Search Results - "Lechleider, Robert J."

Circulating tumor cells: application as a biomarker for molecular characterization and predictor of survival in an all-comer solid tumor phase I clinical study by Bao, Haifeng, Burke, Patricia A, Huang, Jiaqi, Chen, Xiaoru, Brohawn, Philip Z, Yao, Yihong, Lechleider, Robert J, Sikorski, Robert S, Buzoianu, Manuela, Zhang, Jianliang, Shi, Xiaoqing, Richman, Laura K, Lavallee, Theresa M

“…Clinical development of cancer drugs has a low success rate. Prognostic and predictive biomarkers using minimally invasive approaches hold promise for…”
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Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant by LECHLEIDER, Robert J, ARLEN, Philip M, TSANG, Kwong-Yok, STEINBERG, Seth M, YOKOKAWA, Junko, CEREDA, Vittore, CAMPHAUSEN, Kevin, SCHLOM, Jeffrey, DAHUT, William L, GULLEY, James L

“…Purpose: We have previously reported on the safety and immunologic response of a poxvirus-based vaccine encoding prostate-specific antigen (PSA) used in…”
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Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels by Roman, Beth L, Pham, Van N, Lawson, Nathan D, Kulik, Magdalena, Childs, Sarah, Lekven, Arne C, Garrity, Deborah M, Moon, Randall T, Fishman, Mark C, Lechleider, Robert J, Weinstein, Brant M

“…The zebrafish mutant violet beauregarde ( vbg ) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells…”
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Ixabepilone in Combination with Capecitabine and as Monotherapy for Treatment of Advanced Breast Cancer Refractory to Previous Chemotherapies by Lechleider, Robert J, Kaminskas, Edvardas, Jiang, Xiaoping, Aziz, Robeena, Bullock, Julie, Kasliwal, Ravindra, Harapanhalli, Ravi, Pope, Sarah, Sridhara, Rajeshwari, Leighton, John, Booth, Brian, Dagher, Ramzi, Justice, Robert, Pazdur, Richard

“…Purpose: To describe the considerations leading to marketing approval of ixabepilone in combination with capecitabine and as monotherapy for the treatment of…”
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Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner by VERRECCHIA, Franck, VINDEVOGHEL, Laurence, LECHLEIDER, Robert J, UITTO, Jouni, ROBERTS, Anita B, MAUVIEL, Alain

“…Smad proteins transduce signals from TGF-beta receptors and regulate transcription of target genes either directly or in combination with other…”
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SNIP1 Is a Candidate Modifier of the Transcriptional Activity of c-Myc on E Box-Dependent Target Genes by Fujii, Makiko, Lyakh, Lyudmila A., Bracken, Cameron P., Fukuoka, Junya, Hayakawa, Morisada, Tsukiyama, Tadasuke, Soll, Steven J., Harris, Melissa, Rocha, Sonia, Roche, Kevin C., Tominaga, Shin-ichi, Jen, Jin, Perkins, Neil D., Lechleider, Robert J., Roberts, Anita B.

“…Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and…”
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Thrombotic Microangiopathy with Targeted Cancer Agents by BLAKE-HASKINS, John A, LECHLEIDER, Robert J, KREITMAN, Robert J

“…Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are clinically similar disorders characterized by microvascular thrombosis,…”
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Transforming growth factor-β receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate? by Sharifi, Nima, Lechleider, Robert J, Farrar, William L

“…AbstractThe transforming growth factor-β (TGF-β) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but…”
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SMAD3/4-Dependent Transcriptional Activation of the Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor β by Vindevoghel, Laurence, Lechleider, Robert J., Kon, Atsushi, De Caestecker, Mark P., Uitto, Jouni, Roberts, Anita B., Mauviel, Alain

“…The human type VII collagen gene (COL7A1) recently has been identified as an immediate-early response gene for transforming growth factor β (TGF-β )/SMAD…”
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Transforming Growth Factor-β–Induced Differentiation of Smooth Muscle From a Neural Crest Stem Cell Line by Chen, Shiyou, Lechleider, Robert J

“…During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in…”
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Transcriptional Activating Activity of Smad4: Roles of SMAD Hetero-Oligomerization and Enhancement by an Associating Transactivator by Shioda, Toshi, Lechleider, Robert J., Dunwoodie, Sally L., Li, Huchun, Yahata, Tetsuro, De Caestecker, Mark P., Fenner, Martin H., Roberts, Anita B., Isselbacher, Kurt J.

