Search Results - "Leblond, Jeanne"

Pharmaceutical Applications of Molecular Tweezers, Clefts and Clips by Mbarek, Amira, Moussa, Ghina, Chain, Jeanne Leblond

“…Synthetic acyclic receptors, composed of two arms connected with a spacer enabling molecular recognition, have been intensively explored in host-guest…”
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Programmable self-regulated molecular buffers for precise sustained drug delivery by Desrosiers, Arnaud, Derbali, Rabeb Mouna, Hassine, Sami, Berdugo, Jérémie, Long, Valérie, Lauzon, Dominic, De Guire, Vincent, Fiset, Céline, DesGroseillers, Luc, Leblond Chain, Jeanne, Vallée-Bélisle, Alexis

“…Unlike artificial nanosystems, biological systems are ideally engineered to respond to their environment. As such, natural molecular buffers ensure precise and…”
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Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method by Berger, Manon, Degey, Manon, Leblond Chain, Jeanne, Maquoi, Erik, Evrard, Brigitte, Lechanteur, Anna, Piel, Géraldine

“…Polyethylene glycol (PEG) is used in Lipid Nanoparticles (LNPs) formulations to confer stealth properties and is traditionally anchored in membranes by a lipid…”
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Poly(N‐methyl‐N‐vinylacetamide): A Strong Alternative to PEG for Lipid‐Based Nanocarriers Delivering siRNA by Berger, Manon, Toussaint, François, Ben Djemaa, Sanaa, Maquoi, Erik, Pendeville, Hélène, Evrard, Brigitte, Jerôme, Christine, Leblond Chain, Jeanne, Lechanteur, Anna, Mottet, Denis, Debuigne, Antoine, Piel, Géraldine

“…Lipid‐based nanocarriers have demonstrated high interest in delivering genetic material, exemplified by the success of Onpattro and COVID‐19 vaccines. While…”
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Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma by Tabatabaei, Seyed Nasrollah, Derbali, Rabeb Mouna, Yang, Chun, Superstein, Rosanne, Hamel, Patrick, Chain, Jeanne Leblond, Hardy, Pierre

“…Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the…”
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Reduction of advanced-glycation end products levels and inhibition of RAGE signaling decreases rat vascular calcification induced by diabetes by Brodeur, Mathieu R, Bouvet, Céline, Bouchard, Sonia, Moreau, Simon, Leblond, Jeanne, Deblois, Denis, Moreau, Pierre

“…Advanced-glycation end products (AGEs) were recently implicated in vascular calcification, through a process mediated by RAGE (receptor for AGEs). Although a…”
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GM1-Binding Conjugates To Improve Intestinal Permeability by Melkoumov, Alexandre, St-Jean, Isabelle, Banquy, Xavier, Leclair, Grégoire, Leblond Chain, Jeanne

“…Drugs and proteins with poor intestinal permeability have a limited oral bioavailability. To remediate this problem, a receptor-mediated endocytosis and…”
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Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes by Passos Gibson, Victor, Fauquignon, Martin, Ibarboure, Emmanuel, Leblond Chain, Jeanne, Le Meins, Jean-François

“…Blending amphiphilic copolymers and lipids constitutes a novel approach to combine the advantages of polymersomes and liposomes into a new single hybrid…”
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Purification processes of polymeric nanoparticles: How to improve their clinical translation? by Tehrani, Soudeh F., Bharadwaj, Priyanshu, Leblond Chain, Jeanne, Roullin, V. Gaëlle

“…Polymeric nanoparticles, as revolutionary nanomedicines, have offered a new class of diagnostic and therapeutic solutions for a multitude of diseases. With its…”
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Liposomes as Gene Delivery Vectors for Human Placental Cells by Valero, Lucie, Alhareth, Khair, Espinoza Romero, Jenifer, Viricel, Warren, Leblond, Jeanne, Chissey, Audrey, Dhotel, Hélène, Roques, Caroline, Campiol Arruda, Danielle, Escriou, Virginie, Mignet, Nathalie, Fournier, Thierry, Andrieux, Karine

