Search Results - "Leal, Vinicius N. C."

Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 by de Souza Andrade, Milena M, Leal, Vinicius N. C, Fernandes, Iara G, Gozzi-Silva, Sarah C, Beserra, Danielle R, Oliveira, Emily A, Teixeira, Franciane M. E, Yendo, Tatiana M, Sousa, Maria da Glória T, Teodoro, Walcy R, Oliveira, Luana de M, Alberca, Ricardo W, Aoki, Valéria, Duarte, Alberto J. S, Sato, Maria N

“…The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, supplements…”
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Inflammasome genetics and complex diseases: a comprehensive review by Fernandes, Fernanda Pereira, Leal, Vinicius N C, Souza de Lima, Dhemerson, Reis, Edione C, Pontillo, Alessandra

“…The inflammasome is a cytoplasmic multiprotein complex responsible for the activation of inflammatory caspases (caspase-1, -4, and -5) in response to pathogen-…”
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A common variant close to the “tripwire” linker region of NLRP1 contributes to severe COVID-19 by Leal, Vinicius N. C., Paulino, Leandro M., Cambui, Raylane A. G., Zupelli, Thiago G., Yamada, Suemy M., Oliveira, Leonardo A. T., Dutra, Valéria de F., Bub, Carolina B., Sakashita, Araci M., Yokoyama, Ana Paula H., Kutner, José M., Vieira, Camila A., Santiago, Wellyngton M. de S., Andrade, Milena M. S., Teixeira, Franciane M. E., Alberca, Ricardo W., Gozzi-Silva, Sarah C., Yendo, Tatiana M., Netto, Lucas C., Duarte, Alberto J. S., Sato, Maria N., Venturini, James, Pontillo, Alessandra

“…Objective and design The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of…”
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Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas by Souza De Lima, Dhêmerson, Bomfim, Caio C B, Leal, Vinícius N C, Reis, Edione C, Soares, Jaíne L S, Fernandes, Fernanda P, Amaral, Eduardo P, Loures, Flavio V, Ogusku, Mauricio M, Lima, Maria R D'Imperio, Sadahiro, Aya, Pontillo, Alessandra

“…The interplay between (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still…”
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Unexplained fever with consumptive syndrome in the elderly: two cases of VEXAS syndrome with inflammasome dysregulation by Mendonça, Leonardo Oliveira, Leal, Vinicius N C, Roa, Mariela E G V, Barros, Samar Freschi, Kalil, Jorge, Pontillo, Alessandra

“…The aim of this study is to investigate the inflammasome dysregulation in peripheral blood leukocytes of VEXAS patients. The constitutive and in vitro…”
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Severe COVID‐19 patients show a dysregulation of the NLRP3 inflammasome in circulating neutrophils by Leal, Vinicius N. C., Andrade, Milena M. S., Teixeira, Franciane M. E., Cambui, Raylane A. G., Roa, Mariela E. G. V., Marra, Letícia G., Yamada, Suemy M., Alberca, Ricardo W., Gozzi‐Silva, Sarah C., Yendo, Tatiana M., Netto, Lucas C., Duarte, Alberto J. S., Sato, Maria N., Pontillo, Alessandra

“…SARS‐CoV‐2 triggers inflammasome‐dependent release of pro‐inflammatory cytokine IL‐1β and pyroptosis, therefore, contributes to the huge inflammatory response…”
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Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis? by de Moraes Rodrigues, Juliana, Souza de Lima, Dhemerson, Leal, Vinicius N. C., Bosco, Adriana A., Sandrim, Valeria, Pontillo, Alessandra

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Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes by Reis, Aramys S, Barboza, Renato, Murillo, Oscar, Barateiro, André, Peixoto, Erika P M, Lima, Flávia A, Gomes, Vinícius M, Dombrowski, Jamille G, Leal, Vinícius N C, Araujo, Franciele, Bandeira, Carla L, Araujo, Rosana B D, Neres, Rita, Souza, Rodrigo M, Costa, Fabio T M, Pontillo, Alessandra, Bevilacqua, Estela, Wrenger, Carsten, Wunderlich, Gerhard, Palmisano, Giuseppe, Labriola, Leticia, Bortoluci, Karina R, Penha-Gonçalves, Carlos, Gonçalves, Lígia A, Epiphanio, Sabrina, Marinho, Claudio R F

“…Placental malaria (PM) is associated with severe inflammation leading to abortion, preterm delivery, and intrauterine growth restriction. Innate immunity…”
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BTK and MMP9 regulate NLRP3 inflammasome-dependent cytokine and NET responses in primary neutrophils by Leal, Vinicius N.C., Bork, Francesca, Tortola, Maria Mateo, Guilleaume, Juli-Christin von, Greve, Carsten L., Bugl, Stefanie, Danker, Bettina, Grimbacher, Bodo, Pontillo, Alessandra, Weber, Alexander N.R.

“…[Display omitted] Inflammation is a double-edged state of immune activation required to resolve threats harmful to the host but can also cause severe…”
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naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation by Bork, Francesca, Greve, Carsten L, Youn, Christine, Chen, Sirui, N C Leal, Vinicius, Wang, Yu, Fischer, Berenice, Nasri, Masoud, Focken, Jule, Scheurer, Jasmin, Engels, Pujan, Dubbelaar, Marissa, Hipp, Katharina, Zalat, Baher, Szolek, Andras, Wu, Meng-Jen, Schittek, Birgit, Bugl, Stefanie, Kufer, Thomas A, Löffler, Markus W, Chamaillard, Mathias, Skokowa, Julia, Kramer, Daniela, Archer, Nathan K, Weber, Alexander N R

“…Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs). NETs…”
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Antagonistic role of IL-1ß and NLRP3/IL-18 genetics in chronic HIV-1 infection by Reis, Edione C., Leal, Vinicius N.C., da Silva, Lais T., dos Reis, Marilia M.L., Argañaraz, Enrique R., Oshiro, Telma M., Pontillo, Alessandra

“…Host genetics affects both susceptibility and progression of HIV-1 infection. NLRP3 inflammasome provides a first-line defense in viral infections, and,…”
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