Search Results - "Lebron, J A"

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor by Bjorkman, Pamela J, Bennett, Melanie J, Lebrón, José A

“…HFE is related to major histocompatibility complex (MHC) class I proteins and is mutated in the iron-overload disease hereditary haemochromatosis. HFE binds to…”
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Preparation and characterization of metallomicelles of Ru(II). Cytotoxic activity and use as vector by Lebrón, J.A., Ostos, F.J., López-López, M., Moyá, M.L., Kardell, O., Sánchez, A., Carrasco, C.J., García-Calderón, M., García-Calderón, C.B., Rosado, I.V., López-Cornejo, P.

“…[Display omitted] •Metallomicelles of Ru(II) showed cytotoxic activity and selectivity by some cancer cell lines.•Confocal fluorescence microscopy demonstrated…”
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Binding of DNA by a dinitro-diester calix[4]arene: Denaturation and condensation of DNA by Ostos, F.J., Lebron, J.A., Moyá, M.L., Deasy, M., López-Cornejo, P.

“…•The presence of a functionalized calixarene in calf thymus DNA solutions induces a condensation of the polynucleotide.•The suitable functionalization of the…”
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Cooperative interaction between metallosurfactants, derived from the [Ru(2,2'-bpy)3](2+) complex, and DNA by Lebrón, J A, Ostos, F J, Moyá, M L, López-López, M, Carrasco, C J, López-Cornejo, P

“…With the idea of improving and advancing the design and preparation of new reagents based on cationic surfactants for gene therapy, two luminescent…”
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Adaptation of the WHO guideline for residual DNA in parenteral vaccines produced on continuous cell lines to a limit for oral vaccines by Lebron, J A, Troilol, P J, Pacchione, S, Griffiths, T G, Harper, L B, Mixson, L A, Jackson, B E, Michna, L, Barnum, A B, Denisova, L, Johnson, C N, Maurer, K L, Morgan-Hoffman, S, Niu, Z, Roden, D F, Wang, Z, Wolf, J J, Hamilton, T R, Laux, K M, Soper, K A, Ledwith, B J

“…Although there is a WHO guidance for a limit on residual DNA for parenterally administered vaccines produced on continuous cell lines, there is no…”
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Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor by Lebrón, José A., Bennett, Melanie J., Vaughn, Daniel E., Chirino, Arthur J., Snow, Peter M., Mintier, Gabriel A., Feder, John N., Bjorkman, Pamela J.

“…HFE is an MHC-related protein that is mutated in the iron-overload disease hereditary hemochromatosis. HFE binds to transferrin receptor (TfR) and reduces its…”
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The Hemochromatosis Gene Product Complexes with the Transferrin Receptor and Lowers Its Affinity for Ligand Binding by Feder, John N., Penny, David M., Irrinki, Alivelu, Lee, Vince K., Lebron, Jose A., Watson, Nicole, Tsuchihashi, Zenta, Sigal, Elliott, Bjorkman, Pamela J., Schatzman, Randall C.

“…We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a member of the major…”
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Tumorigenicity assessments of Per.C6 cells and of an Ad5-vectored HIV-1 vaccine produced on this continuous cell line by Ledwith, B J, Lanning, C L, Gumprecht, L A, Anderson, C A, Coleman, J B, Gatto, N T, Balasubramanian, G, Farris, G M, Kemp, R K, Harper, L B, Barnum, A B, Pacchione, S J, Mauer, K L, Troilo, P F J, Brown, E R, Wolf, J J, Lebronl, J A, Lewis, J A, Nichols, W W

“…PER.C6, a cell line derived from human embryonic retinal cells transformed with the Adenovirus Type 5 (Ad5) E1A and E1B genes, is used to produce E1-deleted…”
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The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor by Lebrón, J A, West, Jr, A P, Bjorkman, P J

“…HFE is a class I major histocompatibility complex (MHC)-related protein that is mutated in patients with the iron overload disease hereditary hemochromatosis…”
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Tolerization of adult mice to immunodominant proteins before monoclonal antibody production by Lebrón, José A, Shen, Huazhang, Bjorkman, Pamela J, Ou, Susan

“…Generating monoclonal antibodies (mAbs) against one polypeptide chain of a heterodimeric protein can be difficult when the other chain is more immunogenic. To…”
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The Transferrin Receptor Binding Site on HFE, the Class I MHC-related Protein Mutated in Hereditary Hemochromatosis by Lebrón, José A., Bjorkman, Pamela J.

“…HFE is a class I major histocompatibility complex (MHC)-related protein that is mutated in patients with the iron storage disease hereditary hemochromatosis…”
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Extended repertoire of permissible peptide ligands for HLA‐B2702 by Raghavan, Malini, Lebrón, José A., Johnson, Jennifer L., Bjorkman, Pamela J.

“…Recognition of self peptides bound to the class I major histocompatibility complex molecule HLA‐B27 is thought to trigger proliferation of autoreactive T cells…”
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Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis by Bjorkman, Pamela J, Ramalingam, T. S, West, Anthony P, Lebrón, José A, Nangiana, Jasvinder S, Hogan, Thomas H, Enns, Caroline A

“…HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin receptor (TfR). Here we show that wild-type HFE and TfR localize in…”
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Influence of adding terminal tags on the structural and antimicrobial properties of the peptide caerin 1.1 by Cuesta, A., Vila, M., Molina-Marquez, A., Carbajo, C., Lebron, J.A., López-López, M., López-Cornejo, P., Moyá, M.L., López-Sanmartín, M., López, J.R., Navas, J.I., Vigara, J., León, R.

“…Aquaculture is threatened by severe bacterial and viral outbreaks which can cause massive mortality and limit productivity. Antimicrobial peptides are a…”
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Cooperative interaction between metallosurfactants, derived from the [Ru(2,2′-bpy)3]2+ complex, and DNA by Lebrón, J.A., Ostos, F.J., Moyá, M.L., López-López, M., Carrasco, C.J., López-Cornejo, P.

“…Schematic representation of the condensation and de-condensation processes of DNA. [Display omitted] •The presence of metallosurfactants derived from…”
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