Search Results - "Lebar, Blaž"

Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability by Lebar, Blaž, Zidar, Mitja, Mravljak, Janez, Šink, Roman, Žula, Aleš, Pajk, Stane

“…The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and…”
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Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies by Proj, Matic, Zidar, Mitja, Lebar, Blaž, Strašek, Nika, Miličić, Goran, Žula, Aleš, Gobec, Stanislav

“…[Display omitted] •Computational screening yielded 44 new viscosity-reducing agents on two model mAbs.•Dual excipients for viscosity reduction and solution…”
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Polysorbate stability: Effects of packaging materials, buffers, counterions, and pH by Lebar, Blaž, Lekić, Tinkara, Košir, Pija, Kastelic, Miha, Zidar, Mitja, Mravljak, Janez, Pajk, Stane

“…[Display omitted] •Leachables from plastic containers fully suppress chemical hydrolysis of PS.•Results suggest base-catalysed hydrolysis of PS in histidine,…”
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The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions by Prašnikar, Monika, Proj, Matic, Bjelošević Žiberna, Maja, Lebar, Blaž, Knez, Benjamin, Kržišnik, Nika, Roškar, Robert, Gobec, Stanislav, Grabnar, Iztok, Žula, Aleš, Ahlin Grabnar, Pegi

“…[Display omitted] •Electrostatic interactions mainly contribute to the viscosity of protein solutions.•Novel proline-based compounds reduce the viscosity of…”
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A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticals by Lebar, Blaž, Orehova, Maria, Japelj, Boštjan, Šprager, Ernest, Podlipec, Rok, Knaflič, Tilen, Urbančič, Iztok, Knez, Benjamin, Zidar, Mitja, Cerar, Jure, Mravljak, Janez, Žula, Aleš, Arčon, Denis, Plavec, Janez, Pajk, Stane

“…[Display omitted] The excipient selection process plays a crucial role in biopharmaceutical formulation development to ensure the long-term stability of the…”
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