Comparative immunochemical study of the hemagglutinins of Cl. botulinum A and B

The authors demonstrated an incomplete indentity of Cl. botulinum hemagglutinins of types A and B in the double diffusion reaction in agar gel, and their difference by electrophoretic mobility. Some differences in the interaction of hemagglutinins A and B with human erythrocytes were found by the he...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 48
Main Authors:	Ivanova, L G, Kliucheva, V V, Blagoveshchenskiĭ, V A, Lebedenko, G I, Saprykina, T P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-02-1977
Subjects:	Agglutinins - isolation & purification Carbohydrates - pharmacology Chemical Phenomena Chemistry Clostridium botulinum - immunology Depression, Chemical Hemagglutination - drug effects Hemagglutination Tests Hemagglutinins - isolation & purification Immunodiffusion Immunoelectrophoresis
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Summary:	The authors demonstrated an incomplete indentity of Cl. botulinum hemagglutinins of types A and B in the double diffusion reaction in agar gel, and their difference by electrophoretic mobility. Some differences in the interaction of hemagglutinins A and B with human erythrocytes were found by the hemagglutination inhibition method; apparently, of the principal significance in the relization of the reaction of human erythrocyte hemagglutination with hemagglutinins of Cl. botulinum, types A and B, was the OH-group position in the C4 galactose of the mucopolysaccharides of the erythrocyte cell wall. Apart from C4, apparently, for hemagglutinin of types A of significance was the reactive capacity of C1 and C2 galactose atoms, whereas for hemagglutinin of type B--free OH-group in C2 galactose atom.
ISSN:	0372-9311