Search Results - "Lebioda, Lukasz"

Data mining of metal ion environments present in protein structures by Zheng, Heping, Chruszcz, Maksymilian, Lasota, Piotr, Lebioda, Lukasz, Minor, Wladek

“…Analysis of metal–protein interaction distances, coordination numbers, B-factors (displacement parameters), and occupancies of metal-binding sites in protein…”
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Structures of K42N and K42Y sperm whale myoglobins point to an inhibitory role of distal water in peroxidase activity by Wang, Chunxue, Lovelace, Leslie L., Sun, Shengfang, Dawson, John H., Lebioda, Lukasz

“…Sperm whale myoglobin (Mb) functions as an oxygen‐storage protein, but in the ferric state it possesses a weak peroxidase activity which enables it to carry…”
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Fluoride Inhibition of Enolase:  Crystal Structure and Thermodynamics by Qin, Jie, Chai, Geqing, Brewer, John M, Lovelace, Leslie L, Lebioda, Lukasz

“…Enolase is a dimeric metal-activated metalloenzyme which uses two magnesium ions per subunit:  the strongly bound conformational ion and the catalytic ion that…”
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Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis by Klimecka, Maria M., Chruszcz, Maksymilian, Font, Jose, Skarina, Tatiana, Shumilin, Igor, Onopryienko, Olena, Porebski, Przemyslaw J., Cymborowski, Marcin, Zimmerman, Matthew D., Hasseman, Jeremy, Glomski, Ian J., Lebioda, Lukasz, Savchenko, Alexei, Edwards, Aled, Minor, Wladek

“…For the last decade, worldwide efforts for the treatment of anthrax infection have focused on developing effective vaccines. Patients that are already infected…”
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Molecular Characterization of a Novel Short-chain Dehydrogenase/Reductase That Reduces All-trans-retinal by Haeseleer, Françoise, Huang, Jing, Lebioda, Lukasz, Saari, John C., Palczewski, Krzysztof

“…The reduction of all-trans-retinal in photoreceptor outer segments is the first step in the regeneration of bleached visual pigments. We report here the…”
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The Crystal Structure and Amino Acid Sequence of Dehaloperoxidase from Amphitrite ornata Indicate Common Ancestry with Globins by LaCount, Michael W., Zhang, Erli, Chen, Yung Pin, Han, Kaiping, Whitton, Margaret M., Lincoln, David E., Woodin, Sarah A., Lebioda, Lukasz

“…The full-length, protein coding sequence for dehaloperoxidase was obtained using a reverse genetic approach and a cDNA library from marine worm Amphitrite…”
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Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors by Phan, J, Steadman, D J, Koli, S, Ding, W C, Minor, W, Dunlap, R B, Berger, S H, Lebioda, L

“…Thymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and some other neoplasms. The emergence of resistance to the treatment is…”
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Mechanism of Enolase:  The Crystal Structure of Asymmetric Dimer Enolase−2-Phospho-d-glycerate/Enolase−Phosphoenolpyruvate at 2.0 Å Resolution by Zhang, Erli, Brewer, John M, Minor, Wladek, Carreira, Lionel A, Lebioda, Lukasz

“…Enolase, a glycolytic enzyme that catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to form phosphoenolpyruvate (PEP), is a homodimer in all eukaryotes…”
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Crystal structure of human prostatic acid phosphatase by Jakob, Clarissa G., Lewinski, Krzysztof, Kuciel, Radoslawa, Ostrowski, Wlodzimierz, Lebioda, Lukasz

“…BACKGROUND Prostatic acid phosphatase (hPAP) is a major product of the human prostate gland, yet its physiological substrate remains unknown. METHODS Human…”
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Structural Origins of l(+)-Tartrate Inhibition of Human Prostatic Acid Phosphatase by LaCount, Michael W., Handy, George, Lebioda, Lukasz

“…Acid phosphatase activity in the blood serum is usually separated into tartrate-resistant and tartrate-refractory, which is reported as the prostatic acid…”
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Expression, Purification and the 1.8Å Resolution Crystal Structure of Human Neuron Specific Enolase by Chai, Geqing, Brewer, John M., Lovelace, Leslie L., Aoki, Takashi, Minor, Wladek, Lebioda, Lukasz

“…Human neuron-specific enolase (NSE) or isozyme gamma has been expressed with a C-terminal His-tag in Escherichia coli. The enzyme has been purified,…”
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Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement by Lovelace, Leslie L., Cooper, Christopher L., Sodetz, James M., Lebioda, Lukasz

“…C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like “membrane attack complex” (MAC) of complement. The MAC…”
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The H159A Mutant of Yeast Enolase 1 Has Significant Activity by Brewer, John M., Holland, Michael J., Lebioda, Lukasz

“…The function of His159 in the enolase mechanism is disputed. Recently, Vinarov and Nowak (Biochemistry (1999) 38, 12138–12149) prepared the H159A mutant of…”
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Complexes of Dual-Function Hemoglobin/Dehaloperoxidase with Substrate 2,4,6-Trichlorophenol Are Inhibitory and Indicate Binding of Halophenol to Compound I by Wang, Chunxue, Lovelace, Leslie L, Sun, Shengfang, Dawson, John H, Lebioda, Lukasz

“…The hemoglobin of sea worm Amphitrite ornata, which for historical reasons is abbreviated as DHP for dehaloperoxidase, has two physiological functions: it…”
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Response to boguslaw stec's letter to the editor of protein science by Celeste, Lesa, Lovelace, Leslie, Lebioda, Lukasz

“…PDB Code(s): 4JIM, 4JJZ, 4JJK, 4JKI…”
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Influence of heme environment structure on dioxygen affinity for the dual function Amphitrite ornata hemoglobin/dehaloperoxidase. Insights into the evolutional structure–function adaptations by Sun, Shengfang, Sono, Masanori, Wang, Chunxue, Du, Jing, Lebioda, Lukasz, Dawson, John H.

“…•Structural factors influencing the O2 affinities of DHP and SW Mb have been examined.•The distal His Nε–heme iron distance increase is correlated with…”
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Amphitrite ornata Dehaloperoxidase (DHP): Investigations of Structural Factors That Influence the Mechanism of Halophenol Dehalogenation Using “Peroxidase-like” Myoglobin Mutants and “Myoglobin-like” DHP Mutants by Du, Jing, Huang, Xiao, Sun, Shengfang, Wang, Chunxue, Lebioda, Lukasz, Dawson, John H

“…Dehaloperoxidase (DHP), discovered in the marine terebellid polychaete Amphitrite ornata, is the first heme-containing globin with a peroxidase activity. The…”
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Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit by Slade, Daniel J., Lovelace, Leslie L., Chruszcz, Maksymilian, Minor, Wladek, Lebioda, Lukasz, Sodetz, James M.

“…Human C8 is one of five complement components (C5b, C6, C7, C8, and C9) that assemble on bacterial membranes to form a porelike structure referred to as the…”
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Isomerization of the alkyl ligand in (Me2NCS2)Pd(PR3)(alkyl) complexes. Influences of heteroatom substituents in the alkyl group on the alkyl isomerization equilibria and stability of alkylmetal complexes by Reger, Daniel L, Garza, David G, Lebioda, Lukasz

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Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity by Qin, Jie, Chai, Geqing, Brewer, John M., Lovelace, Leslie L., Lebioda, Lukasz

“…In the presence of magnesium, enolase catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis and the reverse…”
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