Search Results - "Leaman, Douglas W"

Genomic and immunogenic changes of Piscine novirhabdovirus (Viral Hemorrhagic Septicemia Virus) over its evolutionary history in the Laurentian Great Lakes by Niner, Megan D, Stepien, Carol A, Gorgoglione, Bartolomeo, Leaman, Douglas W

“…A unique and highly virulent subgenogroup (-IVb) of Piscine novirhabdovirus , also known as Viral Hemorrhagic Septicemia Virus (VHSV), suddenly appeared in the…”
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Effect of the Viral Hemorrhagic Septicemia Virus Nonvirion Protein on Translation via PERK-eIF2α Pathway by Kesterson, Shelby Powell, Ringiesn, Jeffery, Vakharia, Vikram N, Shepherd, Brian S, Leaman, Douglas W, Malathi, Krishnamurthy

“…Viral hemorrhagic septicemia virus (VHSV) is one of the most deadly infectious fish pathogens, posing a serious threat to the aquaculture industry and…”
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Comparative effects of Novirhabdovirus genes on modulating constitutive transcription and innate antiviral responses, in different teleost host cell types by Gorgoglione, Bartolomeo, Ringiesn, Jeffery L, Pham, Loc H, Shepherd, Brian S, Leaman, Douglas W

“…Infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) are highly contagious, pathogenic Novirhabdoviruses affecting fish…”
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Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication by Ramnani, Barkha, Powell, Shelby, Shetty, Adarsh G, Manivannan, Praveen, Hibbard, Brian R, Leaman, Douglas W, Malathi, Krishnamurthy

“…Virus infection activates integrated stress response (ISR) and stress granule (SG) formation and viruses counteract by interfering with SG assembly, suggesting…”
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Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer by Cheriyath, Venugopalan, Leaman, Douglas W, Borden, Ernest C

“…Interferons (IFNs) manifest their cellular functions by regulating expression of target genes known collectively as IFN-stimulated genes (ISGs). The…”
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Ghrelin Modulates Differential Expression of Genes Relevant to Immune Activities and Antimicrobial Peptides in Primary Head Kidney Cells of Rainbow Trout ( Oncorhynchus mykiss ) by Han, Yueh-Chiang, Leaman, Douglas W, Shepherd, Brian S

“…Ghrelin is a peptide hormone/cytokine that regulates metabolic processes and plays essential roles in the immune system. To evaluate the immunomodulatory…”
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Genome-Wide Polysome Profiling Reveals an Inflammation-Responsive Posttranscriptional Operon in Gamma Interferon-Activated Monocytes by Vyas, Keyur, Chaudhuri, Sujan, Leaman, Douglas W., Komar, Anton A., Musiyenko, Alla, Barik, Sailen, Mazumder, Barsanjit

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse by Mohammad, Mohammad K., Morran, Michael, Slotterbeck, Brandon, Leaman, Douglas W., Sun, Yaping, Grafenstein, Hermann von, Hong, Soon-Cheol, McInerney, Marcia F.

“…The expression, responsiveness and regulation of mouse Toll-like receptors (TLRs) in bone marrow-derived macrophages (BM-Ø) were investigated prior to and…”
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Intercellular adhesion molecule-1 augments myoblast adhesion and fusion through homophilic trans-interactions by Pizza, Francis X., Martin, Ryan A., Springer, Evan M., Leffler, Maxwell S., Woelmer, Bryce R., Recker, Isaac J., Leaman, Douglas W.

