Search Results - "Lean, Fabian Z. X"

Temperate conditions restrict Japanese encephalitis virus infection to the mid-gut and prevents systemic dissemination in Culex pipiens mosquitoes by Folly, Arran J., Dorey-Robinson, Daniel, Hernández-Triana, Luis M., Ackroyd, Stuart, Vidana, Beatriz, Lean, Fabian Z. X., Hicks, Daniel, Nuñez, Alejandro, Johnson, Nicholas

“…Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the main cause of viral encephalitis in Asia. However, with changing climate JEV has the…”
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Detection of Highly Pathogenic Avian Influenza Virus H5N1 Clade 2.3.4.4b in Great Skuas: A Species of Conservation Concern in Great Britain by Banyard, Ashley C, Lean, Fabian Z X, Robinson, Caroline, Howie, Fiona, Tyler, Glen, Nisbet, Craig, Seekings, James, Meyer, Stephanie, Whittard, Elliot, Ashpitel, Henry F, Bas, Mehmet, Byrne, Alexander M P, Lewis, Tom, James, Joe, Stephan, Levon, Lewis, Nicola S, Brown, Ian H, Hansen, Rowena D E, Reid, Scott M

“…The UK and Europe have seen successive outbreaks of highly pathogenic avian influenza across the 2020/21 and 2021/22 autumn/winter seasons. Understanding both…”
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Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens by Lean, Fabian Z. X., Lamers, Mart M., Smith, Samuel P., Shipley, Rebecca, Schipper, Debby, Temperton, Nigel, Haagmans, Bart L., Banyard, Ashley C., Bewley, Kevin R., Carroll, Miles W., Brookes, Sharon M., Brown, Ian, Nuñez, Alejandro

“…The rapid emergence of SARS-CoV-2, the causative agent of COVID-19, and its dissemination globally has caused an unprecedented strain on public health. Animal…”
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Different Outcomes of Chicken Infection with UK-Origin H5N1-2020 and H5N8-2020 High-Pathogenicity Avian Influenza Viruses (Clade 2.3.4.4b) by Seekings, Amanda H, Warren, Caroline J, Thomas, Saumya S, Lean, Fabian Z. X, Selden, David, Mollett, Benjamin C, van Diemen, Pauline M, Banyard, Ashley C, Slomka, Marek J

“…Clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses (HPAIVs) of the “goose/Guangdong” lineage have caused a series of European epizootics since 2014…”
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Comparative evaluation of disease dynamics in wild boar and domestic pigs experimentally inoculated intranasally with the European highly virulent African swine fever virus genotype II strain "Armenia 2007" by Sánchez-Cordón, Pedro J, Lean, Fabian Z X, Batten, Carrie, Steinbach, Falko, Neimanis, Aleksija, Le Potier, Marie-Frédérique, Wikström-Lassa, Emil, Wynne, Felicity, Strong, Rebecca, McCleary, Stephen, Crooke, Helen, Gavier-Widén, Dolores, Núñez, Alejandro

“…Since the reintroduction of African swine fever virus (ASFV) in Europe in 2007 and its subsequent spread to Asia, wild boar has played a crucial role in…”
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Evaluating the Impact of Low-Pathogenicity Avian Influenza H6N1 Outbreaks in United Kingdom and Republic of Ireland Poultry Farms during 2020 by McMenamy, Michael J, McKenna, Robyn, Bailie, Valerie B, Cunningham, Ben, Jeffers, Adam, McCullough, Kelly, Forsythe, Catherine, Cuartero, Laura Garza, Flynn, Orla, Byrne, Christina, Connaghan, Emily, Moriarty, John, Fanning, June, Ronan, Stephanie, Barrett, Damien, Fusaro, Alice, Monne, Isabella, Terregino, Calogero, James, Joe, Byrne, Alexander M P, Lean, Fabian Z X, Núñez, Alejandro, Reid, Scott M, Hansen, Rowena, Brown, Ian H, Banyard, Ashley C, Lemon, Ken

