Search Results - "Learned, Marc R."

Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis by Zhou, Mei, Yang, Hong, Learned, R. Marc, Tian, Hui, Ling, Lei

“…Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is the second leading cause of cancer mortality worldwide. Fibroblast Growth Factor 19 (…”
Get full text

FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis by DePaoli, Alex M, Zhou, Mei, Kaplan, Daniel D, Hunt, Steven C, Adams, Ted D, Learned, R Marc, Tian, Hui, Ling, Lei

“…Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast…”
Get full text

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis[S] by Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., Tian, Hui, DePaoli, Alex M., Ling, Lei

“…Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19…”
Get full text

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19 by MEI ZHOU, XUEYAN WANG, LEARNED, R. Marc, DEPAOLI, Alex M, HUI TIAN, LEI LING, VAN PHUNG, LINDHOUT, Darrin A, MONDAL, Kalyani, HSU, Jer-Yuan, HONG YANG, HUMPHREY, Mark, XUNSHAN DING, ARORA, Taruna

“…Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related death, develops from premalignant lesions in chronically damaged livers. Although…”
Get full text

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15 by Zhou, Mei, Luo, Jian, Chen, Michael, Yang, Hong, Learned, R. Marc, DePaoli, Alex M, Tian, Hui, Ling, Lei

“…Graphical abstract…”
Get full text

A nontumorigenic variant of FGF19 treats cholestatic liver diseases by Luo, Jian, Ko, Brian, Elliott, Michael, Zhou, Mei, Lindhout, Darrin A, Phung, Van, To, Carmen, Learned, R Marc, Tian, Hui, DePaoli, Alex M, Ling, Lei

“…Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may…”
Get more information

Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice by Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., DePaoli, Alex M., Tian, Hui, Ling, Lei

“…Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive…”
Get full text

T0070907, a Selective Ligand for Peroxisome Proliferator-activated Receptor γ, Functions as an Antagonist of Biochemical and Cellular Activities by Lee, Gary, Elwood, Fabienne, McNally, John, Weiszmann, Jennifer, Lindstrom, Michelle, Amaral, Kate, Nakamura, Motonao, Miao, Shichang, Cao, Ping, Learned, R. Marc, Chen, Jin-Long, Li, Yang

“…The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ (NR1C3)) plays a central role in adipogenesis and is the molecular target for…”
Get full text

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2‐deficient mice by Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., DePaoli, Alex M., Tian, Hui, Ling, Lei

“…Defects in multidrug resistance 3 gene (MDR3), which encodes the canalicular phospholipid flippase, cause a wide spectrum of cholangiopathy phenotypes in…”
Get full text

INT131: A Selective Modulator of PPARγ by Motani, Alykhan, Wang, Zhulun, Weiszmann, Jennifer, McGee, Lawrence R., Lee, Gary, Liu, Qingxiang, Staunton, Jocelyn, Fang, Zexu, Fuentes, Helen, Lindstrom, Michelle, Liu, Jinsong, Biermann, Donna H.T., Jaen, Juan, Walker, Nigel P.C., Learned, R. Marc, Chen, Jin-Long, Li, Yang

“…The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ; NR1C3) plays a central role in adipogenesis and is the molecular target of…”
Get full text

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties by Li, Yang, Wang, Zhulun, Furukawa, Noboru, Escaron, Patrick, Weiszmann, Jennifer, Lee, Gary, Lindstrom, Michelle, Liu, Jinsong, Liu, Xiaohong, Xu, Haoda, Plotnikova, Olga, Prasad, Vidya, Walker, Nigel, Learned, R. Marc, Chen, Jin-Long

“…The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) plays central roles in adipogenesis and glucose homeostasis and is the…”
Get full text

Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity by Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

“…PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of…”
Get full text

Identification of a Nuclear Receptor for Bile Acids by Makishima, Makoto, Okamoto, Arthur Y., Repa, Joyce J., Tu, Hua, Learned, R. Marc, Luk, Alvin, Hull, Mitchell V., Lustig, Kevin D., Mangelsdorf, David J., Shan, Bei

“…Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here…”
Get full text

Functional Cooperativity between Transcription Factors UBF1 and SL1 Mediates Human Ribosomal RNA Synthesis by Bell, Stephen P., Learned, R. Marc, Jantzen, Hans-Michael, Tjian, Robert

“…The human ribosomal RNA promoter contains two distinct control elements (UCE and core) both of which are recognized by the sequence-specific DNA binding…”
Get full text

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells by Medina, Julio C., Shan, Bei, Beckmann, Holger, Farrell, Robert P., Clark, David L., Marc Learned, R., Roche, Daniel, Li, Angela, Baichwal, Vijay, Case, Casey, Baeuerle, Patrick A., Rosen, Terry, Jaen, Juan C.

“…A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against…”
Get full text

Light modulates the spatial patterns of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase gene expression in Arabidopsis thaliana by Learned, R. Marc, Connolly, Erin L.

“…Summary Although the coordinated biosynthesis of isoprenoid compounds is thought to be essential to the normal processes of plant growth and development, the…”
Get full text

Co‐expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis by Re, Edward B., Jones, Daniel, Learned, R. Marc

“…In eukaryotes, all isoprenoid compounds share a common precursor, mevalonic acid, whose synthesis is catalyzed by the enzyme 3‐hydroxy‐3‐methylglutaryl…”
Get full text

Discovery of INT131: A selective PPAR[gamma] modulator that enhances insulin sensitivity by Taygerly, Joshua P, McGee, Lawrence R, Rubenstein, Steven M, Houze, Jonathan B, Cushing, Timothy D, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R, Jaen, Juan, Miao, Shichang, Timmermans, Pieter B, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

“…PPAR[gamma] is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the…”
Get full text

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties by Yang Li, Zhulun Wang, Noboru Furukawa, Patrick Escaron, Jennifer Weiszmann, Gary Lee, Michelle Lindstrom, Jinsong Liu, Xiaohong Liu, Haoda Xu, Olga Plotnikova, Vidya Prasad, Nigel Walker, R. Marc Learned, Jin-Long Chen

“…The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) plays central roles in adipogenesis and glucose homeostasis and is the…”
Get full text

Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells by Medina, Julio C., Roche, Daniel, Shan, Bei, Learned, R.Marc, Frankmoelle, Walter P., Clark, David L., Rosen, Terry, Jaen, Juan C.

“…In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR…”
Get full text