“…The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic…”
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Gene Diversification of an Emerging Pathogen: A Decade of Mutation in a Novel Fish Viral Hemorrhagic Septicemia (VHS) Substrain since Its First Appearance in the Laurentian Great Lakes by Stepien, Carol A, Pierce, Lindsey R, Leaman, Douglas W, Niner, Megan D, Shepherd, Brian S

“…Viral Hemorrhagic Septicemia virus (VHSv) is an RNA rhabdovirus, which causes one of the world's most serious fish diseases, infecting >80 freshwater and…”
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Overcoming Resistance to Interferon-Induced Apoptosis of Renal Carcinoma and Melanoma Cells by DNA Demethylation by REU, Frederic J, SOO IN BAE, CHERKASSKY, Leonid, LEAMAN, Douglas W, LINDNER, Daniel, BEAULIEU, Normand, MACLEOD, A. Robert, BORDEN, Ernest C

“…Epigenetic editing of gene expression by aberrant methylation of DNA may help tumor cells escape attack from the innate and acquired immune systems. Resistance…”
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Identification of X-linked Inhibitor of Apoptosis-associated Factor-1 as an Interferon-stimulated Gene That Augments TRAIL Apo2L-induced Apoptosis by Leaman, Douglas W, Chawla-Sarkar, Mamta, Vyas, Keyur, Reheman, Monila, Tamai, Katsuyuki, Toji, Singo, Borden, Ernest C

“…In the course of gene array studies aimed at identifying IFN-stimulated genes associated with interferon β (IFN-β)-induced apoptosis, we identified X-linked…”
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Involvement of Noxa in Cellular Apoptotic Responses to Interferon, Double-stranded RNA, and Virus Infection by Sun, Yaping, Leaman, Douglas W.

“…Double-stranded RNA (dsRNA) accumulates in virally infected cells, leading to induction of genes encoding proteins involved in signaling, apoptosis, protein…”
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X‐linked inhibitor of apoptosis‐associated factor 1 regulates TNF receptor 1 complex stability by Lin, Boren, Xu, Da, Leaman, Douglas W.

“…X‐linked inhibitor of apoptosis (XIAP)‐associated factor 1 (XAF1) is a cytokine‐regulated, tumor necrosis factor (TNF) receptor‐associated factor (TRAF)…”
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Regulation of RANKL‐induced osteoclastogenesis by RING finger protein RNF114 by Lin, Boren, Ke, Qi, Leaman, Douglas W., Goel, Vijay, Agarwal, Anand

“…ABSTRACT Normal bone remodeling is a continuous process orchestrated by bone‐resorbing osteoclasts and bone‐forming osteoblasts, which an imbalance in bone…”
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Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription by Ke, Qi, Weaver, Wade, Pore, Adam, Gorgoglione, Bartolomeo, Wildschutte, Julia Halo, Xiao, Peng, Shepherd, Brian S, Spear, Allyn, Malathi, Krishnamurthy, Stepien, Carol A, Vakharia, Vikram N, Leaman, Douglas W

“…Viral hemorrhagic septicemia virus (VHSV) is a pathogenic fish rhabdovirus found in discrete locales throughout the Northern Hemisphere. VHSV infection of fish…”
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Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a by Rosebeck, Shaun, Leaman, Douglas W.

“…ISG12a is one of the most highly induced genes following treatment of cells with type I interferons (IFNs). The encoded protein belongs to a family of poorly…”
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Withdrawal: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice by Sarkar, Sagartirtha, Leaman, Douglas W., Gupta, Sudhiranjan, Sil, Parames, Young, David, Morehead, Annitta, Mukherjee, Debabrata, Ratliff, Norman, Sun, Yaping, Rayborn, Mary, Hollyfield, Joe, Sen, Subha

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Expression of Concern: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice by Sarkar, Sagartirtha, Leaman, Douglas W., Gupta, Sudhiranjan, Sil, Parames, Young, David, Morehead, Annitta, Mukherjee, Debabrata, Ratliff, Norman, Sun, Yaping, Rayborn, Mary, Hollyfield, Joe, Sen, Subha

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Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114 by Lin, Boren, Ke, Qi, Li, Haiying, Pheifer, Nichole S., Velliquette, David C., Leaman, Douglas W.

“…•RNF114 inhibited cellular dsRNA responses and RLH-mediated IFN production.•RNF114 is an E3 ubiquitin ligase targeting MAVS for proteasomal degradation.•RNF114…”
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