Search Results - "Lebeau, Benjamin"

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors by Kim, HaEun, Lebeau, Benjamin, Papadopoli, David, Jovanovic, Predrag, Russo, Mariana, Avizonis, Daina, Morita, Masahiro, Afzali, Farzaneh, Ursini-Siegel, Josie, Postovit, Lynne-Marie, Witcher, Michael, Topisirovic, Ivan

“…Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin…”
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Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy? by Jangal, Maïka, Lebeau, Benjamin, Witcher, Michael

“…: Epigenetic modifications are important regulators of transcription and appropriate gene expression answering an environmental stimulus. In cancer, these…”
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Studying the Oncogenic and Epigenetic Impact of CTCF Loss of Heterozygosity and Zinc-Finger 1 Mutation in Breast Cancer by Lebeau, Benjamin

“…While epigenetic processes are important drivers of tumor progression, the contribution of deregulated chromatin architecture, including topologically…”
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Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation by Lebeau, Benjamin, Zhao, Kaiqiong, Jangal, Maika, Zhao, Tiejun, Guerra, Maria, Greenwood, Celia M T, Witcher, Michael

“…Abstract Defining the impact of missense mutations on the recognition of DNA motifs is highly dependent on bioinformatic tools that define DNA binding…”
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Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth by Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane

“…Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such…”
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3D chromatin remodeling potentiates transcriptional programs driving cell invasion by Lebeau, Benjamin, Jangal, Maïka, Zhao, Tiejun, Wong, Cheng Kit, Wong, Nolan, Cañedo, Eduardo Cepeda, Hébert, Steven, Aguilar-Mahecha, Adriana, Chabot, Catherine, Buchanan, Marguerite, Catterall, Rachel, McCaffrey, Luke, Deblois, Geneviève, Kleinman, Claudia, Park, Morag, Basik, Mark, Witcher, Michael

“…The contribution of deregulated chromatin architecture, including topologically associated domains (TADs), to cancer progression remains ambiguous…”
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STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer by Totten, Stephanie P., Im, Young Kyuen, Cepeda Cañedo, Eduardo, Najyb, Ouafa, Nguyen, Alice, Hébert, Steven, Ahn, Ryuhjin, Lewis, Kyle, Lebeau, Benjamin, La Selva, Rachel, Sabourin, Valérie, Martínez, Constanza, Savage, Paul, Kuasne, Hellen, Avizonis, Daina, Santos Martínez, Nancy, Chabot, Catherine, Aguilar-Mahecha, Adriana, Goulet, Marie-Line, Dankner, Matthew, Witcher, Michael, Petrecca, Kevin, Basik, Mark, Pollak, Michael, Topisirovic, Ivan, Lin, Rongtuan, Siegel, Peter M., Kleinman, Claudia L., Park, Morag, St-Pierre, Julie, Ursini-Siegel, Josie

“…Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS…”
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POGZ promotes homology‐directed DNA repair in an HP1‐dependent manner by Heath, John, Cheyou, Estelle Simo, Findlay, Steven, Luo, Vincent M, Carpio, Edgar Pinedo, Lee, Jeesan, Djerir, Billel, Chen, Xiaoru, Morin, Théo, Lebeau, Benjamin, Karam, Martin, Bagci, Halil, Grapton, Damien, Ursini‐Siegel, Josie, Côté, Jean‐Francois, Witcher, Michael, Richard, Stéphane, Maréchal, Alexandre, Orthwein, Alexandre

“…The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that…”
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