“…Nanomedicine as a therapeutic approach for pregnancy-related diseases could offer improved treatments for the mother while avoiding side effects for the fetus…”
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Bimodal brush-functionalized nanoparticles selective to receptor surface density by Phan, Huu Trong, Lauzon, Dominic, Vallée-Bélisle, Alexis, Angioletti-Uberti, Stefano, Leblond Chain, Jeanne, Giasson, Suzanne

“…Nanoparticles or drug carriers which can selectively bind to cells expressing receptors above a certain threshold surface density are very promising for…”
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Aptamer-based nanotrains and nanoflowers as quinine delivery systems by Cao, Mengyuan, Vial, Anthony, Minder, Laetitia, Guédin, Aurore, Fribourg, Sébastien, Azéma, Laurent, Feuillie, Cécile, Molinari, Michael, Di Primo, Carmelo, Barthélémy, Philippe, Leblond Chain, Jeanne

“…In this study, we designed aptamer-based self-assemblies for the delivery of quinine. Two different architectures were designed by hybridizing quinine binding…”
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Switchable Lipids: From Conformational Switch to Macroscopic Changes in Lipid Vesicles by Phan, Huu Trong, Passos Gibson, Victor, Guédin, Aurore, Ibarboure, Emmanuel, El Mammeri, Nadia, Grélard, Axelle, Le Meins, Jean-François, Dufourc, Erick J, Loquet, Antoine, Giasson, Suzanne, Leblond Chain, Jeanne

“…It has been shown that the use of conformationally pH-switchable lipids can drastically enhance the cytosolic drug delivery of lipid vesicles. Understanding…”
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Poly(N‐methyl‐N‐vinylacetamide): A Strong Alternative to PEG for Lipid‐Based Nanocarriers Delivering siRNA (Adv. Healthcare Mater. 8/2024) by Berger, Manon, Toussaint, François, Ben Djemaa, Sanaa, Maquoi, Erik, Pendeville, Hélène, Evrard, Brigitte, Jerôme, Christine, Leblond Chain, Jeanne, Lechanteur, Anna, Mottet, Denis, Debuigne, Antoine, Piel, Géraldine

“…Lipid Nanoparticle In article 2302712, Denis Mottet, Antoine Debuigne, Géraldine Piel, and co‐workers display a lipid nanoparticle (LNP) designed for siRNA…”
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Molecular Tweezers: Concepts and Applications by Leblond, Jeanne, Petitjean, Anne

“…Taken to the molecular level, the concept of “tweezers” opens a rich and fascinating field at the convergence of molecular recognition, biomimetic chemistry…”
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Lipothioureas as Lipids for Gene Transfection: A Review by Breton, Marie, Leblond, Jeanne, Tranchant, Isabelle, Scherman, Daniel, Bessodes, Michel, Herscovici, Jean, Mignet, Nathalie

“…Non-viral gene therapy requires innovative strategies to achieve higher transfection efficacy. A few years ago, our group proposed bioinspired lipids…”
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Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery by Viricel, Warren, Mbarek, Amira, Leblond, Jeanne

“…We report the use of switchable lipids to improve the endosomal escape and cytosolic delivery of cell‐impermeable compounds. The system is based on a…”
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A rapid and quantitative reversed-phase HPLC-DAD/ELSD method for lipids involved in nanoparticle formulations by Mousli, Yannick, Brachet, Mathilde, Chain, Jeanne Leblond, Ferey, Ludivine

“…Lipid nanoparticles (LNPs) have shown great success as drug delivery systems, especially for mRNA vaccines, as those developed during the Covid-19 pandemics…”
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Aptamer-based liposomes improve specific drug loading and release by Plourde, Kevin, Derbali, Rabeb Mouna, Desrosiers, Arnaud, Dubath, Céline, Vallée-Bélisle, Alexis, Leblond, Jeanne

“…Aptamer technology has shown much promise in cancer therapeutics for its targeting abilities. However, its potential to improve drug loading and release from…”
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Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer by Muntean, Cristina, Blondeel, Eva, Harinck, Laure, Pednekar, Kunal, Prakash, Jai, De Wever, Olivier, Chain, Jeanne Leblond, De Smedt, Stefaan C., Remaut, Katrien, Raemdonck, Koen

“…[Display omitted] Small interfering RNAs (siRNAs) are promising therapeutics for the treatment of human diseases via the induction of sequence-specific gene…”
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