Search Results - "Leal Rojas, Pamela"

Quantitative phosphoproteomic analysis of IL-33-mediated signaling by Pinto, Sneha M., Nirujogi, Raja Sekhar, Rojas, Pamela Leal, Patil, Arun H., Manda, Srikanth S., Subbannayya, Yashwanth, Roa, Juan Carlos, Chatterjee, Aditi, Prasad, T. S. Keshava, Pandey, Akhilesh

“…Interleukin‐33 (IL‐33) is a novel member of the IL‐1 family of cytokines that plays diverse roles in the regulation of immune responses. IL‐33 exerts its…”
Get full text

The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target by Koorstra, Jan-Bart M., Karikari, Collins, Feldmann, Georg, Bisht, Savita, Leal-Rojas, Pamela, Offerhaus, G. Johann A., Alvarez, Hector, Maitra, Anirban

“…Pancreatic cancer is a near uniformly lethal disease and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics…”
Get full text

Toward the human cellular microRNAome by McCall, Matthew N, Kim, Min-Sik, Adil, Mohammed, Patil, Arun H, Lu, Yin, Mitchell, Christopher J, Leal-Rojas, Pamela, Xu, Jinchong, Kumar, Manoj, Dawson, Valina L, Dawson, Ted M, Baras, Alexander S, Rosenberg, Avi Z, Arking, Dan E, Burns, Kathleen H, Pandey, Akhilesh, Halushka, Marc K

“…MicroRNAs are short RNAs that serve as regulators of gene expression and are essential components of normal development as well as modulators of disease…”
Get full text

Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy by Alvarez, Hector, MD, Rojas, Pamela Leal, MD, Yong, Ken-Tye, PhD, Ding, Hong, PhD, Xu, Gaixia, PhD, Prasad, Paras N., PhD, Wang, Jean, MD, Canto, Marcia, MD, Eshleman, James R., MD, PhD, Montgomery, Elizabeth A., MD, Maitra, Anirban, MBBS

“…Abstract Esophageal adenocarcinoma arises in the backdrop of Barrett metaplasia-dysplasia sequence, with the vast majority of patients presenting with…”
Get full text

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer by Weber, Helga, Valbuena, José R, Barbhuiya, Mustafa A, Stein, Stefan, Kunkel, Hana, García, Patricia, Bizama, Carolina, Riquelme, Ismael, Espinoza, Jaime A, Kurtz, Stephen E, Tyner, Jeffrey W, Calderon, Juan Francisco, Corvalán, Alejandro H, Grez, Manuel, Pandey, Akhilesh, Leal-Rojas, Pamela, Roa, Juan C

“…Gallbladder cancer (GBC) is a lethal cancer with poor prognosis associated with high invasiveness and poor response to chemotherapy and radiotherapy. New…”
Get full text

PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40) by Subbannayya, Tejaswini, Leal-Rojas, Pamela, Zhavoronkov, Alex, Ozerov, Ivan V., Korzinkin, Mikhail, Babu, Niraj, Radhakrishnan, Aneesha, Chavan, Sandip, Raja, Remya, Pinto, Sneha M., Patil, Arun H., Barbhuiya, Mustafa A., Kumar, Prashant, Guerrero-Preston, Rafael, Navani, Sanjay, Tiwari, Pramod K., Kumar, Rekha Vijay, Prasad, T. S. Keshava, Roa, Juan Carlos, Pandey, Akhilesh, Sidransky, David, Gowda, Harsha, Izumchenko, Evgeny, Chatterjee, Aditi

“…Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late…”
Get full text

Su1999 Proteomic Analysis of Gallbladder Cancer to Identify Biomarkers and Therapeutic Targets by Barbhuiya, Mustafa A, Subbannayya, Tejaswini, Leal-Rojas, Pamela A, Shahasrabudhe, Nandini, Renuse, Santosh, Patil, Arun H, Garcia, Patricia, Navani, Sanjay, Tiwari, Pramod K, Santosh, Vani, Prasad, T.S. Keshava, Gowda, Harsha, Yadav, Thakur D, Roa, Juan C, Chatterjee, Aditi, Pandey, Akhilesh

