Search Results - "Leaman, Daniel P"

Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice by Mangala Prasad, Vidya, Leaman, Daniel P., Lovendahl, Klaus N., Croft, Jacob T., Benhaim, Mark A., Hodge, Edgar A., Zwick, Michael B., Lee, Kelly K.

“…HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion…”
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Increased functional stability and homogeneity of viral envelope spikes through directed evolution by Leaman, Daniel P, Zwick, Michael B

“…The functional HIV-1 envelope glycoprotein (Env) trimer, the target of anti-HIV-1 neutralizing antibodies (Abs), is innately labile and coexists with…”
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Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization by Kim, Arthur S, Leaman, Daniel P, Zwick, Michael B

“…Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with…”
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Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions by Rujas, Edurne, Leaman, Daniel P, Insausti, Sara, Ortigosa-Pascual, Lei, Zhang, Lei, Zwick, Michael B, Nieva, José L

“…The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of the envelope glycoprotein (Env)…”
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Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes by Leaman, Daniel P, Lee, Jeong Hyun, Ward, Andrew B, Zwick, Michael B

“…HIV-1 envelope glycoprotein (Env) spikes are prime vaccine candidates, at least in principle, but suffer from instability, molecular heterogeneity and a low…”
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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions by Scherer, Erin M, Leaman, Daniel P, Zwick, Michael B, McMichael, Andrew J, Burton, Dennis R

“…The broadly neutralizing anti-HIV antibody 4E10 recognizes an epitope very close to the virus membrane on the glycoprotein gp41. It was previously shown that…”
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In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1 by LEAMAN, Daniel P, KINKEAD, Heather, ZWICK, Michael B

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Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments by Rujas, Edurne, Insausti, Sara, Leaman, Daniel P., Carravilla, Pablo, González-Resines, Saul, Monceaux, Valérie, Sánchez-Eugenia, Rubén, García-Porras, Miguel, Iloro, Ibon, Zhang, Lei, Elortza, Félix, Julien, Jean-Philippe, Saéz-Cirión, Asier, Zwick, Michael B., Eggeling, Christian, Ojida, Akio, Domene, Carmen, Caaveiro, Jose M.M., Nieva, José L.

“…The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates…”
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Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules by Gach, Johannes S, Leaman, Daniel P, Zwick, Michael B

“…HIV-1 envelope glycoprotein (Env) spikes are supported at the viral membrane interface by a highly conserved and hydrophobic region of gp41, designated the…”
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A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin by Vamva, Eirini, Ozog, Stosh, Leaman, Daniel P., Yu-Hong Cheng, Rene, Irons, Nicholas J., Ott, Andee, Stoffers, Claire, Khan, Iram, Goebrecht, Geraldine K.E., Gardner, Matthew R., Farzan, Michael, Rawlings, David J., Zwick, Michael B., James, Richard G., Torbett, Bruce E.

“…Barriers to effective gene therapy for many diseases include the number of modified target cells required to achieve therapeutic outcomes and host immune…”
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Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1) by Agrawal, Nitish, Leaman, Daniel P, Rowcliffe, Eric, Kinkead, Heather, Nohria, Raman, Akagi, Junya, Bauer, Katherine, Du, Sean X, Whalen, Robert G, Burton, Dennis R, Zwick, Michael B

“…The HIV-1 envelope glycoprotein (Env) spike is challenging to study at the molecular level, due in part to its genetic variability, structural heterogeneity…”
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Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile by Rujas, Edurne, Leaman, Daniel P., Insausti, Sara, Carravilla, Pablo, García-Porras, Miguel, Largo, Eneko, Morillo, Izaskun, Sánchez-Eugenia, Rubén, Zhang, Lei, Cui, Hong, Iloro, Ibon, Elortza, Félix, Julien, Jean-Philippe, Eggeling, Christian, Zwick, Michael B., Caaveiro, Jose M.M., Nieva, José L.

“…Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit…”
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A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41 by Murray, Edward J, Leaman, Daniel P, Pawa, Nishant, Perkins, Hannah, Pickford, Chris, Perros, Manos, Zwick, Michael B, Butler, Scott L

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Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate by Narayan, Kristin M, Agrawal, Nitish, Du, Sean X, Muranaka, Janelle E, Bauer, Katherine, Leaman, Daniel P, Phung, Pham, Limoli, Kay, Chen, Helen, Boenig, Rebecca I, Wrin, Terri, Zwick, Michael B, Whalen, Robert G

“…Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to…”
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Membrane Env Liposomes Facilitate Immunization with Multivalent Full-Length HIV Spikes by Leaman, Daniel P, Stano, Armando, Chen, Yajing, Zhang, Lei, Zwick, Michael B

“…A major goal of HIV vaccine design is to elicit broadly neutralizing antibodies (bNAbs). Such bNAbs target HIV's trimeric, membrane-embedded envelope…”
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Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability by Dubrovskaya, Viktoriya, Tran, Karen, Ozorowski, Gabriel, Guenaga, Javier, Wilson, Richard, Bale, Shridhar, Cottrell, Christopher A., Turner, Hannah L., Seabright, Gemma, O’Dell, Sijy, Torres, Jonathan L., Yang, Lifei, Feng, Yu, Leaman, Daniel P., Vázquez Bernat, Néstor, Liban, Tyler, Louder, Mark, McKee, Krisha, Bailer, Robert T., Movsesyan, Arlette, Doria-Rose, Nicole A., Pancera, Marie, Karlsson Hedestam, Gunilla B., Zwick, Michael B., Crispin, Max, Mascola, John R., Ward, Andrew B., Wyatt, Richard T.

“…The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most…”
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Dense Array of Spikes on HIV-1 Virion Particles by Stano, Armando, Leaman, Daniel P, Kim, Arthur S, Zhang, Lei, Autin, Ludovic, Ingale, Jidnyasa, Gift, Syna K, Truong, Jared, Wyatt, Richard T, Olson, Arthur J, Zwick, Michael B

“…HIV-1 is rare among viruses for having a low number of envelope glycoprotein (Env) spikes per virion, i.e., ∼7 to 14. This exceptional feature has been…”
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Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex by Gift, Syna Kuriakose, Leaman, Daniel P, Zhang, Lei, Kim, Arthur S, Zwick, Michael B

“…The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer…”
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Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike by Lee, Jeong Hyun, Leaman, Daniel P., Kim, Arthur S., Torrents de la Peña, Alba, Sliepen, Kwinten, Yasmeen, Anila, Derking, Ronald, Ramos, Alejandra, de Taeye, Steven W., Ozorowski, Gabriel, Klein, Florian, Burton, Dennis R., Nussenzweig, Michel C., Poignard, Pascal, Moore, John P., Klasse, Per Johan, Sanders, Rogier W., Zwick, Michael B., Wilson, Ian A., Ward, Andrew B.

“…The recent identification of three broadly neutralizing antibodies (bnAbs) against gp120–gp41 interface epitopes has expanded the targetable surface on the…”
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An MPER antibody neutralizes HIV-1 using germline features shared among donors by Zhang, Lei, Irimia, Adriana, He, Lingling, Landais, Elise, Rantalainen, Kimmo, Leaman, Daniel P., Vollbrecht, Thomas, Stano, Armando, Sands, Daniel I., Kim, Arthur S., Poignard, Pascal, Burton, Dennis R., Murrell, Ben, Ward, Andrew B., Zhu, Jiang, Wilson, Ian A., Zwick, Michael B.

“…The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER…”
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