Search Results - "Leal, Paulo César"

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation by da Costa, Diogo Santos M., Meotti, Flavia Carla, Andrade, Edinéia Lemos, Leal, Paulo César, Motta, Emerson Marcelo, Calixto, João B.

“…This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete…”
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The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice by Bento, Allisson Freire, Leite, Daniela Ferraz Pereira, Claudino, Rafaela Franco, Hara, Daniela Balz, Leal, Paulo César, Calixto, João B.

“…Although neutrophils are strongly implicated in eliminating pathogens, excessive recruitment may cause tissue damage. Therefore, reducing cell influx during an…”
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Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation by Mielcke, Tânia R., Mascarello, Alessandra, Filippi-Chiela, Eduardo, Zanin, Rafael F., Lenz, Guido, Leal, Paulo César, Chirardia, Louise D., Yunes, Rosendo A., Nunes, Ricardo J., Battastini, Ana M.O., Morrone, Fernanda B., Campos, Maria M.

“…Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds…”
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Pharmacokinetics and tissue distribution of the sesquiterpene alpha-humulene in mice by Chaves, Juliana Siqueira, Leal, Paulo César, Pianowisky, Luis, Calixto, João B

“…A quantitative study was undertaken to assess the plasma and tissue levels, tissue distribution and skin (ear) absorption of the sesquiterpene alpha-humulene,…”
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Antiherpetic mechanism of a sulfated derivative of Agaricus brasiliensis fruiting bodies polysaccharide by Cardozo, Francielle Tramontini Gomes de Sousa, Camelini, Carla Maísa, Leal, Paulo César, Kratz, Jadel Müller, Nunes, Ricardo José, Mendonça, Margarida Matos de, Simões, Cláudia Maria Oliveira

“…To study the anti-herpes simplex virus (HSV) activity of a (1→6)-(1→3)-β-D-glucan isolated from Agaricus brasiliensis fruiting bodies (FR) as well as its…”
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In vitro and in vivo anti-glioma activity of a chalcone-quinoxaline hybrid by Loch-Neckel, Gecioni, Bicca, Maíra Assunção, Leal, Paulo César, Mascarello, Alessandra, Siqueira, Jarbas Mota, Calixto, João B.

“…Chalcones are important compounds that exhibit multiple biological activities, including anti-inflammatory, antimitotic and antibacterial properties. In the…”
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Evaluation of Anti-HSV-2 Activity of Gallic Acid and Pentyl Gallate by Kratz, Jadel Müller, Andrighetti-Fröhner, Carla Regina, Leal, Paulo César, Nunes, Ricardo José, Yunes, Rosendo Augusto, Trybala, Edward, Bergström, Tomas, Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira

“…The synthetic n-alkyl esters of gallic acid, also known as gallates, are widely employed as antioxidants by food and pharmaceutical industries. Besides the…”
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Synthetic organic compounds with potential for bacterial biofilm inhibition, a path for the identification of compounds interfering with quorum sensing by de Lima Pimenta, Andréa, Chiaradia-Delatorre, Louise Domeneghini, Mascarello, Alessandra, de Oliveira, Karen Andrinéia, Leal, Paulo César, Yunes, Rosendo Augusto, de Aguiar, Cláudia Beatriz Nedel Mendes, Tasca, Carla Inês, Nunes, Ricado José, Smânia, Artur

“…Abstract New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or…”
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TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury by Andrade, Edinéia Lemos, Forner, Stefânia, Bento, Allisson Freire, Leite, Daniela Ferraz Pereira, Dias, Marcos Antonio, Leal, Paulo César, Koepp, Janice, Calixto, João B

“…The ankyrin-repeat transient receptor potential 1 (TRPA1) has been implicated in pathological conditions of the bladder, but its role in overactive bladder…”
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Synthesis of chalcone analogues with increased antileishmanial activity by Boeck, Paula, Bandeira Falcão, Camila Alves, Leal, Paulo César, Yunes, Rosendo Augusto, Filho, Valdir Cechinel, Torres-Santos, Eduardo Caio, Rossi-Bergmann, Bartira

“…Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective…”
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PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia by Silveira, André Bortolini, Laranjeira, Angelo Brunelli Albertoni, Rodrigues, Gisele Olinto Libanio, Leal, Paulo César, Caetano Cardoso, Bruno António, Barata, João, Yunes, Rosendo Augusto, Zanchin, Nilson Ivo Tonin, Brandalise, Sílvia Regina, Yunes, José Andrés

