Search Results - "Leavitt, Blair R."

Iron dysregulation in Huntington's disease by Muller, Michelle, Leavitt, Blair R.

“…Huntington's disease (HD) is one of many neurodegenerative diseases with reported alterations in brain iron homeostasis that may contribute to…”
Get full text

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis by Byrne, Lauren M, MRes, Rodrigues, Filipe B, MD, Blennow, Kaj, Prof, Durr, Alexandra, Prof, Leavitt, Blair R, Prof, Roos, Raymund A C, Prof, Scahill, Rachael I, PhD, Tabrizi, Sarah J, Prof, Zetterberg, Henrik, Prof, Langbehn, Douglas, Prof, Wild, Edward J, Dr

“…Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We…”
Get full text

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Owen, Gail, PhD, Durr, Alexandra, MD, Leavitt, Blair R, MDCM, Roos, Raymund A, Prof, Borowsky, Beth, PhD, Landwehrmeyer, Bernhard, Prof, Frost, Chris, Prof, Johnson, Hans, PhD, Craufurd, David, MD, Reilmann, Ralf, MD, Stout, Julie C, Prof, Langbehn, Douglas R, Prof

“…Summary Background TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of…”
Get full text

Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
Get full text

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Durr, Alexandra, MD, Roos, Raymund AC, MD, Leavitt, Blair R, FRCPC, Jones, Rebecca, MSc, Landwehrmeyer, G Bernhard, MD, Fox, Nick C, MD, Johnson, Hans, PhD, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Craufurd, David, FRCPsych, Frost, Chris, PhD, Langbehn, Douglas R, MD, Reilmann, Ralf, MD, Stout, Julie C, PhD

“…Summary Background TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals…”
Get full text

Development of biomarkers for Huntington's disease by Weir, David W, BSc, Sturrock, Aaron, MBBS, Leavitt, Blair R, MDCM

“…Summary Huntington's disease is an autosomal dominant, progressive neurodegenerative disorder, for which there is no disease-modifying treatment. By use of…”
Get full text

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles by Kulkarni, Jayesh A, Thomson, Sarah B, Zaifman, Josh, Leung, Jerry, Wagner, Pamela K, Hill, Austin, Tam, Yuen Yi C, Cullis, Pieter R, Petkau, Terri L, Leavitt, Blair R

“…Lipid nanoparticle (LNP) formulations of nucleic acid are leading vaccine candidates for COVID-19, and enabled the first approved RNAi therapeutic, Onpattro…”
Get more information

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data by Tabrizi, Sarah J, Langbehn, Douglas R, Leavitt, Blair R, Roos, Raymund AC, Durr, Alexandra, Craufurd, David, Kennard, Christopher, Hicks, Stephen L, Fox, Nick C, Scahill, Rachael I, Borowsky, Beth, Tobin, Allan J, Rosas, H Diana, Johnson, Hans, Reilmann, Ralf, Landwehrmeyer, Bernhard, Stout, Julie C

“…Summary Background Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in…”
Get full text

Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey Central Nervous System by Galvan, Adriana, Petkau, Terri L, Hill, Austin M, Korecki, Andrea J, Lu, Ge, Choi, Diane, Rahman, Kazi, Simpson, Elizabeth M, Leavitt, Blair R, Smith, Yoland

“…Viral vectors made from adeno-associated virus (AAV) have emerged as preferred tools in basic and translational neuroscience research to introduce or modify…”
Get more information

The Clinical and Genetic Features of Huntington Disease by Sturrock, Aaron, Leavitt, Blair R.

“…Huntington disease (HD) is a dominantly inherited neurodegenerative disorder that usually presents in adulthood with characteristic motor and cognitive…”
Get full text

FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD by Life, Benjamin, Petkau, Terri L., Cruz, Giuliano N.F., Navarro-Delgado, Erick I., Shen, Ning, Korthauer, Keegan, Leavitt, Blair R.

“…Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is…”
Get full text

Potential biomarkers to follow the progression and treatment response of Huntington's disease by Disatnik, Marie-Hélène, Joshi, Amit U, Saw, Nay L, Shamloo, Mehrdad, Leavitt, Blair R, Qi, Xin, Mochly-Rosen, Daria

“…Huntington's disease (HD) is a rare genetic disease caused by expanded polyglutamine repeats in the huntingtin protein resulting in selective neuronal loss…”
Get full text

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice by Petkau, Terri L, Blanco, Jake, Leavitt, Blair R

“…Abstract Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD),…”
Get full text

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease by Björkqvist, Maria, Wild, Edward J, Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V, Benn, Caroline L, Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A, Hayden, Michael R, Khalili-Shirazi, Azadeh, Lowdell, Mark W, Brundin, Patrik, Bates, Gillian P, Leavitt, Blair R, Möller, Thomas, Tabrizi, Sarah J

“…Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral…”
Get full text

Operationalizing compensation over time in neurodegenerative disease by Gregory, Sarah, Long, Jeffrey D, Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Papoutsi, Marina, Mills, James A, Durr, Alexandra, Leavitt, Blair R, Roos, Raymund A C, Stout, Julie C, Scahill, Rachael I, Langbehn, Douglas R, Tabrizi, Sarah J, Rees, Geraint

“…In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al …”
Get full text

Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes by McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., Justo, D., Lehericy, S., Nigaud, K., Valabrègue, R., Schoonderbeek, A., ‘t Hart, E.P., Moss, D. J. Hensman, Ghosh, R., Crawford, H., Papoutsi, M., Berna, C., Mahaleskshmi, D., Reilmann, R., Weber, N., Labuschagne, I., Stout, J., Landwehrmeyer, B., Orth, M., Mayer, I., Johnson, H., Crawfurd, D.

“…The earliest white matter changes in Huntington’s disease are seen before disease onset in the premanifest stage around the striatum, within the corpus…”
Get full text

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes by Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah A., Hensman Moss, Davina J., Alshammari, Asma M., Flower, Michael D., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Holmans, Peter, Jones, Lesley, Langbehn, Douglas R., Kwak, Seung, Tabrizi, Sarah J., Monckton, Darren G.

“…Huntington disease (HD) is caused by an unstable CAG/CAA repeat expansion encoding a toxic polyglutamine tract. Here, we tested the hypotheses that HD outcomes…”
Get full text

Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics by Petkau, Terri L., Life, Benjamin, Lu, Ge, Yang, Jasmine, Fornes, Oriol, Wasserman, Wyeth, Simpson, Elizabeth M., Leavitt, Blair R.

“…The granulin protein (also known as, and hereafter referred to as, progranulin) is a secreted glycoprotein that contributes to overall brain health…”
Get full text

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation by Petkau, Terri L, Kosior, Natalia, de Asis, Kathleen, Connolly, Colúm, Leavitt, Blair R

“…Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while…”
Get full text

Synaptic dysfunction in progranulin-deficient mice by Petkau, Terri L, Neal, Scott J, Milnerwood, Austen, Mew, Ada, Hill, Austin M, Orban, Paul, Gregg, Jenny, Lu, Ge, Feldman, Howard H, Mackenzie, Ian R.A, Raymond, Lynn A, Leavitt, Blair R

“…Abstract Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia (FTD), but the role of progranulin in the brain is poorly…”
Get full text