Search Results - "Lebel, Marie‐Ève"

Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles by Lebel, Marie-Ève, Chartrand, Karine, Tarrab, Esther, Savard, Pierre, Leclerc, Denis, Lamarre, Alain

“…The recent development of novel immunotherapies is revolutionizing cancer treatment. These include, for example, immune checkpoint blockade, immunomodulation,…”
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CD5 levels define functionally heterogeneous populations of naïve human CD4+ T cells by Sood, Aditi, Lebel, Marie‐Ève, Dong, Mengqi, Fournier, Marilaine, Vobecky, Suzanne J., Haddad, Élie, Delisle, Jean‐Sébastien, Mandl, Judith N., Vrisekoop, Nienke, Melichar, Heather J.

“…Studies in murine models show that subthreshold TCR interactions with self‐peptide are required for thymic development and peripheral survival of naïve T…”
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Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates by Lebel, Marie-Ève, Coutelier, Marie, Galipeau, Maria, Kleinman, Claudia L., Moon, James J., Melichar, Heather J.

“…Medullary thymic epithelial cells (mTEC) contribute to the development of T cell tolerance by expressing and presenting tissue-restricted antigens (TRA), so…”
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CD5 levels reveal distinct basal T‐cell receptor signals in T cells from non‐obese diabetic mice by Dong, Mengqi, Audiger, Cindy, Adegoke, Adeolu, Lebel, Marie‐Ève, Valbon, Stefanie F, Anderson, Colin C, Melichar, Heather J, Lesage, Sylvie

“…Type 1 diabetes in non‐obese diabetic (NOD) mice occurs when autoreactive T cells eliminate insulin producing pancreatic β cells. While extensively studied in…”
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Differential interferon‐gamma production potential among naïve CD4+ T cells exists prior to antigen encounter by Sood, Aditi, Lebel, Marie‐Ève, Fournier, Marilaine, Rogers, Dakota, Mandl, Judith N, Melichar, Heather J

“…Individual CD4+ T cells can become one of a number of helper (Th) lineages with distinct effector functions. However, whether biases in Th potential exist…”
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The ICOS–ICOSL pathway tunes thymic selection by Dong, Mengqi, Chang, Jinsam, Lebel, Marie‐Ève, Gervais, Noémie, Fournier, Marilaine, Mallet Gauthier, Ève, Suh, Woong‐Kyung, Melichar, Heather J

“…Negative selection of developing T cells plays a significant role in T‐cell tolerance to self‐antigen. This process relies on thymic antigen‐presenting cells…”
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Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor by Artusa, Patricio, Lebel, Marie-Ève, Barbier, Camille, Memari, Babak, Salehi-Tabar, Reyhaneh, Karabatsos, Sophia, Ismailova, Aiten, Melichar, Heather J, White, John H

“…Vitamin D deficiency is associated with the development of autoimmunity, which arises from defects in T cell tolerance to self-antigens. Interactions of…”
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Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle by Lebel, Marie-Ève, Langlois, Marie-Pierre, Daudelin, Jean-François, Tarrab, Esther, Savard, Pierre, Leclerc, Denis, Lamarre, Alain

“…The increasing use of plant viruses for the development of new vaccines and immunotherapy approaches poses questions regarding the mechanism by which the…”
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Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection by Lebel, Marie-Ève, Daudelin, Jean-François, Chartrand, Karine, Tarrab, Esther, Kalinke, Ulrich, Savard, Pierre, Labrecque, Nathalie, Leclerc, Denis, Lamarre, Alain

“…Developing new adjuvants and vaccination strategies is of paramount importance to successfully fight against many life-threatening infectious diseases and…”
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Pre-existing chromatin accessibility and gene expression differences among naive CD4 + T cells influence effector potential by Rogers, Dakota, Sood, Aditi, Wang, HanChen, van Beek, Jasper J P, Rademaker, Thomas J, Artusa, Patricio, Schneider, Caitlin, Shen, Connie, Wong, Dylan C, Bhagrath, Aanya, Lebel, Marie-Ève, Condotta, Stephanie A, Richer, Martin J, Martins, Andrew J, Tsang, John S, Barreiro, Luis B, François, Paul, Langlais, David, Melichar, Heather J, Textor, Johannes, Mandl, Judith N

