Search Results - "Leandro, Giovana S."

Autophagy Roles in the Modulation of DNA Repair Pathways by Gomes, Luciana R, Menck, Carlos F M, Leandro, Giovana S

“…Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders…”
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Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes by Leandro, Giovana S, Lobo, Romulo R, Oliveira, Douglas V N P, Moriguti, Julio C, Sakamoto-Hojo, Elza T

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by loss of memory and cognitive capacity. Given the limitations to analyze…”
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DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes by Sykora, Peter, Misiak, Magdalena, Wang, Yue, Ghosh, Somnath, Leandro, Giovana S, Liu, Dong, Tian, Jane, Baptiste, Beverly A, Cong, Wei-Na, Brenerman, Boris M, Fang, Evandro, Becker, Kevin G, Hamilton, Royce J, Chigurupati, Soumya, Zhang, Yongqing, Egan, Josephine M, Croteau, Deborah L, Wilson, 3rd, David M, Mattson, Mark P, Bohr, Vilhelm A

“…We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model. The new model is a cross of a common…”
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The impact of base excision DNA repair in age-related neurodegenerative diseases by Leandro, Giovana S, Sykora, Peter, Bohr, Vilhelm A

“…The aging process and several age-related neurodegenerative disorders have been linked to elevated levels of DNA damage induced by ROS and deficiency in DNA…”
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DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide by Latancia, Marcela T., Moreno, Natália C., Leandro, Giovana S., Ribeiro, Victoria Chaves, de Souza, Izadora, Vieira, William Kleber Martins, Bastos, André Uchimura, Hoch, Nicolas Carlos, Rocha, Clarissa R.R., Menck, Carlos F.M.

“…Human DNA polymerases can bypass DNA lesions performing translesion synthesis (TLS), a mechanism of DNA damage tolerance. Tumor cells use this mechanism to…”
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E2F transcription factors associated with up-regulated genes in glioblastoma by Donaires, Flávia S, Godoy, Paulo R D V, Leandro, Giovana S, Puthier, Denis, Sakamoto-Hojo, Elza T

“…Glioblastoma is considered to the most common and malignant brain tumor in adults. Patients have a median survival of approximately one year from diagnosis due…”
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