Search Results - "Leblond, Marine M"

Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies by Oster, Paul, Vaillant, Laurie, Riva, Erika, McMillan, Brynn, Begka, Christina, Truntzer, Caroline, Richard, Corentin, Leblond, Marine M, Messaoudene, Meriem, Machremi, Elisavet, Limagne, Emeric, Ghiringhelli, Francois, Routy, Bertrand, Verdeil, Gregory, Velin, Dominique

“…In this study, we determined whether ( ) infection dampens the efficacy of cancer immunotherapies. Using mouse models, we evaluated whether immune checkpoint…”
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M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastoma by Leblond, Marine M, Pérès, Elodie A, Helaine, Charly, Gérault, Aurélie N, Moulin, Damien, Anfray, Clément, Divoux, Didier, Petit, Edwige, Bernaudin, Myriam, Valable, Samuel

“…In some highly inflammatory tumors, such as glioblastoma (GB), macrophages (MΦ) represent the most abundant population of reactive cells. MΦ, initially denoted…”
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Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models by Leblond, Marine M, Gérault, Aurélie N, Corroyer-Dulmont, Aurélien, MacKenzie, Eric T, Petit, Edwige, Bernaudin, Myriam, Valable, Samuel

“…Hypoxia is a common feature of solid tumors, particularly in glioblastoma (GBM), and known to be a poor prognosis factor in GBM patients. The growth of GBM is…”
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Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes by Valable, Samuel, Gérault, Aurélie N., Lambert, Gaëlle, Leblond, Marine M., Anfray, Clément, Toutain, Jérôme, Bordji, Karim, Petit, Edwige, Bernaudin, Myriam, Pérès, Elodie A.

“…Tumor hypoxia is known to limit the efficacy of ionizing radiations, a concept called oxygen enhancement ratio (OER). OER depends on physical factors such as…”
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Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy by Leblond, Marine M., Zdimerova, Hana, Desponds, Emma, Verdeil, Grégory

“…Tumor-associated macrophages (TAMs) are one of the most abundant infiltrating immune cells of solid tumors. Despite their possible dual role, i.e., pro- or…”
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Maf deficiency in T cells dysregulates T reg - T H 17 balance leading to spontaneous colitis by Imbratta, Claire, Leblond, Marine M, Bouzourène, Hanifa, Speiser, Daniel E, Velin, Dominique, Verdeil, Grégory

“…The maintenance of homeostasis in the gut is a major challenge for the immune system. Here we demonstrate that the transcription factor MAF plays a central…”
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c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells by Trabanelli, Sara, Ercolano, Giuseppe, Wyss, Tania, Gomez‐Cadena, Alejandra, Falquet, Maryline, Cropp, Daniela, Imbratta, Claire, Leblond, Marine M, Salvestrini, Valentina, Curti, Antonio, Adotevi, Olivier, Jandus, Camilla, Verdeil, Grégory

“…Group‐2 innate lymphoid cells (ILC2s), which are involved in type 2 inflammatory diseases such as allergy, can exhibit immunological memory, but the basis of…”
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Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion by Tillé, Laure, Cropp, Daniela, Charmoy, Mélanie, Reichenbach, Patrick, Andreatta, Massimo, Wyss, Tania, Bodley, Gabrielle, Crespo, Isaac, Nassiri, Sina, Lourenco, Joao, Leblond, Marine M., Lopez-Rodriguez, Cristina, Speiser, Daniel E., Coukos, George, Irving, Melita, Carmona, Santiago J., Held, Werner, Verdeil, Grégory

“…Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion…”
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Development of Traceable Mouse Models of Advanced and Metastatic Bladder Cancer by Desponds, Emma, Kioseoglou, Konstantina, Zdimerova, Hana, Ongaro, Marco, Verdeil, Grégory, Leblond, Marine M

“…Bladder cancer (BC) is the fourth most common cancer in men, with a poor patient prognosis for advanced disease. The poor survival of patients with…”
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Maf deficiency in T cells dysregulates Treg - TH17 balance leading to spontaneous colitis by Imbratta, Claire, Leblond, Marine M., Bouzourène, Hanifa, Speiser, Daniel E., Velin, Dominique, Verdeil, Grégory

“…The maintenance of homeostasis in the gut is a major challenge for the immune system. Here we demonstrate that the transcription factor MAF plays a central…”
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Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer by Desponds, Emma, Croci, Davide, Wosika, Victoria, Hadadi, Noushin, Fonseca Costa, Sara S, Ciarloni, Laura, Ongaro, Marco, Zdimerova, Hana, Leblond, Marine M, Hosseinian Ehrensberger, Sahar, Romero, Pedro, Verdeil, Grégory

“…Blood-based biomarkers represent ideal candidates for the development of non-invasive immuno-oncology-based assays. However, to date, no blood biomarker has…”
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Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study by Helaine, Charly, Ferré, Aurélie E, Leblond, Marine M, Pérès, Elodie A, Bernaudin, Myriam, Valable, Samuel, Petit, Edwige

“…(1) We wanted to assess the impact of Ang2 in RCT-induced changes in the environment of glioblastoma. (2) The effect of Ang2 overexpression in tumor cells was…”
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Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models by Chakhoyan, Ararat, Corroyer-Dulmont, Aurélien, Leblond, Marine M, Gérault, Aurélie, Toutain, Jérôme, Chazaviel, Laurent, Divoux, Didier, Petit, Edwige, MacKenzie, Eric T, Kauffmann, François, Delcroix, Nicolas, Bernaudin, Myriam, Touzani, Omar, Valable, Samuel

“…The alleviation of hypoxia in glioblastoma with carbogen to improve treatment has met with limited success. Our hypothesis is that the eventual benefits of…”
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Flow cytometry detection and quantification of circulating leukocyte subpopulations in mice after brain irradiation by Coupey, Julie, Leblond, Marine M, Hue, Erika S, Valable, Samuel

“…In the context of high-grade gliomas such as glioblastoma (GBM), the immune part of the tumor microenvironment (TME) is involved in tumor growth and tumor…”
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Abstract 7620: Immuno-transcriptomic profiling of blood and tumor tissue identifies gene signatures associated with immunotherapy response in metastatic bladder cancer by Romero, Pedro J., Desponds, Emma, Croci, Davide, Wosika, Victoria, Hadadi, Noushin, Cost, Sara Fonseca, Ciarloni, Laura, Ongaro, Marco, Zdimerova, Hana, Leblond, Marine M., Hosseinian-Ehrensberger, Sahar, Verdeil, Grégory

“…Abstract Muscle-invasive bladder cancer (MIBC) accounts for 25% of bladder cancer cases. Despite the broader usage of immune checkpoint blockade targeting the…”
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Abstract A30: Hypoxia induces macrophage polarization and re-education towards an M2 phenotype in glioblastoma by Leblond, Marine M., Gérault, Aurélie N., Corroyer-Dulmont, Aurélien, Petit, Edwige, Bernaudin, Myriam, Valable, Samuel

“…Abstract Introduction: Hypoxia, resulting in a decrease in tissue oxygen tension, is a main characteristic of glioblastoma (GBM) and is associated to a poor…”
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Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes by Valable, Samuel, Gerault, AureTie N, Lambert, Gaelle, Leblond, Marine M, Anfray, Clement, Toutain, Jerome, Bordji, Karim, Petit, Edwige, Bernaudin, Myriam, Peres, Elodie A

“…Tumor hypoxia is known to limit the efficacy of ionizing radiations, a concept called oxygen enhancement ratio (OER). OER depends on physical factors such as…”
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