Search Results - "Leary, Glenn"

Preclinical Development of Edit-201, a Multigene Edited Healthy Donor NK Cell with Enhanced Anti-Tumor Function and Superior Serial Killing Activity in an Immunosuppressive Environment by Borges, Christopher M, Wasko, Kevin, Nasser, Jared M, Donahue, Kelly, Pfautz, Amanda, Antony, Lincy P, Leary, Glenn, Sexton, Steven, Morgan, Richard A., Wong, Karrie K

“…Natural killer (NK) cells distinguish tumor from healthy tissue via multiple mechanisms, including recognition of stress ligands and loss of MHC class I…”
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Abstract 5512: CBLB, CISH and CD70 multiplexed gene knockout with CRISPR/Cas9 enhances cytotoxicity of CD70-CAR NK cells and provides greater resistance to TGF-β for cancer immunotherapy by Guo, Chao, Fan, Yanying, Aronov, Alexander, Zhang, Qi, Sahu, Sombeet, Dequéant, Mary-Lee, Guo, Changan, Karnik, Sushant, Leary, Glenn D., Massilamany, Chandirasegaran, Chan, Ivan H., Trager, James B.

“…Abstract Natural killer (NK) cells provide an attractive platform for development of effective cancer immunotherapies. NK cells are known for their ability to…”
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Design of Network-on-Chip Architectures With a Genetic Algorithm-Based Technique by Leary, G., Srinivasan, K., Mehta, K., Chatha, K.S.

“…The network-on-chip (NoC) design problem requires the generation of a power and resource efficient interconnection architecture that can support the…”
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Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors by Terrett, Jonathan A., Kalaitzidis, Demetrios, Dequeant, Mary-Lee, Karnik, Sushant, Ghonime, Mohammed, Guo, Changan, Chain, Robert, Heath, Heidi, Jaishankar, Nivedita, Yuen, Rachel, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Massilamany, Chandirasegaran, McEwan, Brigid, Leary, Glenn, Dar, Henia, Ferulo, Daniel, Allen, Melanie, Tipton, Kimberley, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat D., Tang, Yin, Chaudhari, Hemangi, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Koch, Elizabeth, Dunn, Andrew, Sula, Erisa, Waldman, Jacob, Loaiza, Cristian, Zhang, Maria Lei, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Benton, Mark, Ma, Anna, Cohen, Sarah, Weaver, Annie, Finch, Christopher, Morrow, Phuong Khanh

“…Abstract Allo CAR T cells represent an “off-the-shelf” treatment option that addresses the unmet need for immediately available, potentially curative…”
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145 Preclinical development of EDIT-201, a multiplexed CRISPR-Cas12a gene edited healthy donor derived NK cells demonstrating improved persistence and resistance to the tumor microenvironment by Wong, Karrie, Sexton, Steven, Donahue, Kelly, Lincy Prem Antony, Wasko, Kevin, Nasser, Jared, Leary, Glenn, Pfautz, Amanda, Porth, Owen, Pierce, William, Sousa, Patricia, Scott, Sean, Wilson, Aaron, Chang, Kai-Hsin, Zuris, John, Wilson, Christopher, Morgan, Richard, Borges, Christopher

“…BackgroundNatural killer (NK) cells distinguish tumor from healthy tissue via multiple mechanisms, including recognition of stress ligands and loss of MHC…”
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System-Level Synthesis of Dataplane Subsystems for MPSoCs by Leary, Glenn

“…In recent years we have witnessed a shift towards multi-processor system-on-chips (MPSoCs) to address the demands of embedded devices (such as cell phones, GPS…”
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System-level synthesis of memory architecture for stream processing sub-systems of a MPSoC by Leary, Glenn, Che, Weijia, Chatha, Karam S.

“…Many embedded processor chips aimed at high performance and low power application domains are implemented as multiprocessor System-on-Chip (MPSoC) devices. The…”
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Design of NoC for SoC with Multiple Use Cases Requiring Guaranteed Performance by Leary, G., Chatha, K.S.

“…Many SoC architectures aimed at the multimedia domain support multiple use cases where only a subset of the applications is active at any time. Further, each…”
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System-Level Synthesis of Dataplane Subsystems for MPSoCs by Leary, Glenn

“…In recent years we have witnessed a shift towards multi-processor system-on-chips (MPSoCs) to address the demands of embedded devices (such as cell phones, GPS…”
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A holistic approach to network-on-chip synthesis by Leary, Glenn, Chatha, Karam S.

“…Application specific Network-on-Chip (NoC) architectures have emerged as a leading technology to address the communication woes of multi-processor…”
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Performance and resource optimization of NoC router architecture for master and slave IP cores by Leary, Glenn, Mehta, Krishna, Chatha, Karam S.

“…System-on-Chip architectures incorporate several IP cores with well defined master and slave characteristics in terms of on-chip communication. The paper…”
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