Search Results - "Lebl, Michal"

Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability by Makarov, Mikhail, Sanchez Rocha, Alma C., Krystufek, Robin, Cherepashuk, Ivan, Dzmitruk, Volha, Charnavets, Tatsiana, Faustino, Anneliese M., Lebl, Michal, Fujishima, Kosuke, Fried, Stephen D., Hlouchova, Klara

“…Whereas modern proteins rely on a quasi-universal repertoire of 20 canonical amino acids (AAs), numerous lines of evidence suggest that ancient proteins relied…”
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The “One-Bead-One-Compound” Combinatorial Library Method by Lam, Kit S, Lebl, Michal, Krchňák, Viktor

“…Lam et al give a brief description of the one-bead-one-compound concept and a detailed account of the chemistry used for library synthesis, various screening…”
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Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens by Shiryaev, Sergey A., Remacle, Albert G., Ratnikov, Boris I., Nelson, Nicholas A., Savinov, Alexei Y., Wei, Ge, Bottini, Massimo, Rega, Michele F., Parent, Amelie, Desjardins, Roxane, Fugere, Martin, Day, Robert, Sabet, Mojgan, Pellecchia, Maurizio, Liddington, Robert C., Smith, Jeffrey W., Mustelin, Tomas, Guiney, Donald G., Lebl, Michal, Strongin, Alex Y.

“…Pathogens or their toxins, including influenza virus, Pseudomonas, and anthrax toxins, require processing by host proprotein convertases (PCs) to enter host…”
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In memoriam Martin Flegel (1946‐2021)

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Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis by SHIRYAEV, Sergey A, RATNIKOV, Boris I, ALESHIN, Alexander E, KOZLOV, Igor A, NELSON, Nicholas A, LEBL, Michal, SMITH, Jeffrey W, LIDDINGTON, Robert C, STRONGIN, Alex Y

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neuromorphic Processing for Optical Microbead Arrays: Dimensionality Reduction and Contrast Enhancement by Raman, B., Kotseroglou, T., Clark, L., Lebl, M., Gutierrez-Osuna, R.

“…This paper presents a neuromorphic approach for sensor-based machine olfaction that combines a portable chemical detection system based on microbead array…”
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Substrate Cleavage Analysis of Furin and Related Proprotein Convertases by Remacle, Albert G., Shiryaev, Sergey A., Oh, Eok-Soo, Cieplak, Piotr, Srinivasan, Anupama, Wei, Ge, Liddington, Robert C., Ratnikov, Boris I., Parent, Amelie, Desjardins, Roxane, Day, Robert, Smith, Jeffrey W., Lebl, Michal, Strongin, Alex Y.

“…We present the data and the technology, a combination of which allows us to determine the identity of proprotein convertases (PCs) related to the processing of…”
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A high-complexity, multiplexed solution-phase assay for profiling protease activity on microarrays by Kozlov, Igor A, Melnyk, Peter C, Hachmann, John P, Srinivasan, Anu, Shults, Melissa, Zhao, Chanfeng, Musmacker, Joseph, Nelson, Nicholas, Barker, David L, Lebl, Michal

“…We have developed a miniaturized and multiplexed solution assay for the measurement of protease activity in complex samples. This technology can accelerate…”
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Safety-catch and multiply cleavable linkers in solid-phase synthesis by Pátek, Marcel, Lebl, Michal

“…This review article focuses on concepts that incorporate safety‐catch and multiply cleavable linkers in solid‐phase synthesis. Discussed are specific…”
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One-bead-one-structure combinatorial libraries by Lebl, M, Krchnák, V, Sepetov, N F, Seligmann, B, Strop, P, Felder, S, Lam, K S

“…Combinatorial libraries employing the one-bead-one-compound technique are reviewed. Two distinguishing features characterize this technique. First, each…”
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A method for rapid protease substrate evaluation and optimization by Kozlov, Igor A, Melnyk, Peter C, Zhao, Chanfeng, Hachmann, John P, Shevchenko, Veronika, Srinivasan, Anu, Barker, David L, Lebl, Michal

“…We have developed a high throughput assay for the measurement of protease activity in solution. This technology will accelerate research in functional…”
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Economical Parallel Oligonucleotide and Peptide Synthesizer – Pet Oligator by Lebl, Michal, Pistek, Christine, Hachmann, John, Mudra, Petr, Pesek, Vaclav, Pokorny, Vit, Poncar, Pavel, Zenisek, Karel

“…We have developed a small benchtop oligonucleotide synthesizer which allows the scientist to prepare, rapidly and economically, up to 24 oligonucleotides in…”
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Alternative to Piperidine in Fmoc Solid-Phase Synthesis by Hachmann, John, Lebl, Michal

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Substrate Cleavage Analysis of Furin and Related Proprotein Convertases: A COMPARATIVE STUDY by Remacle, Albert G, Shiryaev, Sergey A, Oh, Eok-Soo, Cieplak, Piotr, Srinivasan, Anupama, Wei, Ge, Liddington, Robert C, Ratnikov, Boris I, Parent, Amelie, Desjardins, Roxane, Day, Robert, Smith, Jeffrey W, Lebl, Michal, Strongin, Alex Y

“…We present the data and the technology, a combination of which allows us to determine the identity of proprotein convertases (PCs) related to the processing of…”
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Parallel personal comments on "classical" papers in combinatorial chemistry by Lebl, M

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Molecular Diversity and Libraries of Structures: Synthesis and Screening by Rinnová, Markéta, Lebl, Michal

“…Library, or molecular diversity, approaches are a progressive tool in contemporary investigation of biological interactions and drug discovery. All library…”
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High-throughput peptide synthesis by Lebl, Michal, Hachmann, John

“…The methodologies of high-throughput peptide synthesis are overviewed and discussed. Particular focus is given to the techniques applicable to laboratories…”
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Search for optimal coupling reagent in multiple peptide synthesizer by Hachmann, John, Lebl, Michal

“…Ten different coupling reagents and their combinations were tested in parallel in the synthesis of four model peptide sequences. Significant differences were…”
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Solid-phase synthesis on planar supports by Lebl, Michal

“…Planar supports represent a unique opportunity in designing novel approaches to solid‐phase synthesis of peptides and small organic molecules. Published work…”
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Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses by Shiryaev, Sergey A, Kozlov, Igor A, Ratnikov, Boris I, Smith, Jeffrey W, Lebl, Michal, Strongin, Alex Y

“…Regulated proteolysis of the polyprotein precursor by the NS2B-NS3 protease is required for the propagation of infectious virions. Unless the structural and…”
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