Search Results - "Leandro, Maria J"

The lung in a cohort of rheumatoid arthritis patients—an overview of different types of involvement and treatment by Duarte, Ana C, Porter, Joanna C, Leandro, Maria J

“…Abstract Objectives Lung involvement in RA has several manifestations and is a major cause of morbidity and mortality. The aim of this study was to…”
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CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Mensah, Fane F K, Armstrong, Christopher W, Reddy, Venkat, Bansal, Amolak S, Berkovitz, Saul, Leandro, Maria J, Cambridge, Geraldine

“…CD24 expression on pro-B cells plays a role in B cell selection and development in the bone marrow. We previously detected higher CD24 expression and frequency…”
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In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS by Armstrong, Christopher W, Mensah, Fane F K, Leandro, Maria J, Reddy, Venkat, Gooley, Paul R, Berkovitz, Saul, Cambridge, Geraldine

“…Disturbances of energy metabolism contribute to the clinical manifestations of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Previously, we…”
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Expression of B cell activating factor (BAFF) and BAFF-binding receptors in rheumatoid arthritis by Leandro, Maria J, Cambridge, Geraldine

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B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies by Leandro, Maria J

“…In humans, different B-cell subpopulations can be distinguished in peripheral blood and other tissues on the basis of differential expression of various…”
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B-cell therapies in established rheumatoid arthritis by Leandro, Maria J., MD, PhD, Becerra-Fernandez, Elena, MD

“…B-cell depletion therapy based on rituximab is effective and relatively safe in established rheumatoid arthritis. Rituximab is licensed for the treatment of…”
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A retrospective seven‐year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients by Lu, Tim Y.‐T., Ng, Kristine P., Cambridge, Geraldine, Leandro, Maria J., Edwards, Jonathan C. W., Ehrenstein, Michael, Isenberg, David A.

“…Objective To describe the 6‐month clinical outcome and the long‐term safety profile of B cell depletion therapy (BCDT) in 50 patients with active systemic…”
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Infections Related to Biologics: Agents Targeting B Cells by Leandro, Maria J

“…B cells are an essential component of the adaptive immune system. Since the late 1990s biologic drugs targeting B cells have been used to treat not only…”
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Expression of the inherently autoreactive idiotope 9G4 on autoantibodies to citrullinated peptides and on rheumatoid factors in patients with early and established rheumatoid arthritis by Cambridge, Geraldine, Moura, Rita, Santos, Tania, Khawaja, Akif A., Polido Pereira, Joaquim, Canhao, Helena, Leandro, Maria J., Fonseca, João

“…Copyright: © 2014 Cambridge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits…”
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Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples by Reddy, Venkat, Klein, Christian, Isenberg, David A, Glennie, Martin J, Cambridge, Geraldine, Cragg, Mark S, Leandro, Maria J

“…A proportion of RA and SLE patients treated with standard doses of rituximab (RTX) display inefficient B cell deletion and poor clinical responses that can be…”
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Pragmatic Treatment of Patients With Systemic Lupus Erythematosus With Rituximab: Long‐Term Effects on Serum Immunoglobulins by Reddy, Venkat, Martinez, Lina, Isenberg, David A., Leandro, Maria J., Cambridge, Geraldine

“…Objective B cell–depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with systemic lupus erythematosus (SLE). The…”
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Disparity in peripheral and renal B-cell depletion with rituximab in systemic lupus erythematosus: an opportunity for obinutuzumab? by Reddy, Venkat R, Pepper, Ruth J, Shah, Kavina, Cambridge, Geraldine, Henderson, Scott R, Klein, Christian, Kell, Loren, Taylor, Samuel J, Isenberg, David A, Cragg, Mark S, Leandro, Maria J

“…Abstract Objectives To investigate key factors that may contribute to the variability of rituximab-mediated peripheral and renal B cell depletion (BCD) in SLE…”
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Total serum immunoglobulin levels in patients with RA after multiple B-cell depletion cycles based on rituximab: relationship with B-cell kinetics by DE LA TORRE, Inmaculada, LEANDRO, Maria J, VALOR, Lara, BECERRA, Elena, EDWARDS, Jonathan C. W, CAMBRIDGE, Geraldine

“…To investigate whether the incidence of secondary hypogammaglobulinaemia in patients with RA following rituximab was related to patterns of B-cell return and…”
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Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study by Lima, Jorge, Martins, Catarina, Leandro, Maria J, Nunes, Glória, Sousa, Maria-José, Branco, Jorge C, Borrego, Luís-Miguel

“…B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory)…”
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B cell depletion with rituximab in patients with rheumatoid arthritis: Multiplex bead array reveals the kinetics of IgG and IgA antibodies to citrullinated antigens by Cambridge, Geraldine, Leandro, Maria J, Lahey, Lauren J, Fairhead, Thomas, Robinson, William H, Sokolove, Jeremy

“…Abstract The serology of patients with Rheumatoid arthritis (RA) is characterized by persistently raised levels of autoantibodies: Rheumatoid Factors (RhF)…”
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B cell depletion therapy in systemic lupus erythematosus: long-term follow-up and predictors of response by Ng, Kristine P, Cambridge, Geraldine, Leandro, Maria J, Edwards, Jonathan C W, Ehrenstein, Michael, Isenberg, David A

“…Objectives: To describe the long-term clinical outcome and safety profile of B cell depletion therapy (BCDT) in patients with systemic lupus erythematosus…”
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Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB by Stopforth, Richard J, Oldham, Robert J, Tutt, Alison L, Duriez, Patrick, Chan, H T Claude, Binkowski, Brock F, Zimprich, Chad, Li, Dun, Hargreaves, Philip G, Cong, Mei, Reddy, Venkat, Leandro, Maria J, Cambridge, Geraldine, Lux, Anja, Nimmerjahn, Falk, Cragg, Mark S

“…Fc γ receptors (FcγR) are involved in multiple aspects of immune cell regulation, are central to the success of mAb therapeutics, and underpin the pathology of…”
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B-cell-activating factor receptor expression on naive and memory B cells: relationship with relapse in patients with rheumatoid arthritis following B-cell depletion therapy by de la Torre, Inmaculada, Moura, Rita A, Leandro, Maria J, Edwards, Jonathan, Cambridge, Geraldine

“…To examine the expression of B-cell-activating factor receptor (BAFF-R) on naive CD27- and memory CD27+ B cells in normal individuals and patients with…”
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B lymphocyte depletion in rheumatoid arthritis: targeting of CD20 by Edwards, Jonathan C W, Leandro, Maria J, Cambridge, Geraldine

“…During the 1990s evidence emerged to suggest that B lymphocyte depletion in rheumatoid arthritis (RA) might be of major benefit. In 1997 the B lympholytic…”
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Juvenile arthritis disease activity score is a better reflector of active disease than the disease activity score 28 in adults with polyarticular juvenile idiopathic arthritis by Wu, Qiong, Chaplin, Hema, Ambrose, Nicola, Sen, Debajit, Leandro, Maria J, Wing, Charlotte, Daly, Nicola, Webb, Kate, Fisher, Corinne, Suffield, Linda, Josephs, Francesca, Pilkington, Clarissa, Eleftheriou, Despina, Al-Obaidi, Muthana, Compeyrot-Lacassagne, Sandrine, Wedderburn, Lucy R, Ioannou, Yiannis

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