“…In January 2020, increased mortality was reported in a small broiler breeder flock in County Fermanagh, Northern Ireland. Gross pathological findings included…”
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Detection of SARS-CoV-2 Delta Variant (B.1.617.2) in Domestic Dogs and Zoo Tigers in England and Jersey during 2021 by Seekings, Amanda H, Shipley, Rebecca, Byrne, Alexander M P, Shukla, Shweta, Golding, Megan, Amaya-Cuesta, Joan, Goharriz, Hooman, Vitores, Ana Gómez, Lean, Fabian Z X, James, Joe, Núñez, Alejandro, Breed, Alistair, Frost, Andrew, Balzer, Jörg, Brown, Ian H, Brookes, Sharon M, McElhinney, Lorraine M

“…Reverse zoonotic transmission events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described since the start of the pandemic, and…”
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Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus by Shipley, Rebecca, Wright, Edward, Lean, Fabian Z. X., Selden, David, Horton, Daniel L., Fooks, Anthony R., Banyard, Ashley C.

“…Rabies is a fatal encephalitis caused by an important group of viruses within the Lyssavirus genus. The prototype virus, rabies virus, is still the most…”
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Susceptibility of Aedes albopictus and Culex quinquefasciatus to Japanese encephalitis virus by Hernández-Triana, Luis M, Folly, Arran J, Sewgobind, Sanam, Lean, Fabian Z. X, Ackroyd, Stuart, Nuéez, Alejandro, Delacour, Sarah, Drago, Andrea, Visentin, Patrizia, Mansfield, Karen L, Johnson, Nicholas

“…Japanese encephalitis virus (JEV) is the principal cause of mosquito-borne encephalitis in human populations within Asia. If introduced into new geographic…”
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Incursion of European Bat Lyssavirus 1 (EBLV-1) in Serotine Bats in the United Kingdom by Folly, Arran J, Marston, Denise A, Golding, Megan, Shukla, Shweta, Wilkie, Rebekah, Lean, Fabian Z X, Núñez, Alejandro, Worledge, Lisa, Aegerter, James, Banyard, Ashley C, Fooks, Anthony R, Johnson, Nicholas, McElhinney, Lorraine M

“…Lyssaviruses are an important genus of zoonotic viruses which cause the disease rabies. The United Kingdom is free of classical rabies (RABV). However, bat…”
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Attenuation of Bluetongue Virus (BTV) in an in ovo Model Is Related to the Changes of Viral Genetic Diversity of Cell-Culture Passaged BTV by Lean, Fabian Z X, Neave, Matthew J, White, John R, Payne, Jean, Eastwood, Teresa, Bergfeld, Jemma, Di Rubbo, Antonio, Stevens, Vittoria, Davies, Kelly R, Devlin, Joanne, Williams, David T, Bingham, John

“…The embryonated chicken egg (ECE) is routinely used for the laboratory isolation and adaptation of Bluetongue virus (BTV) in vitro. However, its utility as an…”
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Evaluation of Bluetongue Virus (BTV) Antibodies for the Immunohistochemical Detection of BTV and Other Orbiviruses by Lean, Fabian Z. X., Payne, Jean, Harper, Jennifer, Devlin, Joanne, Williams, David T., Bingham, John

“…The detection of bluetongue virus (BTV) antigens in formalin-fixed tissues has been challenging; therefore, only a limited number of studies on suitable…”
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Gross pathology associated with highly pathogenic avian influenza H5N8 and H5N1 in naturally infected birds in the UK (2020–2021) by Lean, Fabian Z. X., Núñez, Alejandro, Banyard, Ashley C., Reid, Scott M., Brown, Ian H., Hansen, Rowena D. E.

“…Background Multiple outbreaks with highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b viruses, including H5N8 and H5N1, have occurred in the United…”
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Differential susceptibility of SARS‐CoV‐2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation by Lean, Fabian Z. X., Núñez, Alejandro, Spiro, Simon, Priestnall, Simon L., Vreman, Sandra, Bailey, Dalan, James, Joe, Wrigglesworth, Ethan, Suarez‐Bonnet, Alejandro, Conceicao, Carina, Thakur, Nazia, Byrne, Alexander M.P., Ackroyd, Stuart, Delahay, Richard J., Poel, Wim H. M., Brown, Ian H., Fooks, Anthony R., Brookes, Sharon M.