“…CD4 T cells have a remarkable potential to differentiate into diverse effector lineages following activation. Here, we probe the heterogeneity present among…”
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Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants by Lebel, Marie-Ève, Chartrand, Karine, Leclerc, Denis, Lamarre, Alain

“…Vaccines are considered one of the greatest medical achievements in the battle against infectious diseases. However, the intractability of various diseases…”
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Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance by This, Sébastien, Valbon, Stefanie F, Lebel, Marie-Ève, Melichar, Heather J

“…The ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and…”
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Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference by Chartrand, Karine, Lebel, Marie-Ève, Tarrab, Esther, Savard, Pierre, Leclerc, Denis, Lamarre, Alain

“…Although vaccination has been an effective way of preventing infections ever since the eighteenth century, the generation of therapeutic vaccines and…”
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Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line by Provost, Chantale, Jia, Jian Jun, Music, Nedzad, Lévesque, Cynthia, Lebel, Marie-Ève, del Castillo, Jérôme R E, Jacques, Mario, Gagnon, Carl A

“…Airborne transmitted pathogens, such as porcine reproductive and respiratory syndrome virus (PRRSV), need to interact with host cells of the respiratory tract…”
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Adverse Event Rates and Classifications in Medial Opening Wedge High Tibial Osteotomy by Martin, Robin, Birmingham, Trevor B., Willits, Kevin, Litchfield, Robert, LeBel, Marie-Eve, Giffin, J. Robert

“…Background: Previously reported complications in medial opening wedge (MOW) high tibial osteotomy (HTO) vary considerably in both rate and severity. Purpose:…”
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MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells by Collin, Roxanne, Lombard-Vadnais, Félix, Hillhouse, Erin E, Lebel, Marie-Ève, Chabot-Roy, Geneviève, Melichar, Heather J, Lesage, Sylvie

“…It is becoming increasingly clear that unconventional T cell subsets, such as NKT, γδ T, mucosal-associated invariant T, and CD8αα T cells, each play distinct…”
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NR4A3 Mediates Thymic Negative Selection by Boulet, Salix, Odagiu, Livia, Dong, Mengqi, Lebel, Marie-Ève, Daudelin, Jean-François, Melichar, Heather J., Labrecque, Nathalie

“…Abstract Central tolerance aims to limit the production of T lymphocytes bearing TCR with high affinity for self-peptide presented by MHC molecules. The…”
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Type I interferon induced during chronic viral infection favors B‐cell development in the thymus by Valbon, Stefanie F, Lebel, Marie‐Eve, Feldman, H Alex, Condotta, Stephanie A, Dong, Mengqi, Giordano, Daniela, Waggoner, Stephen N, Melichar, Heather J, Richer, Martin J

“…Chronic viral infections cause thymic involution yet the potential for broader, longer‐term impact on thymic composition remains unexplored. Here we show that…”
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Analysis of Energy-Based Metrics for Laparoscopic Skills Assessment by Poursartip, Behnaz, LeBel, Marie-Eve, Patel, Rajni V., Naish, Michael D., Trejos, Ana Luisa

“…Objective: The complexity of minimally invasive surgery (MIS) requires that trainees practice MIS skills in numerous training sessions. The goal of these…”
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Arthroscopic Versus Mini-open Rotator Cuff Repair: A Randomized Trial and Meta-analysis by MacDermid, Joy C., Bryant, Dianne, Holtby, Richard, Razmjou, Helen, Faber, Kenneth, Balyk, Robert, Boorman, Richard, Sheps, David, McCormack, Robert, Athwal, George, Hollinshead, Robert, Lo, Ian, Bicknell, Ryan, Mohtadi, Nicholas, Bouliane, Martin, Glasgow, Donald, Lebel, Marie-Eve, Lalani, Aleem, Moola, Farhad O., Litchfield, Robert, Moro, Jaydeep, MacDonald, Peter, Bergman, J.W., Bury, Jeff, Drosdowech, Darren

“…Background: Patients with complete rotator cuff tears who fail a course of nonoperative therapy can benefit from surgical repair. Purpose: This randomized…”
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