Search Results - "Lechleiter, James D."

Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage by Sayre, Naomi L, Sifuentes, Mikaela, Holstein, Deborah, Cheng, Sheue-yann, Zhu, Xuguang, Lechleiter, James D

“…We previously demonstrated that stimulation of astrocyte mitochondrial ATP production via P2Y1 receptor agonists was neuroprotective after cerebral ischemic…”
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Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K+ currents in neurons by Vigil, Fabio A, Bozdemir, Eda, Bugay, Vladislav, Chun, Sang H, Hobbs, MaryAnn, Sanchez, Isamar, Hastings, Shayne D, Veraza, Rafael J, Holstein, Deborah M, Sprague, Shane M, M Carver, Chase, Cavazos, Jose E, Brenner, Robert, Lechleiter, James D, Shapiro, Mark S

“…Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5…”
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Germline mutations in TMEM127 confer susceptibility to pheochromocytoma by King, Elizabeth E, Yao, Li, Lechleiter, James D, Aronin, Neil, Opocher, Giuseppe, Boaretto, Francesca, Chocron, E Sandra, Lenci, Romina E, Stiles, Charles, Buddavarapu, Kalyan, Toledo, Sergio P A, Dahia, Patricia L M, Schiavi, Francesca, Qin, Yuejuan, Sass, Meghan, Aguiar, Ricardo C T, Toledo, Rodrigo A

“…Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary. However, the molecular basis of the majority of…”
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P2Y1R-Initiated, IP3R-Dependent Stimulation of Astrocyte Mitochondrial Metabolism Reduces and Partially Reverses Ischemic Neuronal Damage in Mouse by Zheng, Wei, Watts, Lora Talley, Holstein, Deborah M, Wewer, Jimmy, Lechleiter, James D

“…Glia-based neuroprotection strategies are emerging as promising new avenues to treat brain damage. We previously reported that activation of the glial-specific…”
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Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways by Zhou, Lijun, Deepa, Sathyaseelan S., Etzler, Julie C., Ryu, Jiyoon, Mao, Xuming, Fang, Qichen, Liu, Dianna D., Torres, Jesus M., Jia, Weiping, Lechleiter, James D., Liu, Feng, Dong, Lily Q.

“…The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated protein kinase (AMPK) activation in…”
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Calcineurin β protects brain after injury by activating the unfolded protein response by Chen, Yanan, Holstein, Deborah M, Aime, Sofia, Bollo, Mariana, Lechleiter, James D

“…Abstract The Ca 2 + -dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is…”
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Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs by Bollo, Mariana, Paredes, R Madelaine, Holstein, Deborah, Zheleznova, Nadezhda, Camacho, Patricia, Lechleiter, James D

“…The accumulation of misfolded proteins within the endoplasmic reticulum (ER) triggers a cellular process known as the Unfolded Protein Response (UPR). One of…”
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Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease by Chen, Qiang, Aguirre, Luis, Liang, Guoming, Zhao, Huanhuan, Dong, Tao, Borrego, Felix, de Rojas, Itziar, Hu, Qichan, Reyes, Christopher, Su, Ling-Yan, Zhang, Bao, Lechleiter, James D, Göring, Harald H H, De Jager, Philip L, Kleinman, Joel E, Hyde, Thomas M, Li, Pan P, Ruiz, Agustín, Weinberger, Daniel R, Seshadri, Sudha, Ma, Liang

“…The APOE gene is the strongest genetic risk factor for late-onset Alzheimer's Disease (LOAD). However, the gene regulatory mechanisms at this locus remain…”
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Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria by Zheng, Wei, Watts, Lora Talley, Holstein, Deborah M, Prajapati, Suresh I, Keller, Charles, Grass, Eileen H, Walter, Christi A, Lechleiter, James D

“…Treatments to improve the neurological outcome of edema and cerebral ischemic stroke are severely limited. Here, we present the first in vivo single cell…”
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Modeling the Neuroprotective Role of Enhanced Astrocyte Mitochondrial Metabolism during Stroke by Diekman, Casey O., Fall, Christopher P., Lechleiter, James D., Terman, David