“…Smad4 plays a pivotal role in signal transduction of the transforming growth factor β superfamily cytokines by mediating transcriptional activation of target…”
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Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression by FRONTELO, Pilar, LEADER, Jennifer E, YOO, Naomi, POTOCKI, Alex C, CRAWFORD, Michelle, KULIK, Magdalena, LECHLEIDER, Robert J

“…Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands to regulate the expression of target genes. In order to…”
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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β by Yang, Xiao, Letterio, John J., Lechleider, Robert J., Chen, Lin, Hayman, Russ, Gu, Hua, Roberts, Anita B., Deng, Chuxia

“…SMAD3 is one of the intracellular mediators that transduces signals from transforming growth factor‐β (TGF‐β) and activin receptors. We show that SMAD3 mutant…”
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RhoA Modulates Smad Signaling during Transforming Growth Factor-β-induced Smooth Muscle Differentiation by Chen, Shiyou, Crawford, Michelle, Day, Regina M., Briones, Victorino R., Leader, Jennifer E., Jose, Pedro A., Lechleider, Robert J.

“…We recently reported that transforming growth factor (TGF)-β induced the neural crest stem cell line Monc-1 to differentiate into a spindle-like contractile…”
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Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-β by Briones, Victorino R., Chen, Shiyou, Riegel, Anna Tate, Lechleider, Robert J.

“…Transforming growth factor-β (TGF-β) is the prototypical member of a family of growth factors that play important roles in normal development and human…”
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A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif by Roberts, Anita B, Larisch, Sarit, Yi, Youngsuk, Lotan, Rona, Kerner, Hedviga, Eimerl, Sarah, Tony Parks, W, Gottfried, Yossi, Birkey Reffey, Stephanie, de Caestecker, Mark P, Danielpour, David, Book-Melamed, Naomi, Timberg, Rina, Duckett, Colin S, Lechleider, Robert J, Steller, Hermann, Orly, Joseph, Kim, Seong-Jin

“…Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling…”
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Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases by de Caestecker, M P, Parks, W T, Frank, C J, Castagnino, P, Bottaro, D P, Roberts, A B, Lechleider, R J

“…SMAD proteins mediate signals from receptor serine-threonine kinases (RSKs) of the TGF-beta superfamily. We demonstrate here that HGF and EGF, which signal…”
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The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors by Wang, Tongwen, Li, Bi-Yu, Danielson, Paul D, Shah, Paresh C, Rockwell, Sybil, Lechleider, Robert J, Martin, Jennifer, Manganaro, Thomas, Donahoe, Patricia K

“…The immunophilin FKBP12 is an evolutionarily conserved abundant protein; however, its physiological roles remain poorly defined. Here we report that FKBP12 is…”
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The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain by de Caestecker, Mark P., Yahata, Tetsuro, Wang, David, Parks, W.Tony, Huang, Shixia, Hill, Caroline S., Shioda, Toshi, Roberts, Anita B., Lechleider, Robert J.

“…Transforming growth factor-β (TGF-β) family members signal through a unique set of intracellular proteins called Smads. Smad4, previously identified as the…”
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The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors by Yahata, Tetsuro, de Caestecker, Mark P., Lechleider, Robert J., Andriole, Stephanie, Roberts, Anita B., Isselbacher, Kurt J., Shioda, Toshi

“…The MSG1 nuclear protein has a strong transcriptional activating activity but does not bind directly to DNA. When cotransfected, MSG1 enhances transcription…”
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