Search Results - "Lebleu, B."

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview by Abes, R, Arzumanov, A A, Moulton, H M, Abes, S, Ivanova, G D, Iversen, P L, Gait, M J, Lebleu, B

“…Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most…”
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TAT peptide internalization: seeking the mechanism of entry by Vivès, E, Richard, J-P, Rispal, C, Lebleu, B

“…During the last decade several peptides have been extensively studied for their ability to translocate across the plasma membrane. These peptides have been…”
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A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus by Vivès, Eric, Brodin, Priscille, Lebleu, Bernard

“…Tat is an 86-amino acid protein involved in the replication of human immunodeficiency virus type 1 (HIV-1). Several studies have shown that exogenous Tat…”
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Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo by Moulton, H M, Fletcher, S, Neuman, B W, McClorey, G, Stein, D A, Abes, S, Wilton, S D, Buchmeier, M J, Lebleu, B, Iversen, P L

“…The cellular uptake of PMOs (phosphorodiamidate morpholino oligomers) can be enhanced by their conjugation to arginine-rich CPPs (cell-penetrating peptides)…”
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Delivery of steric block morpholino oligomers by (R-X-R)₄ peptides: structure-activity studies by Abes, Rachida, Moulton, Hong M, Clair, Philippe, Yang, Sung-Tae, Abes, Said, Melikov, Kamran, Prevot, Paul, Youngblood, Derek S, Iversen, Patrick L, Chernomordik, Leonid V, Lebleu, Bernard

“…Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompetent oligonucleotide analogs such as phosphoramidate morpholino…”
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Cellular uptake and intracellular fate of antisense oligonucleotides by Akhtar, Saghir, Juliano, R.L.

“…Antisense oligonucleotides and short interfering RNAs are routinely used for gene function analysis and are being developed for clinical applications. The…”
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Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides by Abes, S, Moulton, H, Turner, J, Clair, P, Richard, J P, Iversen, P, Gait, M J, Lebleu, B

“…CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins or ONs (oligonucleotides). CPPs…”
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Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides by Abes, R., Arzumanov, A., Moulton, H., Abes, S., Ivanova, G., Gait, M. J., Iversen, P., Lebleu, B.

“…Rerouting the splicing machinery with steric‐block oligonucleotides (ON) might lead to new therapeutic strategies in the treatment of diseases such as…”
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Inhibition of PAI-1 expression in breast cancer carcinoma cells by siRNA at nanomolar range by Meryet-Figuières, M., Resina, S., Lavigne, C., Barlovatz-Meimon, G., Lebleu, B., Thierry, A.R.

“…Plasminogen activator inhibitor type I (PAI-1) plays a central role in metastatic behavior by increasing cells' migratory capacities as shown in several…”
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Different mechanisms for cellular internalization of the HIV‐1 Tat‐derived cell penetrating peptide and recombinant proteins
fused to Tat by Silhol, Michelle, Tyagi, Mudit, Giacca, Mauro, Lebleu, Bernard, Vivès, Eric

“…Translocation through the plasma membrane is a major limiting step for the cellular delivery of macromolecules. A␣promising strategy to overcome this problem…”
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Intracellular Distribution of Microinjected Antisense Oligonucleotides by Leonetti, Jean Paul, Mechti, Nadir, Degols, Genevieve, Gagnor, Corinne, Lebleu, Bernard

“…Antisense oligomers constitute an attractive class of specific tools for genetic analysis and for potential therapeutic applications. Targets with different…”
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One-pot labeling and purification of peptides and proteins with fluorescein maleimide by Vivès, Eric, Lebleu, Bernard

“…Fluorescein labeling of peptides and proteins is required for numerous biophysical or biological experiments such as fluorescence microscopy, fluorescence…”
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Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide by Bongartz, J P, Aubertin, A M, Milhaud, P G, Lebleu, B

“…Recently several groups reported a dramatic improvement of reporter gene transfection efficiency using a fusogenic peptide, derived from the Influenza…”
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Delivering information-rich drugs -prospects and challenges by Lebleu, Bernard

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Selective coupling of a highly basic peptide to an oligonucleotide by Vivès, Eric, Lebleu, Bernard

“…A highly basic peptide (net charge +8) derived from the HIV-1 Tat protein is conjugated with quantitative yield within minutes to a 19 mer rhodamine-labelled…”
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Specific Antiviral Activity of a Poly(L-lysine)-Conjugated Oligodeoxyribonucleotide Sequence Complementary to Vesicular Stomatitis Virus N Protein mRNA Initiation Site by Lemaitre, Marc, Bayard, Bernard, Lebleu, Bernard

“…Antisense oligonucleotides represent an interesting tool for selective inhibition of gene expression, but their efficient introduction within intact cells…”
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Characterisation of membrane oligonucleotide-binding proteins and oligonucleotide uptake in keratinocytes by Laktionov, Pavel P., Dazard, Jean-Eudes, Vives, Eric, Rykova, Elena Y., Piette, Jacques, Vlassov, Valentin V., Lebleu, Bernard

“…Inadequate cellular compartmentalisation of plasmid DNA and antisense oligodeoxynucleotides (ODNs) is generally considered as a major limitation in their use…”
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Tat peptide-mediated cellular delivery: back to basics by Brooks, Hilary, Lebleu, Bernard, Vivès, Eric

“…Peptides are emerging as attractive drug delivery tools. The HIV Tat-derived peptide is a small basic peptide that has been successfully shown to deliver a…”
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Comparative evaluation of seven oligonucleotide analogs as potential antisense agents by Morvan, F, Porumb, H, Degols, G, Lefebvre, I, Pompon, A, Sproat, B. S, Rayner, B, Malvy, C, Lebleu, B, Imbach, J. L

“…12-Mer analogues, representative of seven different classes of structurally modified oligonucleotides and complementary to the same target, have been compared…”
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Vesicular stomatitis virus as model system for studies of antisense oligonucleotide translation arrest by Robbins, I, Lebleu, B

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