, M. P., Dolzan, V., Golka, K., Roemer, H. C., Nedelcheva Kristensen, V., Lechner, M. C., Mehling, G. I., Seidegard, J., Strange, R. C., Taioli, E.

“…Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the…”
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Association of A313 G polymorphism (GSTP1B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease by Vilar, R., Coelho, H., Rodrigues, E., Gama, M. J., Rivera, I., Taioli, E., Lechner, M. C.

“…Genetic predisposition, environmental toxins and aging contribute to Parkinson's disease (PD) multifactorial etiology. Weak environmental neurotoxic factors…”
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Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer by CRISTOVAO, L, LECHNER, M. C, FIDALGO, P, LEITAO, C. N, MIRA, F. C, RUEFF, J

“…Poly(ADP-ribose)polymerase (PARP) has been implicated in DNA repair mechanisms and the associated activity shown to markedly increase after DNA damage in…”
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Population genetics of hyperphenylalaninaemia resulting from phenylalanine hydroxylase deficiency in Portugal by Rivera, I, Leandro, P, Lichter-Konecki, U, Tavares de Almeida, I, Lechner, M C

“…In order to elucidate the molecular basis of phenylketonuria (PKU) in Portugal, a detailed study of the Portuguese mutant phenylalanine hydroxylase (PAH) genes…”
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Cloning and characterization of a novel CYP3A1 allelic variant: analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone by Ribeiro, V, Lechner, M C

“…A clone was isolated from a cDNA library constructed from phenobarbital-treated Wistar rat liver and proven to correspond to the full-length mRNA of a…”
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Stereotactic breast biopsy of nonpalpable lesions: determinants of ductal carcinoma in situ underestimation rates by Jackman, R J, Burbank, F, Parker, S H, Evans, 3rd, W P, Lechner, M C, Richardson, T R, Smid, A A, Borofsky, H B, Lee, C H, Goldstein, H M, Schilling, K J, Wray, A B, Brem, R F, Helbich, T H, Lehrer, D E, Adler, S J

“…To measure the effect of biopsy device, probe size, mammographic lesion type, lesion size, and number of samples obtained per lesion on the ductal carcinoma in…”
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Cerebral hemorrhage and apoE by GARCIA, C, PINHO E MELO, T, ROCHA, L, LECHNER, M. C

“…The epsilon4 allele of apolipoprotein E (apoE) is found more commonly among patients with Alzheimer's disease (AD) than in the normal population. ApoE is…”
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Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid by Wright, M C, Wang, X J, Pimenta, M, Ribeiro, V, Paine, A J, Lechner, M C

“…Metyrapone administration to 21- and 90-day-old male rats causes a transcriptional induction of the hepatic glucocorticoid-inducible CYP3A1 gene within an hour…”
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Developmental changes in the constitutive and inducible expression of cytochrome p450 3a2 by Wright, Matthew C, Edwards, Robert J, Pimenta, Michel, Ribeiro, Vera, Ratra, Gurpreet S, Lechner, Maria Celeste, Paine, Alan J

“…Using a CYP3A2-specific oligonucleotide and an antipeptide antibody raised against the C terminus of CYP3A2 (VINGA) it is demonstrated that metyrapone…”
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Understanding how indoor environmental classroom conditions influence academic performance in higher education by Brink, Henk W., Lechner, Stefan C.M., Loomans, Marcel G.L.C., Mobach, Mark P., Kort, Helianthe S.M.

“…Purpose This study aims to qualitatively examine the relationship between the indoor environmental quality (IEQ), lecturers’ and students’ perceived internal…”
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The experience of patients in an outpatient infusion facility: a qualitative study by Zijlstra, Emma, Hagedoorn, Mariët, Lechner, Stefan C.M, van der Schans, Cees P, Mobach, Mark P

“…Purpose As hospitals are now being designed with an increasing number of single rooms or cubicles, the individual preference of patients with respect to social…”
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Age of onset in patients with Alzheimer’s disease with different apoE genotypes by COUTO, FREDERICO SIMÕES DO, DE MENDONÇA, ALEXANDRE, GARCIA, CARLOS, ROCHA, LUÍSA, LECHNER, MARIA CELESTE

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Glycerol Increases the Yield and Activity of Human Phenylalanine Hydroxylase Mutant Enzymes Produced in a Prokaryotic Expression System by Leandro, Paula, Lechner, Maria Celeste, Tavares de Almeida, Isabel, Konecki, David

“…Chemical chaperones are low molecular weight compounds known to stabilize proteins in vitro. Recently it was shown that, in transfected cells, these molecules…”
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The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases by Chasserot-Golaz, S, Ribeiro, V, Genot, G, Lechner, M C, Beck, G

“…Microsomal preparations from adult male rat liver actively oxidized RU38486 into the 11 beta-monodemethylated, 11 beta-didemethylated and 17 alpha-hydroxylated…”
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Critical amino-terminal segments in insertion of rat liver cytochrome P450 3A1 into the endoplasmic reticulum membrane by Van den Broek, P J, Barroso, M, Lechner, M C

“…An in vitro transcription-translation assay was used to study the membrane topology of rat liver cytochrome P450 3A1. N-terminus deletion mutants were…”
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The V388M Mutation Results in a Kinetic Variant Form of Phenylalanine Hydroxylase by Leandro, Paula, Rivera, Isabel, Lechner, Maria Celeste, de Almeida, Isabel Tavares, Konecki, David

“…The molecular mechanism underlying the metabolic defect in phenylketonuria (PKU) patients carrying the V388M missense mutation of the phenylalanine hydroxylase…”
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ADP-ribosylation of nuclear proteins is increased by phenobarbital: Identification of the ADP-ribosylated histone fractions in rat liver nuclei by Bràz, Judite, Celeste Lechner, Maria

“…Changes in the ADP-ribosylation of total proteins and purified histones of rat liver nuclei after phenobarbital treatment (80 mg kg , 24 h) have been studied…”
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