“…A mathematical model that integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and…”
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Measurement of Intracellular Calcium by Takahashi, Akiyuki, Camacho, Patricia, Lechleiter, James D, Herman, Brian

“…Departments of Cellular and Structural Biology and of Physiology, and Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health…”
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Luminal Ca2+ depletion during the unfolded protein response in Xenopus oocytes: Cause and consequence by Paredes, R. Madelaine, Bollo, Mariana, Holstein, Deborah, Lechleiter, James D

“…Abstract The endoplasmic reticulum (ER) is a Ca2+ storing organelle that plays a critical role in the synthesis, folding and post-translational modifications…”
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Mitochondrial Targeted Cyclophilin D Protects Cells from Cell Death by Peptidyl Prolyl Isomerization by Lin, Da-Ting, Lechleiter, James D

“…Cyclophilin D (CyPD) is thought to sensitize opening of the mitochondrial permeability transition pore (mPTP) based on the findings that cyclosporin A (CsA), a…”
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The Trifunctional Protein Mediates Thyroid Hormone Receptor-Dependent Stimulation of Mitochondria Metabolism by Chocron, E. Sandra, Sayre, Naomi L, Holstein, Deborah, Saelim, Nuttawut, Ibdah, Jamal A, Dong, Lily Q, Zhu, Xuguang, Cheng, Sheue-Yann, Lechleiter, James D

“…We previously demonstrated that the thyroid hormone, T3, acutely stimulates mitochondrial metabolism in a thyroid hormone receptor (TR)-dependent manner. T3…”
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Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke by Fisher, Elizabeth S, Chen, Yanan, Sifuentes, Mikaela M, Stubblefield, Jeremy J, Lozano, Damian, Holstein, Deborah M, Ren, JingMei, Davenport, Matthew, DeRosa, Nicholas, Chen, Tsung-Pei, Nickel, Gerard, Liston, Theodore E, Lechleiter, James D

“…Acute ischemic stroke (AIS) is the second leading cause of death globally. No Food and Drug Administration (FDA) approved therapies exist that target…”
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Chemical calcium indicators by Paredes, R. Madelaine, Etzler, Julie C., Watts, Lora Talley, Zheng, Wei, Lechleiter, James D.

“…Our understanding of the underlying mechanisms of Ca2+ signaling as well as our appreciation for its ubiquitous role in cellular processes has been rapidly…”
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Lack of Interactions Between Alteplase/Tenecteplase and the Adenosine A1R/A3R Agonist AST-004 by Liston, Theodore E, Holstein, Deborah, Solt, Derek, Lozano, Damian, Korinek, William S, Lechleiter, James D

“…AST-004, a small molecule agonist of the adenosine A1 and A3 receptors, is a potential cerebroprotectant for patients with acute stroke and is currently in…”
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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment by Van Skike, Candice E, Jahrling, Jordan B, Olson, Angela B, Sayre, Naomi L, Hussong, Stacy A, Ungvari, Zoltan, Lechleiter, James D, Galvan, Veronica

“…An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-derived factors into the brain parenchyma. The BBB is damaged in…”
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PI 3‐kinase regulation of dopamine uptake by Carvelli, Lucia, Morón, José A., Kahlig, Kristopher M., Ferrer, Jasmine V., Sen, Namita, Lechleiter, James D., Leeb‐Lundberg, L. M. Fredrik, Merrill, Gerald, Lafer, Eileen M., Ballou, Lisa M., Shippenberg, Toni S., Javitch, Jonathan A., Lin, Richard Z., Galli, Aurelio

“…The magnitude and duration of dopamine (DA) signaling is defined by the amount of vesicular release, DA receptor sensitivity, and the efficiency of DA…”
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Differential Modulation of SERCA2 Isoforms by Calreticulin by John, Linu M., Lechleiter, James D., Camacho, Patricia

“…In Xenopus laevis oocytes, overexpression of calreticulin suppresses inositol 1,4,5-trisphosphate-induced Ca2+oscillations in a manner consistent with…”
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