“…© Impact Journals, LLC. The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K…”
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Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum by Bertoldo, Jean Borges, Chiaradia-Delatorre, Louise Domeneghini, Mascarello, Alessandra, Leal, Paulo César, Cordeiro, Marlon Norberto Sechini, Nunes, Ricardo José, Sarduy, Emir Salas, Rosenthal, Philip Jon, Terenzi, Hernán

“…Falcipain-2 (FP-2) is a key cysteine protease from the malaria parasite Plasmodium falciparum. Many previous studies have identified FP-2 inhibitors; however,…”
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Investigating the generation of wood wastes from mechanical processing of two forest species by Silva, Carlos Eduardo Silveira da, Xavier, Carolina Nogueira, Junqueira, Amanda Arantes, Neves Junior, Osmar de Freitas, Carvalho, Paulo César Leal de, Torres, Adriana Cazelgrandi, Carvalho, Alexandre Monteiro de

“…The circular saw is a tool commonly used for wood processing. It may be presented at different models. Considering their specificities, they can generate…”
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Inhibition of phosphatidylinositol-3 kinase γ reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice by Pereira, Paula Juliana Seadi, Lazarotto, Lais Fernanda, Leal, Paulo César, Lopes, Tiago Giuliani, Morrone, Fernanda Bueno, Campos, Maria Martha

“…It is suggested that phosphatidylinositol-3 kinase γ activation represents a relevant signaling pathway implicated in the pruriceptive, inflammatory, and…”
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Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate by Kratz, Jadel Müller, Andrighetti-Fröhner, Carla Regina, Kolling, Deise Juliana, Leal, Paulo César, Cirne-Santos, Cláudio César, Yunes, Rosendo Augusto, Nunes, Ricardo José, Trybala, Edward, Bergström, Tomas, Frugulhetti, Izabel CPP, Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira

“…The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by…”
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Comparison between Resistograph Analysis with Physical Properties of the Wood of Brazilian Native Tree Species by Silva, Carlos Eduardo Silveira da, Pace, José Henrique Camargo, Gomes, Fernando José Borges, Carvalho, Paulo César Leal de, Reis, Claudia de Azevedo, Latorraca, João Vicente de Figueiredo, Rolim, Samir Gonçalves, Carvalho, Alexandre Monteiro de

“…ABSTRACT There is just little information about the technological aspects of the wood of Brazilian native tree species, which limits their suitable use. The…”
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Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure–activity relationships by Chiaradia, Louise Domeneghini, dos Santos, Rodrigo, Vitor, Carlos Eduardo, Vieira, André Alexandre, Leal, Paulo César, Nunes, Ricardo José, Calixto, João Batista, Yunes, Rosendo Augusto

“…Between 14 chalcones chemically derived from 2,4,6-trimethoxyacetophenone (five of them showed for the first time), eight inhibited the nitrite production in…”
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Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position by Winter, Evelyn, Gozzi, Gustavo Jabor, Chiaradia-Delatorre, Louise Domeneghini, Daflon-Yunes, Nathalia, Terreux, Raphael, Gauthier, Charlotte, Mascarello, Alessandra, Leal, Paulo César, Cadena, Silvia M, Yunes, Rosendo Augusto, Nunes, Ricardo José, Creczynski-Pasa, Tania Beatriz, Di Pietro, Attilio

“…A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors of breast cancer resistance protein-mediated…”
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Influence of chalcone analogues on serum glucose levels in hyperglycemic rats by Alberton, Elga Heloísa, Damazio, Rosangela Guollo, Cazarolli, Luisa Helena, Chiaradia, Louise Domeneghini, Leal, Paulo César, Nunes, Ricardo José, Yunes, Rosendo Augusto, Silva, Fátima Regina Mena Barreto

“…A series of chalcone derivatives from 3,4-methylenedioxybenzaldehyde and substituted acetophenones have been synthesized and investigated as antihyperglycemic…”
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Acylhydrazones contribute to serum glucose homeostasis through dual physiological targets by Frederico, Marisa Jádna Silva, Castro, Allisson Jhonatan Gomes, Mascarello, Alessandra, Mendes, Camila Pires, Kappel, Virgínia Dermachi, Stumpf, Taisa Regina, Leal, Paulo Cesar, Nunes, Ricardo José, Yunes, Rosendo Augusto, Silva, Fátima Regina Mena Barreto

“…In this study the in vivo and in vitro antidiabetic effects of four acylhydrazone derivatives were investigated in rats. The secretagogue action, oral glucose…”
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