Search Results - "Lebel, Réjean"

Diffusion MRI monitoring of specific structures in the irradiated rat brain by Constanzo, Julie, Dumont, Matthieu, Lebel, Réjean, Tremblay, Luc, Whittingstall, Kevin, Masson‐Côté, Laurence, Geha, Sameh, Sarret, Philippe, Lepage, Martin, Paquette, Benoit, Descoteaux, Maxime

“…Purpose The analysis of biological and mesoscopic structures properties by diffusion MRI (dMRI) in brain after radiation therapy remains challenging. In our…”
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Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions by Sikpa, Dina, Whittingstall, Lisa, Savard, Martin, Lebel, Réjean, Côté, Jérôme, McManus, Stephen, Chemtob, Sylvain, tin, David, Lepage, Martin, Gobeil, Fernand

“…The blood–brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous…”
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A comprehensive review on controls in molecular imaging: lessons from MMP-2 imaging by Lebel, Réjean, Lepage, Martin

“…Metalloproteinases (MMPs), including MMP-2, play critical roles in tissue remodeling and are involved in a large array of pathologies, including cancer,…”
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Characterization of microparticles of iron oxide for magnetic resonance imaging by Fouquet, Jérémie P., Sikpa, Dina, Lebel, Réjean, Sibgatulin, Renat, Krämer, Martin, Herrmann, Karl-Heinz, Deistung, Andreas, Tremblay, Luc, Reichenbach, Jürgen R., Lepage, Martin

“…Microparticles of iron oxide (MPIOs) are increasingly used for contrast generation in magnetic resonance imaging (MRI). In particular, Dynabeads® MyOne™…”
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Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue by Richard, Marie Anne, Blondin, Denis P., Noll, Christophe, Lebel, Réjean, Lepage, Martin, Carpentier, André C.

“…Background [ 11 C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose…”
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Single cell transfection using plasmid decorated AFM probes by Cuerrier, Charles M., Lebel, Réjean, Grandbois, Michel

“…Eukaryotic cells were individually transfected using commercially available atomic force microscope tips decorated with plasmidic DNA encoding for the…”
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Real-Time Microfluidic Blood-Counting System for PET and SPECT Preclinical Pharmacokinetic Studies by Convert, Laurence, Lebel, Réjean, Gascon, Suzanne, Fontaine, Réjean, Pratte, Jean-François, Charette, Paul, Aimez, Vincent, Lecomte, Roger

“…Small-animal nuclear imaging modalities have become essential tools in the development process of new drugs, diagnostic procedures, and therapies…”
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New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging by Jastrzȩbska, Beata, Lebel, Réjean, Therriault, Hélène, McIntyre, J. Oliver, Escher, Emanuel, Guérin, Brigitte, Paquette, Benoit, Neugebauer, Witold A, Lepage, Martin

“…We designed and synthesized a novel contrast agent (CA) to image the activity of matrix metalloproteinase-2 (MMP-2) in a tumor, noninvasively using magnetic…”
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Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model by Lebel, Réjean, Jastrzębska, Beata, Therriault, Hélène, Cournoyer, Marie-Michèle, McIntyre, J. Oliver, Escher, Emanuel, Neugebauer, Witold, Paquette, Benoit, Lepage, Martin

“…A novel MRI proteinase‐modulated contrast agent (PCA) was developed to detect the activity of the proinvasive enzyme matrix metalloproteinase‐2 (MMP‐2) in…”
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Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation by Cuerrier, Charles M., Gagner, Andréanne, Lebel, Réjean, Gobeil Jr, Fernand, Grandbois, Michel

“…The endothelium is closely implicated in the control and maintenance of the vascular homeostasis. The functions of endothelial cells are highly regulated by…”
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Determination of an Optimal Pharmacokinetic Model of 18F-FET for Quantitative Applications in Rat Brain Tumors by Richard, Marie Anne, Fouquet, Jérémie P, Lebel, Réjean, Lepage, Martin

“…O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is a radiolabeled artificial amino acid used in PET for tumor delineation and grading. The present study compares…”
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Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment by González, Laura Martínez, Bourissai, Adam, Lessard-Beaudoin, Mélissa, Lebel, Réjean, Tremblay, Luc, Lepage, Martin, Graham, Rona K.

“…Olfactory dysfunction and atrophy of olfactory brain regions are observed early in mild cognitive impairment and Alzheimer disease. Despite substantial…”
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Single-molecule dynamic force spectroscopy of the fibronectin–heparin interaction by Mitchell, Gabriel, Lamontagne, Charles-Antoine, Lebel, Réjean, Grandbois, Michel, Malouin, François

“…The integrity of cohesive tissues strongly depends on the presence of the extracellular matrix, which provides support and anchorage for cells. The fibronectin…”
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Automated detection and quantification of breast cancer brain metastases in an animal model using democratized machine learning tools by Sikpa, Dina, Fouquet, Jérémie P., Lebel, Réjean, Diamandis, Phedias, Richer, Maxime, Lepage, Martin

“…Advances in digital whole-slide imaging and machine learning (ML) provide new opportunities for automated examination and quantification of histopathological…”
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Robust arterial input function surrogate measurement from the superior sagittal sinus complex signal for fast dynamic contrast‐enhanced MRI in the brain by Bourassa‐Moreau, Benoît, Lebel, Réjean, Gilbert, Guillaume, Mathieu, David, Lepage, Martin

“…Purpose Accurately estimating the arterial input function for dynamic contrast‐enhanced MRI is challenging. An arterial input function is typically determined…”
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Cerebrovascular inflammation promotes the formation of brain metastases by Sikpa, Dina, Whittingstall, Lisa, Fouquet, Jérémie P., Radulska, Adrianna, Tremblay, Luc, Lebel, Réjean, Paquette, Benoit, Lepage, Martin

“…Brain metastases are the most prevalent intracranial malignancy. Patient outcome is poor and treatment options are limited. Hence, new avenues must be explored…”
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Cerebrovascular MRI in the mouse without an exogenous contrast agent by Fouquet, Jérémie P., Lebel, Réjean, Cahill, Lindsay S., Sled, John G., Tremblay, Luc, Lepage, Martin

“…Purpose To assess the effect of a variety of anesthetic regimes on T2∗‐weighted MRI of the mouse brain and to determine the optimal regimes to perform…”
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Increased precision in the intravascular arterial input function with flow compensation by Bourassa‐Moreau, Benoît, Lebel, Réjean, Gilbert, Guillaume, Mathieu, David, Lepage, Martin

“…Purpose In this study, we investigate the effects of pulsatile flow and inflow on dynamic susceptibility‐contrast MRI intravascular arterial input function…”
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Conversion of arterial input functions for dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET by Poulin, Eric, Lebel, Réjean, Croteau, Etienne, Blanchette, Marie, Tremblay, Luc, Lecomte, Roger, Bentourkia, M'hamed, Lepage, Martin

“…Reaching the full potential of magnetic resonance imaging (MRI)‐positron emission tomography (PET) dual modality systems requires new methodologies in…”
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In Vivo Endomicroscopy of Lung Injury and Repair in ARDS: Potential Added Value to Current Imaging by Lesur, Olivier, Chagnon, Frédéric, Lebel, Réjean, Lepage, Martin

“…Standard clinical imaging of the acute respiratory distress syndrome (ARDS) lung lacks resolution and offers limited possibilities in the exploration of the…”
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