Search Results - "Leavens, W. J."

The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma by Ayrton, J., Dear, G. J., Leavens, W. J., Mallett, D. N., Plumb, R. S.

“…The use of turbulent flow chromatography coupled to mass spectrometry (turbulent flow LC/MS) shows great potential for the rapid, direct analysis of…”
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Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma by Ayrton, J, Dear, G.J, Leavens, W.J, Mallett, D.N, Plumb, R.S

“…The use of ultra-high flow-rate chromatography coupled to mass spectrometry offers great potential for the rapid, on-line analysis of pharmaceutical compounds…”
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Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates by Ayrton, J., Plumb, R., Leavens, W. J., Mallett, D., Dickins, M., Dear, G. J.

“…A liquid chromatography tandem mass spectrometry (LC/MS/MS) method has been developed for the fast routine analysis of selected CYP450 probe substrate…”
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The absolute bioavailability and metabolic disposition of the novel antimigraine compound zolmitriptan (311C90) by Seaber, E., On, N., Dixon, R. M., Gibbens, M., Leavens, W. J., Liptrot, J., Chittick, G., Posner, J., Rolan†, P. E., Peck, R. W.

“…Aims Two open studies in healthy volunteers were conducted to determine the absolute bioavailability and metabolic disposition of zolmitriptan (311C90), a…”
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Use of generic fast gradient liquid chromatography–tandem mass spectroscopy in quantitative bioanalysis by Ayrton, J., Dear, G.J., Leavens, W.J., Mallett, D.N., Plumb, R.S.

“…Short narrow analytical HPLC columns have been used successfully with high linear flow-rates and combined with mass spectrometric detection to produce a…”
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Analysis of 5-(4-acetamidophenyl)pyrazin-2(1H)-one (SK&F 94120) in plasma with an Analytichem automated sample processor liquid chromatography module by Pearce, J C, Jelly, J A, Fernandes, K A, Leavens, W J, McDowall, R D

“…A selective and specific assay for 5-(4-acetamidophenyl)pyrazin-2(1H)-one (SK&F 94120), a novel inotropic agent, has been developed. The method incorporates a…”
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Analysis of 2-cyano-1-methyl-3-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl phenyl]guanidine in dog plasma by liquid-solid extraction and reversed-phase high-performance liquid chromatography by Pearce, J C, Leavens, W J, McDowall, R D

“…A method for the determination of 2-cyano-1-methyl-3-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin- 3- yl)phenyl]guanidine (SK&F94836, 1) in plasma is…”
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Characterization of calf brain dopamine receptors by Leavens, W.J, Riddall, D.R

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Affinities of drugs for the agonist and antagonist states of the dopamine receptor by Riddall, D R, Leavens, W J

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Derivatization for liquid chromatography/electrospray mass spectrometry: synthesis of tris(trimethoxyphenyl)phosphonium compounds and their derivatives of amine and carboxylic acids by Leavens, William J, Lane, Stephen J, Carr, Richard M, Lockie, Andrea M, Waterhouse, Ian

“…A simple method for the derivatization of primary amines and carboxylic acids with tris(trimethoxyphenyl)phosphonium (TMPP) reagents to enhance their detection…”
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Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives by Barry, Samantha J., Carr, Richard M., Lane, Stephen J., Leavens, William J., Monté, Soraya, Waterhouse, Ian

“…A simple method has been developed for the pre‐column derivatisation of low molecular weight primary and secondary amines and carboxylic acids using quaternary…”
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