“…Angiotensin converting enzyme 2 (ACE2) is a host cell membrane protein (receptor) that mediates the binding of coronavirus, most notably SARS coronaviruses in…”
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Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection by Everett, Helen E, Lean, Fabian Z X, Byrne, Alexander M P, van Diemen, Pauline M, Rhodes, Shelley, James, Joe, Mollett, Benjamin, Coward, Vivien J, Skinner, Paul, Warren, Caroline J, Bewley, Kevin R, Watson, Samantha, Hurley, Shellene, Ryan, Kathryn A, Hall, Yper, Simmons, Hugh, Núñez, Alejandro, Carroll, Miles W, Brown, Ian H, Brookes, Sharon M

“…Ferrets were experimentally inoculated with SARS-CoV-2 (severe acute respiratory syndrome (SARS)-related coronavirus 2) to assess infection dynamics and host…”
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A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies by McNee, Adam, Vanover, Daryll, Rijal, Pramila, Paudyal, Basudev, Lean, Fabian Z X, MacLoughlin, Ronan, Núñez, Alejandro, Townsend, Alain, Santangelo, Philip J, Tchilian, Elma

“…Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large…”
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In vivo challenge studies on vaccinated chickens indicate a virus genotype mismatched vaccine still offers significant protection against NDV by Mahmood, Sahar, Skinner, Paul, Warren, Caroline J., Mayers, Jo, James, Joe, Núñez, Alejandro, Lean, Fabian Z.X., Brookes, Sharon M., Brown, Ian H., Banyard, Ashley C., Ross, Craig S.

“…•ND vaccines are broadly protective against clinical disease and mortality but do not induce sterilising immunity.•Genotype mismatch alone does not contribute…”
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Porcine Respiratory Coronavirus as a Model for Acute Respiratory Coronavirus Disease by Keep, Sarah, Carr, Brigid Veronica, Lean, Fabian Z X, Fones, Albert, Newman, Joseph, Dowgier, Giulia, Freimanis, Graham, Vatzia, Eleni, Polo, Noemi, Everest, Holly, Webb, Isobel, Mcnee, Adam, Paudyal, Basu, Thakur, Nazia, Nunez, Alejandro, MacLoughlin, Ronan, Maier, Helena, Hammond, John, Bailey, Dalan, Waters, Ryan, Charleston, Bryan, Tuthill, Toby, Britton, Paul, Bickerton, Erica, Tchilian, Elma

“…In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for…”
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Evidence for overwintering and autochthonous transmission of Usutu virus to wild birds following its redetection in the United Kingdom by Folly, Arran J., Sewgobind, Sanam, Hernández‐Triana, Luis M., Mansfield, Karen L., Lean, Fabian Z. X., Lawson, Becki, Seilern‐Moy, Katharina, Cunningham, Andrew A., Spiro, Simon, Wrigglesworth, Ethan, Pearce‐Kelly, Paul, Herdman, Trent, Johnston, Colin, Berrell, Morgan, Vaux, Alexander G. C., Medlock, Jolyon M., Johnson, Nicholas

“…Usutu virus (USUV) is an emerging zoonotic arbovirus in Europe, where it primarily impacts Eurasian blackbirds (Turdus merula). For mosquito‐borne viruses to…”
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Combining host and vector data informs emergence and potential impact of an Usutu virus outbreak in UK wild birds by Lawson, Becki, Robinson, Robert A., Briscoe, Andrew G., Cunningham, Andrew A., Fooks, Anthony R., Heaver, Joseph P., Hernández-Triana, Luis M., John, Shinto K., Johnson, Nicholas, Johnston, Colin, Lean, Fabian Z. X., Macgregor, Shaheed K., Masters, Nicholas J., McCracken, Fiona, McElhinney, Lorraine M., Medlock, Jolyon M., Pearce-Kelly, Paul, Seilern-Moy, Katharina, Spiro, Simon, Vaux, Alexander G. C., Folly, Arran J.

“…Following the first detection in the United Kingdom of Usutu virus (USUV) in wild birds in 2020, we undertook a multidisciplinary investigation that combined…”
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