Search Results - "Lebish, Eric J"

MK2 Promotes the Development and Progression of Pancreatic Neuroendocrine Tumors Mediated by Macrophages and Metabolomic Factors by Jacenik, Damian, Lebish, Eric J., Beswick, Ellen J.

“…Cases of pancreatic neuroendocrine tumors (PNETs) are growing in number, and new treatment options are needed in order to improve patient outcomes. The…”
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MK2 drives progression of pancreas and colon cancers by suppressing CD8 + T cell cytotoxic function and is a potential immunotherapy target by Jacenik, Damian, Lebish, Eric J, Beswick, Ellen J

“…Immune cell composition is a critical and dynamic component of the tumor microenvironment, which has an impact on immunosuppression and progression of cancer…”
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MK2 Inhibitors as a Potential Crohn's Disease Treatment Approach for Regulating MMP Expression, Cleavage of Checkpoint Molecules and T Cell Activity by Lebish, Eric J, Morgan, Natalie J, Valentine, John F, Beswick, Ellen J

“…Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two major forms of inflammatory bowel disease (IBD), which are incurable chronic immune-mediated…”
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Mucosal-associated invariant T cells modulate innate immune cells and inhibit colon cancer growth by Cheng, Olivia J, Lebish, Eric J, Jensen, Owen, Jacenik, Damian, Trivedi, Shubhanshi, Cacioppo, Jackson G, Aubé, Jeffrey, Beswick, Ellen J, Leung, Daniel T

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal…”
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5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies by Wong, Jasmine C., Weinfurtner, Kelley M., Westover, Tamara, Kim, Jangkyung, Lebish, Eric J., del pilar Alzamora, Maria, Huang, Benjamin J., Walsh, Michael, Abdelhamed, Sherif, Ma, Jing, Klco, Jeffery M., Shannon, Kevin

“…Monosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome…”
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Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity by López, Diego A, Apostol, April C, Lebish, Eric J, Valencia, Clint H, Romero-Mulero, Mari Carmen, Pavlovich, Polina V, Hernandez, Gloria E, Forsberg, E Camilla, Cabezas-Wallscheid, Nina, Beaudin, Anna E

“…Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation and infection, causing both acute and persistent changes to quiescence,…”
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MAIT cell-mediated inhibition of colorectal tumor growth is associated with increase in IL-5 and accumulation of eosinophils in the tumor microenvironment by Cheng, Olivia J, Lebish, Eric J, Jensen, Owen, Jacenik, Damian, Trivedi, Shubhanshi, Beswick, Ellen J, Leung, Daniel T

“…Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes with cytotoxic and pro-inflammatory function and are enriched in mucosal tissues such…”
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