Search Results - "Leaver, H A"

Therapeutic implications of disorders of cell death signalling: membranes, micro‐environment, and eicosanoid and docosanoid metabolism by Davidson, J, Rotondo, D, Rizzo, MT, Leaver, HA

“…Disruptions of cell death signalling occur in pathological processes, such as cancer and degenerative disease. Increased knowledge of cell death signalling has…”
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Acute phase responses following minimal access and conventional thoracic surgery by Craig, S.R., Leaver, H.A., Yap, P.L., Pugh, G.C., Walker, W.S.

“…Objectives: Major thoracic surgery is associated with trauma-related immunological changes. These may impair anti-tumour immunity. We hypothesize that the…”
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Lymphocyte responses following open and minimally invasive thoracic surgery by LEAVER, H. A, CRAIG, S. R, YAP, P. L, WALKER, W. S

“…Background Immunosuppression associated with surgery may predispose to increased tumour growth or recurrence. Lymphocytes are central components of the immune…”
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The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems by Bell, H. S., Whittle, I. R., Walker, M., Leaver, H. A., Wharton, S. B.

“…Cell death in gliomas may occur either by apoptosis, or, in the case of high grade tumours, by necrosis, but questions remain as to the pathogenesis and…”
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Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology by Leaver, H.A., Wharton, S.B., Bell, H.S., Leaver-Yap, I.M.M., Whittle, I.R.

“…Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour agents. HUFAs act as intracellular signalling molecules in cell proliferation and…”
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Calcium-sensitive mitochondrial membrane potential in human platelets and intrinsic signals of cell death by Leaver, H. A., Schou, A. C., Rizzo, M. T., Prowse, C. V.

“…The mechanisms involved in storage-induced damage in platelets are not well understood, but membrane signalling via Ca2+ ion flux may affect mitochondrial H+…”
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Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma by Leaver, H.A., Bell, H.S., Rizzo, M.T., Ironside, J.W., Gregor, A., Wharton, S.B., Whittle, I.R.

“…The highly unsaturated fatty acids (HUFA) of the n-6 and n-3 series are involved in cell signalling in normal and transformed cells and have recently been…”
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Intracellular oxidation by human glioma cell populations: effect of arachidonic acid by Leaver, H.A., Williams, J.R., Smith, C., Whittle, I.R.

“…Arachidonic acid (AA) and Gamma linolenic acid have been shown to limit glioma cell growth, stimulate apoptosis and lipid peroxidation. However, brain tumours…”
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Apoptosis in human primary brain tumours: actions of arachidonic acid by Williams, J.R., Leaver, H.A., Ironside, J.W., Miller, E.P., Whittle, I.R., Gregor, A.

“…It has been postulated that loss of proliferative control in tumour cells is a consequence of depletion of cellular arachidonic acid (AA) and that exogenous AA…”
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Antitumour actions of highly unsaturated fatty acids: cell signalling and apoptosis by Leaver, H.A., Rizzo, M.T., Whittle, I.R.

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Arachidonic acid induces mobilization of calcium stores and c-jun gene expression: evidence that intracellular calcium release is associated with c-jun activation by Rizzo, M.T., Leaver, A.H., Yu, W.M., Kovacs, R.J.

“…Arachidonic acid (AA) plays a signaling role in the induction of several genes. We previously demonstrated that AA induces c-jun gene expression in the stromal…”
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Effects of N-6 essential fatty acids on glioma invasion and growth : experimental studies with glioma spheroids in collagen gels by BELL, H. S, WHARTON, S. B, LEAVER, H. A, WHITTLE, I. R

“…Intracranial infusions of gamma-linolenic acid (GLA), an essential fatty acid, have been used as an adjuvant therapy following malignant glioma resection;…”
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Prions: Properties, Occurrence, Modes of Transmission and Relevance for Blood Transfusion and Blood Derivatives by Yap, P.L., Leaver, H.A., Gillon, J.

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Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects by LEAVER, H. A, WILLIAMS, J. R, IRONSIDE, J. W, MILLER, E. P, GREGOR, A, SU, B. H, PRESCOTT, R. J, WHITTLE, I. R

“…Background Reactive oxygen intermediates (ROIs) are important signals controlling cell growth and cell death. Local essential fatty acid (EFA) deficiencies in…”
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Apoptosis in human primary brain tumours by A. Leaver, H., Whittle, I. R., Wharton, S. B., Ironside, J. W.

“…Apoptosis, or programmed cell death, has been recognized for nearly three decades as occurring in many organs in response to different pathophysiological…”
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Effect of blood transfusion on survival after esophagogastrectomy for carcinoma by Craig, Stewart R, Adam, Donald J, Yap, Peng Lee, Leaver, H.Anne, Elton, Robert A, Cameron, Evan W.J, Sang, Christopher T.M, Walker, William S

“…Background. There is growing evidence that blood transfusion is associated with clinical factors that can lead to transfusion-induced immunosuppression. This…”
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Peroxides in human leucocytes in acute septic shock: a preliminary study of acute phase changes and mortality by Leaver, H A, Yap, P L, Rogers, P, Wright, I, Smith, G, Williams, P E, France, A J, Craig, S R, Walker, W S, Prescott, R J

“…Peroxidation by peripheral blood leucocytes was measured in 15 patients in acute septic shock and 15 uninfected controls, using the probe dichloroflorescein…”
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The biosynthesis of the 3-series prostaglandins in rat uterus after alpha-linolenic acid feeding: mass spectroscopy of prostaglandins E and F produced by rat uteri in tissue culture by Leaver, H A, Howie, A, Wilson, N H

“…The abnormal uterine activity associated with dietary n-3 fatty acids may result from competitive inhibition of PG2 production. Uterine synthesis of 2- and…”
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The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition by Howie, A, Leaver, H A, Wilson, N H, Yap, P L, Aitken, I D

“…The effect of dietary fatty acids on uterine fatty acid composition was studied in rats fed control diet or semi-synthetic diet supplemented with 1.5…”
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Apoptosis and the Dynamics of Infection and Disease by Leaver, H.A., Brock, J.H.

“…Progress in defining the pathways of apoptosis has given new insights into cell dynamics in the immune system. The importance of apoptosis in clonal selection…”
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