Get full text

Clinical and public health research using methylated DNA Immunoprecipitation (MeDIP): A comparison of commercially available kits to examine differential DNA methylation across the genome by Brebi-Mieville, Priscilla, Ili-Gangas, Carmen, Leal-Rojas, Pamela, Noordhuis, Maartje G., Soudry, Ethan, Perez, Jimena, Roa, Juan Carlos, Sidransky, David, Guerrero-Preston, Rafael

“…The methylated DNA immunoprecipitation method (MeDIP) is a genome-wide, high-resolution approach that detects DNA methylation with oligonucleotide tiling…”
Get full text

CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review by Durán-Vinet, Benjamín, Araya-Castro, Karla, Calderón, Juan, Vergara, Luis, Weber, Helga, Retamales, Javier, Araya-Castro, Paulina, Leal-Rojas, Pamela

“…Colorectal cancer (CRC) is the third most prevalent cancer with the second highest mortality rate worldwide. CRC is a heterogenous disease with multiple risk…”
Get full text

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer by Subbannayya, Tejaswini, Leal-Rojas, Pamela, Barbhuiya, Mustafa A, Raja, Remya, Renuse, Santosh, Sathe, Gajanan, Pinto, Sneha M, Syed, Nazia, Nanjappa, Vishalakshi, Patil, Arun H, Garcia, Patricia, Sahasrabuddhe, Nandini A, Nair, Bipin, Guerrero-Preston, Rafael, Navani, Sanjay, Tiwari, Pramod K, Santosh, Vani, Sidransky, David, Prasad, T S Keshava, Gowda, Harsha, Roa, Juan Carlos, Pandey, Akhilesh, Chatterjee, Aditi

“…Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted…”
Get full text

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways by Wu, Xinyan, Zahari, Muhammad Saddiq, Ma, Binyun, Liu, Ren, Renuse, Santosh, Sahasrabuddhe, Nandini A, Chen, Lily, Chaerkady, Raghothama, Kim, Min-Sik, Zhong, Jun, Jelinek, Christine, Barbhuiya, Mustafa A, Leal-Rojas, Pamela, Yang, Yi, Kashyap, Manoj Kumar, Marimuthu, Arivusudar, Ling, Min, Fackler, Mary Jo, Merino, Vanessa, Zhang, Zhen, Zahnow, Cynthia A, Gabrielson, Edward, Stearns, Vered, Roa, Juan Carlos, Sukumar, Saraswati, Gill, Parkash S, Pandey, Akhilesh

“…Breast cancer is the most prevalent cancer in women worldwide. About 15-20% of all breast cancers are triple negative breast cancer (TNBC) and are often highly…”
Get full text

Abstract 4899: Identification of epigenomics biomarkers for early detection and progression of cervical carcinogenesis by Brebi, Priscilla, Ili-Gangas, Carmen, Leal-Rojas, Pamela, García, Patricia, Ostrow, Kimberly, Perez, Jimena, Guerrero-Preston, Rafael, Soudry, Ethan, Roa, Juan C., Sidransky, David

“…Introduction: Pap smears and HPV infection tests have been the most widely used tools to detect cytological abnormalities and women's risk of developing…”
Get full text

Promoter hypermethylation gene patterns in gynecological tumors by Leal Rojas, Pamela, Anabalón Rodríguez, Leonardo, García Muñoz, Patricia, Tapia Escalona, Oscar, Guzmán González, Pablo, Araya Orostica, Juan Carlos, Villaseca Hernández, Miguel, Roa Strauch, Juan Carlos

“…Gene silencing mediated by the aberrant methylation of the promoter region of DNA is involved in the inactivation of genes implicated in various metabolic…”
Get more information